In Search of Solutions for Evidence Generation in Rehabilitation

Négrini, Stefano; Meyer, Thorsten; Arienti, Chiara; Malmivaara, Antti; Frontera, Walter R.; participants, Cochrane Rehabilitation Methodology Meeting

doi:10.1097/phm.0000000000001374

Cited by 11 publications

(6 citation statements)

References 24 publications

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“…Recently, Cochrane Rehabilitation Methodology Meetings have been organized with the aim to improve the methodology used in PMR to generate effective and translational evidence ( 20 ). In this context, the RCT Rehabilitation Checklists (RCTRACK) project have been proposed to develop specific guidelines specific for research conducted in rehabilitation ( 20 ), whose work is ongoing.…”

Section: Selecting the Appropriate Study Designmentioning

confidence: 99%

Common Bias and Challenges in Physical and Rehabilitation Medicine Research: How to Tackle Them

Thibaut

Beaudart

Martens

et al. 2022

Front. Rehabilit. Sci.

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The importance of evidence-based medicine is crucial, especially in physical and rehabilitation medicine (PRM), where there is a need to conduct rigorous experimental protocols, as in any medical field. Currently, in clinical practice, therapeutic approaches are often based on empirical data rather than evidence-based medicine. However, the field of PRM faces several challenges that may complicate scientific research. In addition, there is often a lack of appropriate research training in educational programs. In this context, we aim to review the methodological challenges in PRM and provide clear examples for each of them as well as potential solutions when possible. This article will cover the following themes: (1) Choosing the right study design and conducting randomized and benchmarking controlled trials; (2). Selecting the appropriate controlled, placebo or sham condition and the issue of blinding in non-pharmacological trials; (3) The impact of populations' heterogeneity and multi-comorbidities; (4). The challenge of recruitment and adherence; (5). The importance of homogeneity and proper quantification of rehabilitative strategies; and (6). Ethical issues. We are convinced that teaching the basics of scientific research in PRM could help physicians and therapists to choose a treatment based on (novel) scientific evidence. It may also promote scientific research in PRM to develop novel and personalized rehabilitation strategies using rigorous methodologies and randomized or benchmarking controlled trials in order to improve patients' management.

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Section: Selecting the Appropriate Study Designmentioning

confidence: 99%

Common Bias and Challenges in Physical and Rehabilitation Medicine Research: How to Tackle Them

Thibaut

Beaudart

Martens

et al. 2022

Front. Rehabilit. Sci.

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“…Rehabilitation comes partly during, but mostly after the acute phase of illness [6] . Moreover, rehabilitation research faces specific methodological challenges related to its: 1) multimodal approach which involves a combination of behavioural and physical interventions 7 , 8 , 9 ;2) multi-professional team approach [10] ; and 3) focus on optimizing individual functioning while accounting for multi-comorbidities of people who need rehabilitation 11 , 12 , 13 . These needs often result in delays in completing studies when compared to other fields of medicine.…”

Section: Introductionmentioning

confidence: 99%

A systematic review that is ``rapid'' and ``living'': A specific answer to the COVID-19 pandemic

Négrini

Ceravolo

Côté

et al. 2021

Journal of Clinical Epidemiology

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Objective This study aims to describe “rapid living” systematic reviews, an innovative methodological design used to systematically synthesize emerging evidence in the field of rehabilitation during the COVID-19 pandemic. Study design and setting A methodological paper, with a formative approach to rapid living systematic reviews. Results Based on our experience, we propose the following definition of rapid living SR: " A dynamic method of knowledge synthesis that allows for the constant updating of new emerging evidence and refinement of its methodological quality ". This method has the benefit of accelerating the conduct of traditional systematic reviews and allows for a synergistic adaptation of methodology based on the quality of the evidence with a flexibility to update results, methods and collaborations. Conclusion Our proposed methodology has been helpful to synthesize the rapidly evolving evidence in the field of rehabilitation during the pandemic. Similarly, it may be useful when a rapid answer is urgently needed to make informed decisions. The COVID-19 disease has shown that moderns medical science has the ability to produce new knowledge at a rate never seen before. Therefore, our proposed rapid living systematic reviews provides the scientific community with a method to rapidly synthesize evidence when facing health emergencies.

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“…The 4 th Cochrane Rehabilitation Methodology Meeting was the second Consensus Meeting of the RCTRACK project. The starting point was the results of the first meeting held in 2019 (7)(8)(9)(10) and was divided into 7 Technical Working Groups (1). The work of these groups was presented and discussed over 2 days, thanks to funding support from the International Society of Physical and Rehabilitation Medicine (ISPRM).…”

mentioning

confidence: 99%

Current evidence from the Randomized Controlled Trials Rehabilitation Checklist (RCTRACK) reporting guideline project

Négrini

Chan

Ferriero

et al. 2021

Eur J Phys Rehabil Med

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In Search of Solutions for Evidence Generation in Rehabilitation

Cited by 11 publications

References 24 publications

Common Bias and Challenges in Physical and Rehabilitation Medicine Research: How to Tackle Them

Common Bias and Challenges in Physical and Rehabilitation Medicine Research: How to Tackle Them

A systematic review that is ``rapid'' and ``living'': A specific answer to the COVID-19 pandemic

Current evidence from the Randomized Controlled Trials Rehabilitation Checklist (RCTRACK) reporting guideline project

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