In-ovo monochromatic green light photostimulation enhances embryonic somatotropic axis activity

Dishon, L.; Avital-Cohen, N.; Malamud, Daniel; Heiblum, R.; Druyan, S.; Porter, Tom E.; Gumułka, Małgorzata; Rozenboim, Israel

doi:10.3382/ps/pew489

Cited by 25 publications

(20 citation statements)

References 25 publications

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“…Previous studies have demonstrated that the monochromatic green light promotes the pineal gland releasing MEL [27] and improving hepatic IGF-I synthesis and secretion, which finally accelerated the broiler growth rate [3,4,6,28]. The increased IGF-I promoted satellite-cell proliferation and differentiation [6,9], which was responsible for muscle growth [29]. In this study, GL elevated plasma MEL secretion, and this was also accompanied by increases of Mel1c and IGF-I mRNA levels in the liver.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have focused on the role of light spectra in chicken growth in recent years, finding that different wavelengths of light affected the growth of turkeys [1] and broilers [2,3]. Furthermore, green light (GL) stimulation has been shown to accelerate muscle growth in broilers [4], and enhance the secretion of insulin-like growth factor I (IGF-I) by chick embryo hepatocytes [5,6]. IGF-I has been shown to be a key regulator of muscle development and metabolism in birds and other vertebrate species [7,8], and promoted satellite cells proliferation through IGF-I signaling [9].…”

Section: Introductionmentioning

confidence: 99%

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Mel1c Mediated Monochromatic Light-Stimulated IGF-I Synthesis through the Intracellular Gαq/PKC/ERK Signaling Pathway

Ning

Wang

Cao

et al. 2019

IJMS

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Previous studies have demonstrated that monochromatic light affects plasma melatonin (MEL) levels, which in turn regulates hepatic insulin-like growth factor I (IGF-I) secretion via the Mel1c receptor. However, the intracellular signaling pathway initiated by Mel1c remains unclear. In this study, newly hatched broilers, including intact, sham operation, and pinealectomy groups, were exposed to either white (WL), red (RL), green (GL), or blue (BL) light for 14 days. Experiments in vivo showed that GL significantly promoted plasma MEL formation, which was accompanied by an increase in the MEL receptor, Mel1c, as well as phosphorylated extracellular regulated protein kinases (p-ERK1/2), and IGF-I expression in the liver, compared to the other light-treated groups. In contrast, this GL stimulation was attenuated by pinealectomy. Exogenous MEL elevated the hepatocellular IGF-I level, which is consistent with increases in cyclic adenosine monophosphate (cAMP), Gαq, phosphorylated protein kinase C (p-PKC), and p-ERK1/2 expression. However, the Mel1c selective antagonist prazosin suppressed the MEL-induced expression of IGF-I, Gαq, p-PKC, and p-ERK1/2, while the cAMP concentration was barely affected. In addition, pretreatment with Ym254890 (a Gαq inhibitor), Go9863 (a PKC inhibitor), and PD98059 (an ERK1/2 inhibitor) markedly attenuated MEL-stimulated IGF-I expression and p-ERK1/2 activity. These results indicate that Mel1c mediates monochromatic GL-stimulated IGF-I synthesis through intracellular Gαq/PKC/ERK signaling.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mel1c Mediated Monochromatic Light-Stimulated IGF-I Synthesis through the Intracellular Gαq/PKC/ERK Signaling Pathway

Ning

Wang

Cao

et al. 2019

IJMS

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“…Liang [44] showed an increase in GHRH expression from 16 days of incubation until 1-day post-hatching. GL photostimulation from ED15 increased hypothalamic GHRH mRNA expression to that of the positive control [5,45]. Accordingly, this may explain the increase in brain weight, neurons, and BI observed in the groups exposed to light compared with the control group.…”

Section: Discussionmentioning

confidence: 85%

“…Several studies demonstrated that exposing fertile eggs to light can increase the growth of the embryo and decrease the incubation period [2][3][4]. Post-hatch artificial lighting is an important management method for the growth and muscle development of meat-type birds [5]. Embryo exposure to light leads to changes in metabolic rate [6], such as an increase in embryo metabolic rate in the pigeon Columba livia in light compared with darkness [7].…”

