2023
DOI: 10.1007/s00726-022-03202-z
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In silico identification of novel ACE and DPP-IV inhibitory peptides derived from buffalo milk proteins and evaluation of their inhibitory mechanisms

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Cited by 18 publications
(5 citation statements)
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“…In a very recent study, two new ACE‐inhibiting tripeptides (KPW and RGP) derived from in silico proteolysis of buffalo milk proteins were selected. [ 34 ] In order to evaluate the ACE‐inhibiting activity, tripeptides were synthesized in vitro. The peptides acted as competitive inhibitors of ACE, giving values of IC50 = 136.28 ± 10.77 µ m and IC50 = 104.72 ± 8.37 µ m for KPW and RGP, respectively.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…In a very recent study, two new ACE‐inhibiting tripeptides (KPW and RGP) derived from in silico proteolysis of buffalo milk proteins were selected. [ 34 ] In order to evaluate the ACE‐inhibiting activity, tripeptides were synthesized in vitro. The peptides acted as competitive inhibitors of ACE, giving values of IC50 = 136.28 ± 10.77 µ m and IC50 = 104.72 ± 8.37 µ m for KPW and RGP, respectively.…”
Section: Resultsmentioning
confidence: 99%
“…The inhibiting activity of RGP and KPW was probably due to binding to the ligand‐binding pocket of the ACE through hydrophobic interactions or hydrogen bonds. Furthermore, the RGP peptide showed proline as the C‐terminus amino acid, which is characteristic of ACE‐inhibiting peptides [ 34 ] ; however, it is important to remark that this study did not involve any clinical trial, so further studies should be performed to confirm the role of KPW and RGP to treat HT.…”
Section: Resultsmentioning
confidence: 99%
“…Hypertension is a well‐known global health problem that is physiologically linked to the control of blood pressure, and it has been associated with ACE. Numerous studies have been conducted on the antihypertensive effects of bioactive peptides derived from bovine milk proteins (Gu et al, 2023; Korhonen, 2006; Li et al, 2019). The CPH and WPH peptides were purified through RP‐HPLC and were tested for their ability to inhibit ACE activity as depicted in Figure 9b.…”
Section: Resultsmentioning
confidence: 99%
“…In a study conducted by Gu et al, five novel peptides were identified through in silico proteolysis of buffalo milk proteins. [11]. Moreover, the umami peptide IPIPATKT, obtained from Sanhuang chicken hydrolysate, demonstrated potential as a peptide with IC50 values of 265 μM and 64 μM for ACE and DPP-IV inhibitory activities, respectively [18].…”
Section: Bioactivities Of Peptides Through In Vitro Assaymentioning
confidence: 98%