In-office thermal systems for the treatment of dry eye disease

Beining, MW; Magno, Morten Schjerven; Moschowits, Emily; Olafsson, Jonatan; Vehof, Jelle; Dartt, Darlene A.; Utheim, T.P.

doi:10.1016/j.survophthal.2022.02.007

Cited by 16 publications

(17 citation statements)

References 37 publications

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“…The instrument allows viewing of gland orifices and customization of pressure during heating and compression phases. 13 , 18 …”

Section: Methodsmentioning

confidence: 99%

“… 11 , 12 Thus, the treatment of MGD generally focuses on application of external heat and pressure, which helps in melting meibum and increasing secretion. 13 Although self-treatments such as warm compress and eyelid massage are the first steps in MGD treatment, patient compliance is generally low and some patients may not achieve long-lasting improvement in symptoms. 13 In such cases, in-office eyelid heating therapy, such as thermal pulsation systems, are a good alternative.…”

Section: Introductionmentioning

confidence: 99%

“… 13 Although self-treatments such as warm compress and eyelid massage are the first steps in MGD treatment, patient compliance is generally low and some patients may not achieve long-lasting improvement in symptoms. 13 In such cases, in-office eyelid heating therapy, such as thermal pulsation systems, are a good alternative. 13 These devices apply heat at appropriate temperature and compress the meibomian glands simultaneously, to facilitate the release of contents into the tear film.…”

Section: Introductionmentioning

confidence: 99%

“… 13 In such cases, in-office eyelid heating therapy, such as thermal pulsation systems, are a good alternative. 13 These devices apply heat at appropriate temperature and compress the meibomian glands simultaneously, to facilitate the release of contents into the tear film. 14 Thermal pulsation therapies, such as LipiFlow and Systane iLux, have been reported to be highly efficient, with the effects lasting for up to 12 months.…”

Section: Introductionmentioning

confidence: 99%

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Systane iLux Thermal Pulsation System in the Treatment of Meibomian Gland Dysfunction: A Post-Hoc Analysis of a 12-Month, Randomized, Multicenter Study

Wesley¹,

Bickle²,

Downing³

et al. 2022

OPTH

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This study aimed to demonstrate the effectiveness of Systane iLux, a thermal pulsation device, in patients with MGD, over 12 months post-single treatment. Methods: This is a post-hoc analysis of a previous prospective, assessor-masked, parallel-group, multicenter study (NCT03956225) that compared the effectiveness and safety of iLux with LipiFlow in subjects with MGD. The original study included subjects with meibomian gland score (MGS) ≤12 in lower eyelids, Impact of Dry Eye on Everyday Life-Symptom Bother (IDEEL-SB) module score >16, and non-invasive tear break-up time (NITBUT) <10 seconds. Subjects were randomized (1:1) to receive a single bilateral treatment of iLux or LipiFlow. In this post-hoc analysis, mean changes in MGS, NITBUT (first break-up; seconds), IDEEL-SB module score, and corneal staining, from baseline to 12 months were analyzed post-single treatment with iLux. Results: Data from 119 patients (n=238 eyes) treated with iLux were analyzed. The mean±SD age of the subjects was 58.4±13.4 years, with majority being female (79.0%). MGS (mean±SD) for both eyes improved significantly from baseline to 12 months (OD [baseline:

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“…The instrument allows viewing of gland orifices and customization of pressure during heating and compression phases. 13 , 18 …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Systane iLux Thermal Pulsation System in the Treatment of Meibomian Gland Dysfunction: A Post-Hoc Analysis of a 12-Month, Randomized, Multicenter Study

Wesley¹,

Bickle²,

Downing³

et al. 2022

OPTH

View full text Add to dashboard Cite

show abstract

“…However, the exact effects need to be further studied and evaluated. The chronic condition of MGD has led to the rise of many in-office treatments, which can be implemented by ophthalmologists and optometrists in different parts of the world [ 83 , 91 ].…”

Section: Prospective Future Research and Therapeutic Strategiesmentioning

confidence: 99%

Ductal Hyperkeratinization and Acinar Renewal Abnormality: New Concepts on Pathogenesis of Meibomian Gland Dysfunction

Peng

Liu

et al. 2023

CIMB

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Meibomian gland dysfunction (MGD) is a functional and morphological disorder of the meibomian glands which results in qualitative or quantitative alteration in meibum secretion and is the major cause of evaporative dry eye (EDE). EDE is often characterized by tear film instability, increased evaporation, hyperosmolarity, inflammation, and ocular surface disorder. The precise pathogenesis of MGD remains elusive. It has been widely considered that MGD develops as a result of ductal epithelial hyperkeratinization, which obstructs the meibomian orifice, halts meibum secretion, and causes secondary acinar atrophy and gland dropout. Abnormal self-renewal and differentiation of the acinar cells also play a significant role in MGD. This review summarizes the latest research findings regarding the possible pathogenesis of MGD and provides further treatment strategies for MGD-EDE patients.

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Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Kulbay,

Wu,

Truong

et al. 2024

Smart Molecules

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This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning with the foundational definition, properties, and classification of hydrogels, the review explores their synthesis and responsive capabilities. Specific applications examined encompass topical drug delivery, contact lenses, intravitreal drug delivery, ocular adhesives, vitreous substitutes, and cell‐based therapy. A methodical analysis, including an overview of relevant ocular structures and a comparative evaluation of hydrogel‐based solutions against traditional treatments, is conducted. Additionally, potential constraints, translation challenges, knowledge gaps, and research areas are identified. Our methodical approach, guided by an extensive literature review from 2017 to 2023, illuminates the unprecedented opportunities offered by hydrogels, along with pinpointing areas for further inquiry to facilitate their transition into clinical practice.

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In-office thermal systems for the treatment of dry eye disease

Cited by 16 publications

References 37 publications

Systane iLux Thermal Pulsation System in the Treatment of Meibomian Gland Dysfunction: A Post-Hoc Analysis of a 12-Month, Randomized, Multicenter Study

Systane iLux Thermal Pulsation System in the Treatment of Meibomian Gland Dysfunction: A Post-Hoc Analysis of a 12-Month, Randomized, Multicenter Study

Ductal Hyperkeratinization and Acinar Renewal Abnormality: New Concepts on Pathogenesis of Meibomian Gland Dysfunction

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

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