In-Silico Interaction of Hydroxychloroquine Drug with Various Proteins of Coronavirus (SARS-CoV-2): A Computational Approaches to Combat COVID-19

Abstract

<p><i>In silico</i> docking study showed that hydroxychloroquine drug interactions with SARS-CoV2 show a higher binding affinity with spike glycoprotein and PLPRO protein compared to protein envelopes that could be ladder for potential targeting and synthesizing of another aniviral drug. <i>In silico</i> methods used in this study, the efficacy of a wide variety of repositioned and/or novel drug candidates could also be tested prior to clinical evaluation.</p>