In silico and in vitro study of magnetic niosomes for gene delivery: The effect of ergosterol and cholesterol

Barani, Mahmood; Nematollahi, Mohammad Hadi; Zaboli, Maryam; Mirzaei, Mohammad; Torkzadeh‐Mahani, Masoud; Pardakhty, Abbas; Karam, Gholamreza Asadi

doi:10.1016/j.msec.2018.09.026

Cited by 78 publications

(33 citation statements)

References 57 publications

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“…Recently, the utilization of natural polymers has increased [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. The use of natural plant-derived polysaccharides as excipients has increased in the pharmaceutical industry and can solve formulation problems and reduce the side effects of synthetic polymers [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review

et al. 2021

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Gums are carbohydrate biomolecules that have the potential to bind water and form gels. Gums are regularly linked with proteins and minerals in their construction. Gums have several forms, such as mucilage gums, seed gums, exudate gums, etc. Plant gums are one of the most important gums because of their bioavailability. Plant-derived gums have been used by humans since ancient times for numerous applications. The main features that make them appropriate for use in different applications are high stabilization, viscosity, adhesive property, emulsification action, and surface-active activity. In many pharmaceutical formulations, plant-based gums and mucilages are the key ingredients due to their bioavailability, widespread accessibility, non-toxicity, and reasonable prices. These compete with many polymeric materials for use as different pharmaceuticals in today’s time and have created a significant achievement from being an excipient to innovative drug carriers. In particular, scientists and pharmacy industries around the world have been drawn to uncover the secret potential of plant-based gums and mucilages through a deeper understanding of their physicochemical characteristics and the development of safety profile information. This innovative unique class of drug products, useful in advanced drug delivery applications, gene therapy, and biosynthesis, has been developed by modification of plant-based gums and mucilages. In this review, both fundamental and novel medicinal aspects of plant-based gums and mucilages, along with their capacity for pharmacology and nanomedicine, were demonstrated.

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Section: Introductionmentioning

confidence: 99%

Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review

et al. 2021

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“…First, the transfection efficiency and targetability are greatly enhanced. Magnetic gene vectors are observed to permeate the plasma membrane of cells selectively and smoothly both in vitro and in vivo, due to their sensitive magnetic response and precise guidance from magnetic fields . Second, the surface of ferromagnetic particles could be easily tailored and modified, making them suitable to connect with numerous biomolecules .…”

Section: Ferrofluid‐based Detection Diagnosis and Therapymentioning

confidence: 99%

Flexible Ferrofluids: Design and Applications

et al. 2019

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Ferrofluids, also known as ferromagnetic particle suspensions, are materials with an excellent magnetic response, which have attracted increasing interest in both industrial production and scientific research areas. Because of their outstanding features, such as rapid magnetic reaction, flexible flowability, as well as tunable optical and thermal properties, ferrofluids have found applications in various fields, including material science, physics, chemistry, biology, medicine, and engineering. Here, a comprehensive, in‐depth insight into the diverse applications of ferrofluids from material fabrication, droplet manipulation, and biomedicine to energy and machinery is provided. Design of ferrofluid‐related devices, recent developments, as well as present challenges and future prospects are also outlined.

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“…Any slight change of any of the four chemical domains of cationic lipids influences the transfection efficacy mediated by niosomes [49]. Regarding "helper" lipids, they are normally neutral components i.e., cholesterol, that when used in appropriate amounts enhance both the rigidity and the colloidal stability of formulations, promoting the gel liquid transition temperature of niosomes and the interactions with the apolar group of non-ionic surfactants [89]. In addition, they can affect biological parameters such as the cellular uptake and posterior intracellular trafficking of niosomes [90].…”

Section: Components On Niosome Formulationsmentioning

confidence: 99%

Niosome-Based Approach for In Situ Gene Delivery to Retina and Brain Cortex as Immune-Privileged Tissues

et al. 2020

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Non-viral vectors have emerged as a promising alternative to viral gene delivery systems due to their safer profile. Among non-viral vectors, recently, niosomes have shown favorable properties for gene delivery, including low toxicity, high stability, and easy production. The three main components of niosome formulations include a cationic lipid that is responsible for the electrostatic interactions with the negatively charged genetic material, a non-ionic surfactant that enhances the long-term stability of the niosome, and a helper component that can be added to improve its physicochemical properties and biological performance. This review is aimed at providing recent information about niosome-based non-viral vectors for gene delivery purposes. Specially, we will discuss the composition, preparation methods, physicochemical properties, and biological evaluation of niosomes and corresponding nioplexes that result from the addition of the genetic material onto their cationic surface. Next, we will focus on the in situ application of such niosomes to deliver the genetic material into immune-privileged tissues such as the brain cortex and the retina. Finally, as future perspectives, non-invasive administration routes and different targeting strategies will be discussed.

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In silico and in vitro study of magnetic niosomes for gene delivery: The effect of ergosterol and cholesterol

Cited by 78 publications

References 57 publications

Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review

Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review

Flexible Ferrofluids: Design and Applications

Niosome-Based Approach for In Situ Gene Delivery to Retina and Brain Cortex as Immune-Privileged Tissues

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