In-Line Reactions and Ionizations of Vaporized Diphenylchloroarsine and Diphenylcyanoarsine in Atmospheric Pressure Chemical Ionization Mass Spectrometry

Abstract

MS 3 analysisChemical warfare agents Abstract. We propose detecting a fragment ion (Ph 2 As + ) using counter-flow introduction atmospheric pressure chemical ionization ion trap mass spectrometry for sensitive air monitoring of chemical warfare vomiting agents diphenylchloroarsine (DA) and diphenylcyanoarsine (DC). The liquid sample containing of DA, DC, and bis(diphenylarsine)oxide (BDPAO) was heated in a dry air line, and the generated vapor was mixed into the humidified air flowing through the sampling line of a mass spectrometer. Humidity effect on the air monitoring was investigated by varying the humidity of the analyzed air sample. Evidence of the in-line conversion of DA and DC to diphenylarsine hydroxide (DPAH) and then BDPAO was obtained by comparing the chronograms of various ions from the beginning of heating. Multiple-stage mass spectrometry revealed that the protonated molecule (MH + ) of DA, DC, DPAH, and BDPAO could produce Ph 2 As + through their in-source fragmentation. Among the signals of the ions that were investigated, the Ph 2 As + signal was the most intense and increased to reach a plateau with the increased air humidity, whereas the MH + signal of DA decreased. It was suggested that DA and DC were converted in-line into BDPAO, which was a major source of Ph 2 As + .

Identification of V‐type nerve agents in vapor samples using a field‐portable capillary gas chromatography/membrane‐interfaced electron ionization quadrupole mass spectrometry instrument with Tri‐Bed concentrator and fluoridating conversion tube

“…We have previously evaluated the performance of commercially available on‐site detection equipment, including handheld gas detection tubes, ion mobility spectrometry (IMS) instruments, an arrayed surface acoustic wave sensor and a Raman spectrometer . Moreover, we have developed new field‐deployable detection equipment, such as an amperometric sensor, an atmospheric pressure counter‐flow chemical ionization ion trap mass spectrometry (MS) instrument, an electron cyclotron resonance ion source MS instrument and a low‐temperature plasma ionization MS instrument . Within field‐deployable technologies, gas chromatography (GC)–MS instruments are the most promising candidates .…”

Direct Analysis of Carbonyl Compounds by Mass Spectrometry with Double-Region Atmospheric Pressure Chemical Ionization

“…APCI, using corona discharge at atmospheric pressure, represents a soft-ionization method where molecular ions play the dominant role in mass spectrum. APCI-MS is therefore conveniently applied in gas sample analysis and has been used in a number of areas including exhalation in medical application, food flavor classification, − VOC and biogenic VOC detection, − and chemical warfare agent monitoring. − Meanwhile, APCI has been modified to improve ionization efficiency and simplify analytical procedures. Le Quere et al developed an APCI source with low dead volume for online analyses of aroma compounds .…”

“…Usmanov et al developed a new analytical method for detection of explosives through an alternating current corona discharge APCI source which was more robust than that of the direct current corona . Seto et al developed a counter-flow introduction (CFI) APCI source for the detection of chemical warfare agents in air. − The LODs of the chemical warfare agents were within 1 to 8 μg·m –3 with significantly improved instrument performance. Unfortunately, CFI-APCI combined with ion trap mass spectrometry has received in widespread use.…”