In pregnant women with a history of depression, does the use of a selective norepinephrine reuptake inhibitor during pregnancy increase the risk of congenital malformation compared with a selective serotonin reuptake inhibitor?

Abstract

above. Patients were club soccer players between seven and 12 years from Switzerland, Germany, the Czech Republic, and the Netherlands. Patients were excluded if they already used a warm-up focused on neuromuscular control. Patients were randomized to either warm-up as usual (n51,829) or the FIFA 11+ Kids program (n52,066). It should be noted that the FIFA11+ Kids program contained some different elements than the basic FIFA 11+, which addressed developmental and age-appropriate motor skills. The primary outcome was the overall risk of injuries. Compared with the control group, the overall injury rate in the intervention group was reduced by 48% (hazard ratio [HR] 0.52; 95% CI, 0.3220.86). Injuries requiring greater than 28 days off (HR 0.26; 95% CI 0.1020.64) and lower extremity injuries (HR 0.45; 95% CI, 0.24-0.84) were also significantly lower in the intervention group. Limitations included a lower proportion of girls and difficulty in blinding participants.