In search of mechanisms to explain the unquestionable benefit derived from sodium-glucose cotransporter-2 (SGLT-2) inhibitors use in heart failure patients

López‐Candales, Angel; Sawalha, Khalid; Drees, Betty M.; Norgard, Nicholas B

doi:10.1080/00325481.2023.2181537

Cited by 2 publications

(2 citation statements)

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“…78,85,94 Numerous clinical studies have demonstrated that sodium-dependent glucose transporters 2 inhibitor is beneficial for patients with CVDs, such as HF and diabetic cardiomyopathy (DCM), and is closely related to mitochondrial LPO. 90,95,96 Although the studies covered in this article reflect a close link between ferroptosis and mitochondria, the relationship between the 2 has been controversial. It was found that although the target of erastin, VADC, is located in the mitochondria, there was no significant increase in mitochondrial ROS in erastin-treated cells, and no ferroptosis occurred in subsequent experiments.…”

Section: Discussionmentioning

confidence: 99%

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Ferroptosis Involved in Cardiovascular Diseases: Mechanism Exploration of Ferroptosis' Role in Common Pathological Changes

Gao,

Hu,

et al. 2024

Journal of Cardiovascular Pharmacology

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Regulated cell death is a controlled form of cell death that protects cells by adaptive responses in pathophysiological states. Ferroptosis has been identified as a novel method of controlling cell death in recent years. Several cardiovascular diseases (CVDs) are shown to be profoundly influenced by ferroptosis, and ferroptosis is directly linked to the majority of cardiovascular pathological alterations. Despite this, it is still unclear how ferroptosis affects the pathogenic alterations that take place in CVDs. Based on a review of the mechanisms that regulate ferroptosis, this paper explores the most recent research on the role of ferroptosis in the major pathological changes associated with CVDs, in order to provide new perspectives and strategies for cardiovascular research and clinical treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ferroptosis Involved in Cardiovascular Diseases: Mechanism Exploration of Ferroptosis' Role in Common Pathological Changes

Gao,

Hu,

et al. 2024

Journal of Cardiovascular Pharmacology

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Promoting Resilience—What Does the Science Say?

Stewart

2024

Sustainable Development Goals Series

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If the contents and topics covered thus far in this book have proved anything, it is that there is still little definitive science to guide us in relation to optimally managing people living with heart disease from a climatic perspective. And yet, there is ample epidemiological evidence to suggest why we need to change the paradigm of clinical management on this basis. Thus, the title of this chapter might have been extended with a ‘thus far’. Moreover, it could well have been structured with a list of (Donald Rumsfeld-inspired) “known-unknowns” and even “unknown, unknowns”. Nevertheless, there is sufficient evidence to start an important conversation around what clinicians operating within a tertiary healthcare setting can do to promote resilience in people presenting with various forms of heart disease. This is the major focus of this chapter, whist providing some critical reflections on where the evidence falls short in protecting people from both current climatic conditions and that resulting from future climatic change.

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In search of mechanisms to explain the unquestionable benefit derived from sodium-glucose cotransporter-2 (SGLT-2) inhibitors use in heart failure patients

Cited by 2 publications

References 37 publications

Ferroptosis Involved in Cardiovascular Diseases: Mechanism Exploration of Ferroptosis' Role in Common Pathological Changes

Ferroptosis Involved in Cardiovascular Diseases: Mechanism Exploration of Ferroptosis' Role in Common Pathological Changes

Promoting Resilience—What Does the Science Say?

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