In Reply: The Impact of Extent of Ablation on Survival of Patients With Newly Diagnosed Glioblastoma Treated With Laser Interstitial Thermal Therapy: A Large Single-Institutional Cohort

Kaisman-Elbaz, Tehila; Xiao, Tianqi; Grabowski, Matthew M.; Barnett, Gene H.; Mohammadi, Alireza

doi:10.1227/neu.0000000000002622

Neurosurgery

2023

DOI: 10.1227/neu.0000000000002622

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In Reply: The Impact of Extent of Ablation on Survival of Patients With Newly Diagnosed Glioblastoma Treated With Laser Interstitial Thermal Therapy: A Large Single-Institutional Cohort

Tehila Kaisman-Elbaz

Tianqi Xiao

Matthew M. Grabowski

et al.

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2024

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Cited by 2 publications

References 3 publications

(11 reference statements)

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The LITT Fit in neuro-oncology: indications, imaging, and adjunctive therapies

Haskell-Mendoza,

Gonzalez,

Reason

et al. 2024

J Neurooncol

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The LITT Fit in neuro-oncology: indications, imaging, and adjunctive therapies

Haskell-Mendoza,

Gonzalez,

Reason

et al. 2024

J Neurooncol

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Local therapy in glioma: An evolving paradigm from history to horizons (Review)

Ius,

Somma,

Pasqualetti

et al. 2024

Oncol Lett

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Despite the implementation of multimodal treatments after surgery, glioblastoma (GBM) remains an incurable disease, posing a significant challenge in neuro-oncology. In this clinical setting, local therapy (LT), a developing paradigm, has received significant interest over time due to its potential to overcome the drawbacks of conventional therapy options for GBM. The present review aimed to trace the historical development, highlight contemporary advances and provide insights into the future horizons of LT in GBM management. In compliance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols criteria, a systematic review of the literature on the role of LT in GBM management was conducted. A total of 2,467 potentially relevant articles were found and, after removal of duplicates, 2,007 studies were screened by title and abstract (Cohen's κ coefficient=0.92). Overall, it emerged that 15, 10 and 6 clinical studies explored the clinical efficiency of intraoperative local treatment modalities, local radiotherapy and local immunotherapy, respectively. GBM recurrences occur within 2 cm of the radiation field in 80% of cases, emphasizing the significant influence of local factors on recurrence. This highlights the urgent requirement for LT strategies. In total, three primary reasons have thus led to the development of numerous LT solutions in recent decades: i) Intratumoral implants allow the blood-brain barrier to be bypassed, resulting in limited systemic toxicity; ii) LT facilitates bridging therapy between surgery and standard treatments; and iii) given the complexity of GBM, targeting multiple components of the tumor microenvironment through ligands specific to various elements could have a synergistic effect in treatments. Considering the spatial and temporal heterogeneity of GBM, the disease prognosis could be significantly improved by a combination of therapeutic strategies in the era of precision medicine.

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In Reply: The Impact of Extent of Ablation on Survival of Patients With Newly Diagnosed Glioblastoma Treated With Laser Interstitial Thermal Therapy: A Large Single-Institutional Cohort

Cited by 2 publications

References 3 publications

The LITT Fit in neuro-oncology: indications, imaging, and adjunctive therapies

The LITT Fit in neuro-oncology: indications, imaging, and adjunctive therapies

Local therapy in glioma: An evolving paradigm from history to horizons (Review)

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