In Search for Symptoms of Impaired Function of Glymphatic System in Older People

Abstract

The authors emphasize significance for people caring for the elderly of the knowledge on the glymphatic system, discovered a few years ago They present the basic data about the contemporary possibilities of objective estimation of the function of this system. The authors postulate that it would be reasonable to search for clinical symptoms indicative for the impairment of function of glymphatic system in older people. They believe that it is possible to propose some candidatures of such symptoms on the basis of analysis of the content of interviews with elderly people suffering from ineffective sleep. They postulate also to review the known psychometric tests designed for sleep quality assessment. As results of these considerations they propose some possible indicative symptoms, however they emphasize that these propositions should be verified by neuroscientist, which can apply the contrastenhanced MRI.