In rats, oral oleoyl-DHEA is rapidly hydrolysed and converted to DHEA-sulphate

Serrano, Marta; Grasa, María del Mar; Fernández-López, José Antonio

doi:10.1186/1471-2210-7-4

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…This hypothesis is reinforced by the observation that oleoyl‐DHEA, i.e. the substitution of estrone by another 17‐keto steroid results in the practically quantitative hydrolysis of the compound, with a fast kinetics of plasma levels of DHEA, a significant difference with the case for estrone.…”

Section: Oe Intestinal Uptake Hydrolysis and The Formation Of The Omentioning

confidence: 99%

Oleoyl‐Estrone

Remesar

Fernández-López

Alemany

2011

Medicinal Research Reviews

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Oleoyl-estrone (OE) is a powerful slimming agent that is also present in plasma and adipose tissue, where it is synthesized. It acts through the formation of a derivative W. OE effects (and W levels) are proportional to the dose. OE reduces food intake but maintains energy expenditure (thermogenesis). The energy gap is fulfilled with adipose tissue fat, sparing body protein and maintaining glycemia (and glycogen) with lower insulin and leptin levels. OE (in fact W) acts through specific receptors, different from those of estrogen. OE increases cholesterol catabolism, reducing hypercholesterolemia in obese rats. The main metabolic effect on adipose tissue is lowering of lipid synthesis, maintaining unchanged the intracellular lipolytic processes; the imbalance favors the progressive loss of fat, which is largely used by the muscle. OE administration induces additive effects with other antiobesity agents, such as β(3)-adrenergic agonists, forcing a massive loss of lipid. Corticosteroids markedly limit OE action by altering the liver control of lipogenesis. OE also inhibits the action of 17β-hydroxysteroid dehydrogenase, decreasing the synthesis of β-estradiol and testosterone. Discontinuous treatment allows for maximal efficacy both in rats and humans. OE has the advantage that the loss of fat is maintained and does not require additional dietary limitations.

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Section: Oe Intestinal Uptake Hydrolysis and The Formation Of The Omentioning

confidence: 99%

Oleoyl‐Estrone

Remesar

Fernández-López

Alemany

2011

Medicinal Research Reviews

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“…A testosterona administrada por via oral é rapidamente absorvida, entretanto, é extensivamente biotransformada no fígado, antes de alcançar a circulação sistêmica (KENNEDY, 2000;SERRANO et al, 2007). (HARDMAN et al, 1996;MOTTRAM & GEORGE, 2000;KARILA, 2003).…”

Section: Farmacocinética Dos Eaaunclassified

“…A testosterona é rapidamente metabolizada no fígado e 90% de seus metabólitos são excretados na urina (SMITH et al, 1985;RANG et al, 1997;CORRIGAN, 1999;KENNEDY, 2000, SERRANO et al, 2007.…”

Section: Farmacocinética Dos Eaaunclassified

Influência dos esteróides anabólicos androgênicos em aspectos do metabolismo de quilomícrons

Morikawa¹

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Significance of p53, pRb and Ki-67 markers in Cervical intraepithelial lesion and Malignancy

2015

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Abstract-Objective:To study and to derive the significance of expression of p53, pRb and Ki-67 markers in various grades of cervical intraepithelial lesions and malignancy in a tertiary hospital situated in southern part of India which caters the rural and semi-urban population.Methods: A total of 120 cervical tissue samples were included. These represented normal, dysplasia and malignancy. Immunohistochemical staining was performed for p53, Ki-67 and pRb in formalin-fixed, paraffin-embedded tissue sections of the uterine cervix using horse-peroxidase method. Descriptive statistical analysis was done; significance was assessed at 5% level of significance. The mean value of the markers was compared between normal and pathological lesions separately using Independent "t" test. Results: There was significant association of p53 expression between normal cervical epithelium and low grade squamous intraepithelial lesion (LSIL) (p=0.023), squamous cell carcinoma (SCC) (p<0.001) and adenocarcinoma AC (p=0.004), but no significant association with high grade squamous intraepithelial lesion (HSIL) (p=0.09). In case of pRb(n) (n=nuclear) expression significant association was found when normal was compared with LSIL (p<0.001) and HSIL (p=0.001), no association was found with SCC (p=0.207) and AC (p=0.322). pRb(c) (c=cytoplasmic) expression showed significant association when normal was compared with HSIL(p=0.03), SCC (p<0.001) and AC (p<0.001), but no association was found with LSIL. Whereas Ki-67 expression showed highly significant association with LSIL (p=0.012), HSIL (p<0.001), SCC (p<0.001) and AC (p<0.001). Conclusion: p53 expression progressively increased from normal cervical epithelium to intraepithelial lesion to malignant lesion. pRb expression showed shift of expression of pRb(n) in intraepithelial lesions to expression of pRb(c) in HSIL to frank malignancy. Ki-67 expression was directly proportional to the degree of dysplasia to malignant lesion.

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In rats, oral oleoyl-DHEA is rapidly hydrolysed and converted to DHEA-sulphate

Cited by 3 publications

References 41 publications

Oleoyl‐Estrone

Oleoyl‐Estrone

Influência dos esteróides anabólicos androgênicos em aspectos do metabolismo de quilomícrons

Significance of p53, pRb and Ki-67 markers in Cervical intraepithelial lesion and Malignancy

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