In pursuit of objective dry eye screening clinical techniques

Kanellopoulos, Anastasios John; Asimellis, George

doi:10.1186/s40662-015-0032-4

Cited by 36 publications

(21 citation statements)

References 79 publications

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“…The lack of reliable diagnosis due to a bedeviled assessment of dry eye syndrome might be secondary to poor diagnostic repeatability, which is manifested as significant false-positive/negative rates, broad range of variability, wide range of sensitivity and specificity, and dependence on clinical conditions [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of dry eye syndrome in residents of surgical specialties

et al. 2016

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BackgroundThe aim of this study was to determine the prevalence and severity of dry eye syndrome in a group of Mexican residents of different surgical specialties.MethodsA cross-sectional descriptive study where the residents were studied using the Ocular Surface Disease Index, together with diagnostic tests for dry eye syndrome, such as tear breakup time, Oxford Schema, Schirmer’s test I, and meibomian gland dysfunction testing. Statistical analyses were performed by Pearson’s chi-squared test for categorical variables and student’s t-test for quantitative variables. Any P value < 0.05 was considered statistically significant.ResultsOne hundred and twenty-three residents were included (246 eyes); 90 (73 %) were male and 33 (27 %) were female. The mean age was 27.8 ± 2.1 years. A higher number of residents with dry eye syndrome was found in the cardiothoracic surgery (75 %) and otorhinolaryngology (71 %) specialties; 70 % of them reported ocular symptoms, with teardrop quality involvement in >50 % of them.ConclusionsWe found a prevalence of 56 % for mild-to-moderate/severe stages of the condition. Their presence in the operating room predisposes surgical residents to dry eye syndrome because of environmental conditions.

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Section: Discussionmentioning

confidence: 99%

Prevalence of dry eye syndrome in residents of surgical specialties

et al. 2016

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“…DED results from either a systemic immunologic disorder known as Sjögren’s syndrome 3 in which there is insufficient production of moisture in the salivary and tear-producing glands, or from the low production or high evaporation of tears caused by other means 4 . Its severity may range from mild/episodic to severe/chronic and the disease is characterized by several symptoms including visual disturbance (blurred and fluctuating vision), foreign-body sensation and eye discomfort, irritation, ocular surface inflammation, redness, excess tearing, and photophobia 5 . DED is treated with a range of proprietary eye drops which contain a variety of active ingredients.…”

Section: Introductionmentioning

confidence: 99%

Toxic effects of selected proprietary dry eye drops on Acanthamoeba

Sifaoui

Reyes-Batllé

López-Arencibia

et al. 2018

Sci Rep

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Amoebae of the genus Acanthamoeba are ubiquitous protists that have been isolated from many sources such as soils, water and the air. They are responsible for infections including fatal encephalitis and a severe keratitis in humans. To date, there is no satisfactorily effective therapeutic agent against this pathogen and the infections it causes are exacerbated by the existence of a resistant cyst stage produced by this amoeba. As dry eye syndrome is a risk factor for Acanthamoeba keratitis, we aimed to evaluate the anti-Acanthamoeba activity of a variety of proprietary eye drops intended to treat dry eye syndrome. From the nine eye drop formulations tested, “Systane Ultra” was determined to be the most active against all tested Acanthamoeba strains. During our investigations into the mode of action of Systane Ultra, we discovered that it decreases mitochondrial membrane potential and ATP levels, induces chromatin condensation, and increases the permeability of the plasma-membrane.

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“…A study by Kanellopoulos et al found a statistical significantly epithelial thickness difference of 6.5 µm between women with dry eye compared with controls. 29 Practical pearls…”

Section: Corneal Evaluationmentioning

confidence: 99%

Diagnostic Tools for Dry Eye Disease

Wood¹

2016

European Ophthalmic Review

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Dry eye disease is multifactorial in aetiology and complex in pathophysiology that makes its diagnosis clinically challenging. Although there are numerous tools for assessment of dry eye disease, no single test is sufficient for the diagnosis. Typically a combination of subjective symptoms and objective tests are used. The aim of this article is to review the available tests, including traditional tools and emerging technologies. This review includes a description of the test methodology, type of data collected, diagnostic reliability of data, benefits and limitations of each test, expected outcomes and tips for practical application.

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In pursuit of objective dry eye screening clinical techniques

Cited by 36 publications

References 79 publications

Prevalence of dry eye syndrome in residents of surgical specialties

Prevalence of dry eye syndrome in residents of surgical specialties

Toxic effects of selected proprietary dry eye drops on Acanthamoeba

Diagnostic Tools for Dry Eye Disease

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