In Search of Novel Degradation-Resistant Monomers for Adhesive Dentistry: A Systematic Review and Meta-Analysis

Mocharko, Vlasta; Mascarenhas, Paulo; Azul, Ana Cristina; Delgado, António H. S.

doi:10.3390/biomedicines10123104

Cited by 2 publications

(1 citation statement)

References 76 publications

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“…Other scholars have reduced water residues through extra-fiber demineralization and rapid intrafibrillar mineralization (Zhao et al 2022;Gao et al 2023). In addition, some researchers have developed hydrolysis-resistant resin monomers that effectively enhance durability at the bonding interface (Mocharko et al 2022).…”

Section: Introductionmentioning

confidence: 99%

New Monomer Capable of Dual Chemical Binding with Dentin to Improve Bonding Durability

Wang,

Li,

Tian

et al. 2024

J Dent Res

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The water-rich nature of the dentin bonding microenvironment, coupled with the stresses on the bonding interface, contributes to the hydrolytic degradation of the hybrid layer, resulting in a decline in bonding durability and, ultimately, restoration failure. Currently, the 3-step etch-and-rinse technique remains the gold standard for dentin bonding, and the bonding mechanism mainly involves a physical interaction with little chemical bonding. In this study, we have developed a siloxane-modified polyurethane monomer (SPU) with acrylate and siloxane modifications that chemically binds to both collagen and hydroxyapatite in dentin. Formulated as a bisphenol A-glycidyl methacrylate alternative, the SPU monomer-based adhesive was designed to improve dentin bonding quality and durability. Attenuated total reflection Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscope, and hydroxyproline release assays were performed on SPU-treated collagen, hydroxyapatite, and acid-etched dentin slices to dentin. The physicochemical properties of the configured SPU adhesives were profiled for polymerization behavior, water contact angle, and tensile strain and strength. The bonding effectiveness was assessed through micro-tensile strength, nano-leakage tests conducted on the bonded samples before and after thermal cycle aging. Finally, we further conducted in vivo and in vitro experiments to assess the biocompatibility of adhesives. The results showed that the siloxane groups of SPU monomer could covalently bind to dentin collagen and hydroxyapatite. The incorporation of SPU in the adhesive led to a significant increase in adhesive polymerization ( P < 0.05) and tensile strain at break up to 134.11%. Furthermore, the SPU adhesive significantly improved dentin bond strength ( P < 0.05), reduced interfacial nano-leakage ( P < 0.05), and displayed good biocompatibility. In conclusion, the application of SPU, which achieves dual chemical bonding with dentin, can improve the quality of the hybrid layer, buffer the interfacial stresses, enhance the interfacial resistance to hydrolysis, and provide a feasible strategy to extend the service life of adhesive restorations.

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Section: Introductionmentioning

confidence: 99%

New Monomer Capable of Dual Chemical Binding with Dentin to Improve Bonding Durability

Wang,

Li,

Tian

et al. 2024

J Dent Res

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Modern Trends and Perspectives of the Development of Adhesive Dentistry. Innovative Techniques for the Application of Adhesive Systems

Pompii,

Tkachenko,

Kerimova

et al. 2023

Wiad Lek

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The aim: To study the latest approaches to optimizing the composition and application protocols of modern adhesive systems, which are used during the restoration of defects in hard dental tissues with restorative materials. Materials and methods: Thirty articles published between January 1, 2020 and February 1, 2023 in the scientific databases PubMed, Scopus, and Google Scholar were selected. The selected scientific works contained the results of laboratory studies, systematic reviews, meta-analyses of the physical and mechanical characteristics of adhesive systems with a modified composition or application protocols different from the instructions of the manufacturing companies. Conclusions: The most promising directions for improving adhesive systems are modifications of the composition and protocols of their use with the aim of deactivating matrix metalloproteinases, improving the structure of the hybrid layer due to the creation of a three-dimensional mesh of collagen fibres with optimal properties, the introduction of antimicrobial agents to slow down the growth of bacterial colonies along the line of the adhesive joint. The available research results of modified adhesive systems are often contradictory, which determines the need to develop standardized test methods to obtain more reliable indicators of their physical, mechanical and biological properties. In some cases, the consequences of non-compliance with the recommendations of the manufacturing companies are a significant deterioration of the characteristics of the hybrid layer, adhesive strength, marginal fit, which, in turn, explains the need for further search for an optimized composition and techniques for applying bonding agents to improve the prognosis of restorative treatment.

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In Search of Novel Degradation-Resistant Monomers for Adhesive Dentistry: A Systematic Review and Meta-Analysis

Cited by 2 publications

References 76 publications

New Monomer Capable of Dual Chemical Binding with Dentin to Improve Bonding Durability

New Monomer Capable of Dual Chemical Binding with Dentin to Improve Bonding Durability

Modern Trends and Perspectives of the Development of Adhesive Dentistry. Innovative Techniques for the Application of Adhesive Systems

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