Section: Introductionmentioning

confidence: 99%

Effect of exposure to different light colors on embryonic development and neurophysiological traits in the chick embryo

et al. 2021

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Background and Aim: Many environmental factors exist that influence embryonic development which is missing in the poultry industry, such as light in incubation facilities or hatcheries. Light plays an important role in the growth and development of chick embryos, whereas dark environments can lead to hatching failure or embryo distortion. Therefore, this study aimed to demonstrate the importance of light and its various colors on the growth and development of broiler chick embryos. Materials and Methods: Four treatments were used to study the impact of various light colors on the growth of embryos and their neurophysiological traits: Dark without light (D), red light (RL), blue light (BL), and green light (GL), with three replicates per treatment (25 eggs/replicate) for a total of 300 fertile Ross 308 eggs. Each treatment was assigned to one incubator (75 eggs/incubator), whereas all other conditions were kept the same. Results: The results showed a significant increase (p<0.01) in embryonic development for embryo weight, chick body weight, hatchability, and embryo index for RL, BL, and especially GL. RL, BL, and especially GL significantly increased (p<0.01) neurophysiological traits of the neurons, brain weight, and brain index. Conclusion: The use of light during the embryonic period affects the development of the embryo and its neurophysiological traits.

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“…It was shown in several studies, including our previous papers, that in ovo GL photostimulation elevate the expression and secretion of different components of the somatotropic axis ( Halevy et al., 1998 ; Zhang et al., 2014a , 2014b ; Dishon et al., 2017 ; Dishon et al., 2018 ). In our previous paper ( Dishon et al., 2021 ), we discovered that in ovo GL photostimulation of broiler embryos from embryonic day ( ED ) 18 until hatching (hatching period), showed similar elevation in somatotropic axis activity, manifested by increased plasma GH levels and hypothalamic GHRH and liver GHR and IGF-1 mRNA levels on the day of hatching.…”

Section: Introductionmentioning

confidence: 88%

The effect of selected in ovo green light photostimulation periods on post-hatch broiler growth and somatotropic axis activity

et al. 2021

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Targeted in ovo green light ( GL ) photostimulation during the last days of broiler egg incubation increases embryonic expression of the somatotropic axis, similar to in ovo green light photostimulation from embryonic day ( ED ) 0 to the end of incubation. The aim of this study was to examine the effect of selected in ovo GL photostimulation periods on post-hatch broiler growth. Four hundred twenty fertile broiler eggs were divided into 7 treatment groups: the first incubated in the dark (standard conditions) as a negative control; the second incubated under monochromatic GL from ED0-ED20 (positive control); the third group incubated under monochromatic GL light from ED15-ED20; the fourth, fifth and sixth groups were incubated under monochromatic GL on ED16, ED17, and ED18, respectively; and the seventh group was incubated under monochromatic GL from ED18-ED20. All illumination was provided intermittently using LED lamps. After hatch, all chicks were transferred to a controlled room under standard rearing conditions. The group incubated under green light from ED18 until hatch showed similar results to the positive control group in body weights, as well as breast muscle weights (as % of body weights), and an elevation in the somatotropic axis activity during the experiment. We suggest that broiler embryos can be exposed to in ovo GL photostimulation from ED18 until hatch (hatching period), and still exhibit the same performance as obtained by photostimulation from d 0 of incubation.

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In-ovo monochromatic green light photostimulation enhances embryonic somatotropic axis activity

Cited by 25 publications

References 25 publications

Mel1c Mediated Monochromatic Light-Stimulated IGF-I Synthesis through the Intracellular Gαq/PKC/ERK Signaling Pathway

Mel1c Mediated Monochromatic Light-Stimulated IGF-I Synthesis through the Intracellular Gαq/PKC/ERK Signaling Pathway

Effect of exposure to different light colors on embryonic development and neurophysiological traits in the chick embryo

The effect of selected in ovo green light photostimulation periods on post-hatch broiler growth and somatotropic axis activity

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