In silico analysis of the predicted protein-protein interaction of syntaxin-18, a putative receptor of <i>Peregrinus maidis</i> Ashmead (Hemiptera: <i>Delphacidae</i>) with Maize mosaic virus glycoprotein

Castrosanto, Melvin A.; Clemente, Apel Jae; Whitfield, Anna E.; Alviar, Karen B.

doi:10.1080/07391102.2022.2059569

Cited by 3 publications

(1 citation statement)

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“…These interactions facilitated the accumulation of RSV in SBPH [31]. In silico analysis of interactions between glycoprotein of MMV and Syntaxin-18 (PmStx18) of corn planthopper (P. maidis) revealed PmStx18 as a putative receptor of MMV [32] (Figure 2). These receptor proteins will provide new clues for studies of the complicated relationship between viruses and vectors by planthoppers.…”

Section: Planthopper and Leafhopper-associated Virus Receptorsmentioning

confidence: 99%

Deciphering the Role of Virus Receptors in Plant–Virus–Vector Interactions

Jangra,

Chinnaiah,

Patil

et al. 2024

Receptors

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Insect-transmitted plant viruses are a major threat to global agricultural crop production. Receptors play a prominent role in the interplay between host-pathogen and vector interaction. The virus–vector relationship involves both viral and vector receptors. Receptors-like kinases (RLKs) and receptor-like proteins play a crucial role in plant immunity, which acts as a basal defense. Pathogens can evade or block host recognition by their effector proteins to inhibit pathogen recognition receptor (PRR)-mediated signaling. Intriguingly, RLKs are also known to interact with viral proteins and impact plant susceptibility against viruses, while the endocytic receptors in vectors assist in the binding of the virus to the vectors. Unlike other receptors of fungi and bacteria which have three different domains located from extracellular or intracellular to perceive a multitude of molecular patterns, the characterization of viral receptors is quite complex and limited since the virus is directly injected into plant cells by insect vectors. Little is known about these receptors. Unraveling the receptors involved in virus entry and transmission within the vector will provide vital information in virus–vector interactions. This review focuses on efforts undertaken in the identification and characterization of receptors of plant viruses within the host and vector. This will lead to a better understanding of the cellular mechanism of virus transmission and spread, and further suggests new alternative tools for researchers to develop an integrated approach for the management of viral diseases and associated vectors.

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Section: Planthopper and Leafhopper-associated Virus Receptorsmentioning

confidence: 99%

Deciphering the Role of Virus Receptors in Plant–Virus–Vector Interactions

Jangra,

Chinnaiah,

Patil

et al. 2024

Receptors

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Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors

et al. 2022

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Cell cycle dysregulation is a characteristic hallmark of malignancies, which results in uncontrolled cell proliferation and eventual tumor formation. Cyclin-dependent kinase 1 (CDK1) is a member of the family of cell cycle regulatory proteins involved in cell cycle maintenance. Given that overexpression of CDK1 has been associated with cancer, CDK1 inhibitors may restore equilibrium to the skewed cell cycle system and operate as an effective therapeutic drug. This study aimed to identify and classify inhibitors having a higher affinity for CDK1 and also evaluate the expression pattern and prognostic relevance of CDK1 in a wide range of cancers. We investigated therapeutic molecules structurally similar to dinaciclib for their ability to inhibit CDK1 selectively. To assess the therapeutic potential of screened Dinaciclib analogs, we used drug likeliness analysis, molecular docking, and simulation analysis. CDK1 was found to be highly upregulated across several malignancies and is associated with poor overall and relapse-free survival. Molecular docking and dynamics evaluation identified two novel dinaciclib analogs as potent CDK1 inhibitors with high binding affinity and stability compared to dinaciclib. The results indicate that increased CDK1 expression is associated with decreased OS and RFS. Additionally, dinaciclib analogs are prospective replacements for dinaciclib since they exhibit increased binding affinity, consistent with MDS findings, and have acceptable ADMET qualities. The discovery of new compounds may pave the road for their future application in cancer prevention through basic, preclinical, and clinical research. Supplementary Information The online version contains supplementary material available at 10.1007/s12032-022-01748-2.

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