2016
DOI: 10.1096/fj.201601083r
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In neonates S100A8/S100A9 alarmins prevent the expansion of a specific inflammatory monocyte population promoting septic shock

Abstract: The high susceptibility of newborn infants to sepsis is ascribed to an immaturity of the neonatal immune system, but the molecular mechanisms remain unclear. Newborn monocytes massively release the alarmins S100A8/S100A9. In adults, these are major regulators of immunosuppressive myeloid-derived suppressor cells (MDSCs). We investigated whether S100A8/S100A9 cause an expansion of monocytic MDSCs (Mo-MDSCs) in neonates, thereby contributing to an immunocompromised state. Mo-MDSCs have been assigned to CD14/huma… Show more

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Cited by 39 publications
(50 citation statements)
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“…Two characteristics of newborn infants (i.e., the significant physiologic leukocyte trafficking taking place after birth) (7)(8)(9)(10)(11)(12)(13)(14)(15) and the high susceptibility to SIRS upon inflammatory challenges (3)(4)(5)(6), point to an important role of the vascular endothelium during the neonatal period. In this study, we investigated the biology of the endothelium in neonates in health and disease.…”
Section: Discussionmentioning
confidence: 99%
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“…Two characteristics of newborn infants (i.e., the significant physiologic leukocyte trafficking taking place after birth) (7)(8)(9)(10)(11)(12)(13)(14)(15) and the high susceptibility to SIRS upon inflammatory challenges (3)(4)(5)(6), point to an important role of the vascular endothelium during the neonatal period. In this study, we investigated the biology of the endothelium in neonates in health and disease.…”
Section: Discussionmentioning
confidence: 99%
“…The neonatal period is a specific transition phase in life with profound immunologic changes at the cellular and molecular levels that come along with a high vulnerability of newborn infants to inflammatory diseases (1)(2)(3)(4)(5)(6). After birth, a considerable shift of leukocytes in organs and at interfaces takes place (7)(8)(9)(10)(11)(12)(13)(14)(15).…”
mentioning
confidence: 99%
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“…S100A8 is a calcium-and zinc-binding protein, with S100A8/A9 subunits forming calprotectin. S100A8 regulates inflammatory and immune processes, and can ameliorate tissue damage caused by reactive oxygen species [17]. In neonates S100A8/S100A9 alarmins prevent the expansion of inflammatory monocytes promoting septic shock [17].…”
Section: Proteins Altered In Csfmentioning
confidence: 99%
“…S100A8 regulates inflammatory and immune processes, and can ameliorate tissue damage caused by reactive oxygen species [17]. In neonates S100A8/S100A9 alarmins prevent the expansion of inflammatory monocytes promoting septic shock [17]. S100A8 is a plausible biomarker for HI based on its well-known regulation by ischemia, the prominent rise in CSF levels and early activation.…”
Section: Proteins Altered In Csfmentioning
confidence: 99%