In silico identification of excretory/secretory proteins and drug targets in monogenean parasites

Caña-Bozada, Víctor; Chapa-López, Martha; Díaz-Martín, Rubén D.; García‐Gasca, Alejandra; Huerta‐Ocampo, José Ángel; Anda-Jáuregui, Guillermo de; Morales-Serna, Francisco Neptalí

doi:10.1016/j.meegid.2021.104931

Cited by 9 publications

(9 citation statements)

References 93 publications

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“…cichlidarum infection 346 and identification of major histocompatibility complex II α alleles associated with parasite resistance make genotype‐assisted selection of resistant fish strains possible 347 . Bioinformatic analysis of monogenean parasite excretory/secretory proteins (secretomes) also provides a novel approach to identify potential drug targets 348 . The lack of reports of detrimental effects may be a consequence of a lack of study 349 and greater attention paid to pathogens of more immediate concern.…”

Section: Parasitic Infections Of Tilapiamentioning

confidence: 99%

“…347 Bioinformatic analysis of monogenean parasite excretory/secretory proteins (secretomes) also provides a novel approach to identify potential drug targets. 348 The lack of reports of detrimental effects may be a consequence of a lack of study 349 and greater attention paid to pathogens of more immediate concern. More functional-biological research on monogenean life history and infection dynamics, physiology, including host detection and environmental tolerance, and pathogenicity such as attachment and histopathology, and facilitation of secondary infections would benefit aquaculture.…”

Section: Researchmentioning

confidence: 99%

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A global review of problematic and pathogenic parasites of farmed tilapia

Shinn

Avenant‐Oldewage

Bondad‐Reantaso

et al. 2023

Reviews in Aquaculture

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Over the past 80 years, tilapia have been translocated globally for aquaculture; active production is recorded in >124 countries. Of 7 million tonnes of tilapia produced in aquaculture, 79% is from 79 countries outside the natural range of tilapia. Capture fisheries account for a further 723,627 tonnes of tilapia, and >47% of this is landed from established invasive populations outside Africa. Tilapias host a rich fauna of parasites, many of which have been translocated with their hosts. This review summarises >2500 host–parasite records from 73+ countries and >820 recorded tilapia translocations (provided in the supplementary materials). This work focuses on the notable pathogens that threaten the health of cultured populations of tilapia, providing a description of their pathology and includes species that also have substantial impacts on wild tilapia populations, where relevant. For each major parasite taxonomic group, we highlight which parasites have been translocated or have been acquired from the new environments into which tilapia have been introduced, together with remarks on standard treatment approaches and research on them and their management and control. Regarding the theme ‘Tilapia health: quo vadis?’, Africa has enormous potential for aquaculture growth, but substantial knowledge gaps about tilapia parasites in many African states remain, which creates associated production and biosecurity risks. For each parasitic group, therefore, the risks of parasite translocation to new regions as tilapia aquaculture industries expand are highlighted.

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Section: Parasitic Infections Of Tilapiamentioning

confidence: 99%

Section: Researchmentioning

confidence: 99%

A global review of problematic and pathogenic parasites of farmed tilapia

Shinn

Avenant‐Oldewage

Bondad‐Reantaso

et al. 2023

Reviews in Aquaculture

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“…ES proteins (representing the “secretome”) were inferred from the nuclear genome of the ISE strain of H. contortus (see [49] ; accession: PRJEB506; available via https://parasite.wormbase.org/ ; [64] ) employing published methods (cf. [65] , [66] , [67] ). All proteins containing a signal peptide and no transmembrane domain (i.e.…”

Section: Methodsmentioning

confidence: 99%

An informatic workflow for the enhanced annotation of excretory/secretory proteins of Haemonchus contortus

Zheng¹,

Young²,

Song³

et al. 2023

Computational and Structural Biotechnology Journal

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“…Nuestros primeros resultados indican que los monogéneos tienen cientos de PES. En Gyrodactylus salaris, encontramos 15 que parecen indispensables para mantener vivo al parásito (Caña-Bozada et al, 2021b). Actualmente, seguimos generando y analizando datos para tener resultados más específicos.…”

Section: Monogéneo Rhabdosynochus Viridisi Que Parasita Al Robalounclassified

Explorando el arsenal molecular de los parásitos de peces

Caña-Bozada

Morales-Serna

2022

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Los peces tienen una diversidad amplia de parásitos. Entre los más conocidos están los gusanos monogéneos, capaces de causar enfermedades y pérdidas económicas en la producción acuícola. Hay varias formas de combatir a estos parásitos, pero los resultados no son siempre satisfactorios. Entonces, es necesario continuar realizando investigaciones para encontrar formas más efectivas. Consideramos que la exploración del arsenal molecular que usan los monogéneos para atacar a los peces puede darnos pistas útiles. Entre ese arsenal están las proteínas excretoras/secretoras (PES), también conocidas como secretoma. Algunas de estas proteínas pueden ser indispensables para el parasitismo. Entonces, si encontramos esas proteínas en monogéneos, podríamos buscar fármacos para su inactivación, lo cual ayudaría a detener el desarrollo de enfermedades en el cultivo de peces.

show abstract

In silico identification of excretory/secretory proteins and drug targets in monogenean parasites

Cited by 9 publications

References 93 publications

A global review of problematic and pathogenic parasites of farmed tilapia

A global review of problematic and pathogenic parasites of farmed tilapia

An informatic workflow for the enhanced annotation of excretory/secretory proteins of Haemonchus contortus

Explorando el arsenal molecular de los parásitos de peces

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