In silico investigation on the mutational analysis of BRCA1-BARD1 RING domains and its effect on nucleosome recognition and ubiquitination

Sarma, Himakshi; Kiewhuo, Kikrusenuo; Jamir, Esther; Sastry, G. Narahari

doi:10.1016/j.bpc.2023.107070

Cited by 5 publications

(2 citation statements)

References 62 publications

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“…The RING domain in the BRCA1-BARD1 protein orients the UBE2D3 protein towards the ubiquitination of H2A for homologous recombination to repair DNA double-strand breaks[ 29 ]. Moreover, mutations in the BRCA1-BARD1 RING domain have been linked to familial breast and ovarian cancer, showing that structural compactness and reduced significant interactions may be a possible reason for cancer by preventing ubiquitination and hindering DNA repair[ 30 ].…”

Section: Discussionmentioning

confidence: 99%

High-grade serous carcinoma of the fallopian tube in a young woman with chromosomal 4q abnormality: A case report

Zhang,

Chu,

Ding

2024

World J Clin Cases

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BACKGROUND Few studies have reported an association between an increased risk of acquiring cancers and survival in patients with 4q deletion syndrome. This study presents a rare association between chromosome 4q abnormalities and fallopian tube high-grade serous carcinoma (HGSC) in a young woman. CASE SUMMARY A 35-year-old woman presented with acute dull abdominal pain and a known chromosomal abnormality involving 4q13.3 duplication and 4q23q24 deletion. Upon arrival at the emergency room, her abdomen appeared ovoid and distended with palpable shifting dullness. Ascites were identified through abdominal ultrasound, and computed tomography revealed an omentum cake and an enlarged bilateral adnexa. Blood tests showed elevated CA-125 levels. Paracentesis was conducted, and immunohistochemistry indicated that the cancer cells favored an ovarian origin, making us suspect ovarian cancer. The patient underwent debulking surgery, which led to a diagnosis of stage IIIC HGSC of the fallopian tube. Subsequently, the patient received adjuvant chemotherapy with carboplatin and paclitaxel, resulting in stable current condition. CONCLUSION This study demonstrates a rare correlation between a chromosome 4q abnormality and HGSC. UBE2D3 may affect crucial cancer-related pathways, including P53, BRCA, cyclin D, and tyrosine kinase receptors, thereby possibly contributing to cancer development. In addition, ADH1 and DDIT4 may be potential influencers of both carcinogenic and therapeutic responses.

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Section: Discussionmentioning

confidence: 99%

High-grade serous carcinoma of the fallopian tube in a young woman with chromosomal 4q abnormality: A case report

Zhang,

Chu,

Ding

2024

World J Clin Cases

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“…They possess the ability to compete with antimicrobial peptides − whose mode of action involves the barrel-stave mechanism, , a mechanism resembling that of CPNTs integrated into lipid membranes. Consequently, CPNTs have the potential to emerge as a suitable candidate to address the escalating issue of antibiotic resistance ,, in today’s world. Hence, the distinctive attributes of CPNTs surmount the constraints associated with conventional nanotube materials, making them an attractive prospect for intricate molecular transport dynamics.…”

Section: Introductionmentioning

confidence: 99%

Exploring Cyclic Peptide Nanotube Stability Across Diverse Lipid Bilayers and Unveiling Water Transport Dynamics

Moral,

Paul

2023

Langmuir

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Cyclic Peptide Nanotubes (CPNTs) have emerged as compelling candidates for various applications, particularly as nanochannels within lipid bilayers. In this study, the stability of two CPNTs, namely 8 × [(Cys-Gly-Met-Gly)2] and 8 × [(Gly-Leu)4], are comprehensively investigated across different lipid bilayers, including 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), a mixed model membrane (POPE/POPG), and a realistic yeast model membrane. The results demonstrate that both CPNTs maintain their tubular structures in all lipid bilayers, with [(Cys-Gly-Met-Gly)2] showing increased stability over an extended period in these lipid membranes. The insertion of CPNTs shows negligible impact on lipid bilayer properties, including area per lipid, volume per lipid, and bilayer thickness. The study demonstrates that the CPNT preserves its two-line water movement pattern within all the lipid membranes, reaffirming their potential as water channels. The MSD curves further reveal that the dynamics of water molecules inside the nanotube are similar for all the bilayer systems with minor differences that arise due to different lipid environments.

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Enhanced Disease Resistance Mechanism of the CmoAP2/ERF Transcription Factor in Pumpkin through Genetic Mutations

Rashmi,

Murmu,

Singh

et al. 2024

ACS Omega

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The squash species Cucurbita moschata has been historically utilized by both animals and humans as a food source. It is an annual dicotyledonous vegetable known for its health benefits, including reducing the risk of various diseases, such as cancer, high blood pressure, diabetes, intestinal disorders, and atherosclerosis, in humans. However, the cultivation of this valuable crop is often challenged by diseases such as powdery mildew (PM), caused by the fungus Podosphaera xanthii. PM not only reduces yield but also impacts photosynthesis rates. A newly identified gene called CmoCh3G009850, which encodes the transcription factor known as AP2-like ethylene-responsive factor (CmoAP2/ERF), has been marked for resistance against PM. A shift in the state from susceptible to resistant can be induced by nonsynonymous SNP mutations at five locations of the CmoCh3G009850 gene. The dynamical studies of the wild-type (WT) and mutated-type AP2/ERF proteins' interactions with DNA were explored by docking and molecular dynamics simulation studies. These five mutations T105A, S302R, H321R, H335D, and V402A are incorporated in the AP2/ERF transcription factor that makes a stable and compact complex with DNA rather than the WT protein. Overall, the identification and characterization of the CmoAP2/ERF gene and its variants represent a significant advancement for the breeding and cultivation of C. moschata varieties resistant against powdery mildew. This study not only enhances our understanding of plant−pathogen interactions but also provides a potential avenue for developing more resilient squash varieties through genetic improvement.

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In silico investigation on the mutational analysis of BRCA1-BARD1 RING domains and its effect on nucleosome recognition and ubiquitination

Cited by 5 publications

References 62 publications

High-grade serous carcinoma of the fallopian tube in a young woman with chromosomal 4q abnormality: A case report

High-grade serous carcinoma of the fallopian tube in a young woman with chromosomal 4q abnormality: A case report

Exploring Cyclic Peptide Nanotube Stability Across Diverse Lipid Bilayers and Unveiling Water Transport Dynamics

Enhanced Disease Resistance Mechanism of the CmoAP2/ERF Transcription Factor in Pumpkin through Genetic Mutations

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