In people who drink more, facets of theory of mind may be impaired by alcohol stimuli

Monk, Rebecca; Qureshi, Adam; Knibb, Graeme; McGale, Lauren; Nair, Leonie; Kelly, Jordan; Collins, Hope; Heim, Derek

doi:10.1016/j.drugalcdep.2023.109811

Cited by 1 publication

(1 citation statement)

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“…However, excessive drinking can lead to alcoholism, causing headaches, dizziness, vomiting, and other uncomfortable symptoms. Long-term drinking can also cause damage to the central nervous system and digestive system, leading to fatty liver, cirrhosis, and other diseases [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Structural Identification, and Screening of Egg-Derived Peptides with Facilitating Alcohol Metabolism Activity

Tan,

Wang,

Wan

et al. 2024

Foods

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The aim of this study was to obtain egg-derived peptides with facilitating alcohol metabolism (EPs) by enzymolysis, to identify their structures, and screen small polypeptides with higher activity by molecular docking. The optimum conditions for preparing EPs with facilitating alcohol metabolism were obtained by a single factor experiment, adding 2% Protamex and performing enzymolysis for 3 h with a liquid–material ratio of 35:1. The dose–response relationship experiment showed that 800 mg/kg·bw EPs played a better role in facilitating alcohol metabolism. EPs contained 40% hydrophobic amino acids (HAA), including 9.24% Leu. Eighty-four peptides were identified by HPLC-MS/MS and four peptides with potential activation of alcohol dehydrogenase were further selected by molecular docking. The tetrapeptide Trp-Ile-Val-Asp (WIVD) with the highest binding energy reached −7.16 kcal/mol. These findings suggest that egg is a good source for the preparation of peptides with facilitating alcohol metabolism activity.

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Section: Introductionmentioning

confidence: 99%