In patients with non-neuropathic cancer-related pain, does gabapentin provide additional palliative pain control as an adjunct to opioid therapy?

Abstract

In nonspecific cancer-related pain, gabapentin as an adjunct to opioid therapy leads to moderately lower opioid doses with similar pain relief (SOR B; randomized controlled trial and cohort study). In cancerrelated bone pain, gabapentin added to opioids is associated with a decrease in pain at rest and with movement (SOR C; case series).