In silico profiling of analgesic and antihyperglycemic effects of ethanolic leaves extract of Amischotolype mollissima: Evidence from in vivo studies

Medha, Maisha Maliha; Devnath, Hiron Saraj; Biswas, Biswajit; Bokshi, Bishwajit; Sadhu, Samir Kumar

doi:10.1016/j.sjbs.2022.103312

Cited by 6 publications

(3 citation statements)

References 48 publications

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“…Folin-Ciocalteu (FC) reagent was employed to assess TPC of plant extracts reported by Sarkar et al, 2022 [ 23 ] and Medha et al, 2022 [ 24 ], where gallic acid standard curve obtained from different concentrations in the range of 100–500 μg/mL, were used to estimate TPC and the findings were interpreted as milligram gallic acid equivalent per gram of dry extract (mg GAE/g).…”

Section: Methodsmentioning

confidence: 99%

Exploring antioxidative, cytotoxic and neuropharmacological insights into Bixa orellana leaves: Experimental and in silico approaches

Sarkar,

Mitra,

Aktaruzzaman

et al. 2024

Heliyon

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Section: Methodsmentioning

confidence: 99%

Exploring antioxidative, cytotoxic and neuropharmacological insights into Bixa orellana leaves: Experimental and in silico approaches

Sarkar,

Mitra,

Aktaruzzaman

et al. 2024

Heliyon

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“…The in vivo studies revealed that two compounds, coniferol and dillapiole, substantially lower blood glucose levels in albino mice. The ethanolic leaves extract of Amischotolype mollissima has shown α-glucosidase enzymatic activity in addition to the antihyperglycemic effect that was observed in the swiss albino mice oral glucose tolerance test in a dose-dependent manner [ 65 ]. The methanolic flower extract of Descurainia sophia showed in vitro α-glucosidase activity with mixed (competitive/non-competitive) inhibition [ 66 ].…”

Section: Plant Extracts As α-Glucosidase Inhibitor Sourcesmentioning

confidence: 99%

Recent Updates on Phytoconstituent Alpha-Glucosidase Inhibitors: An Approach towards the Treatment of Type Two Diabetes

Kashtoh

Baek

2022

Plants

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Diabetes is a common metabolic disorder marked by unusually high plasma glucose levels, which can lead to serious consequences such as retinopathy, diabetic neuropathy and cardiovascular disease. One of the most efficient ways to reduce postprandial hyperglycemia (PPHG) in diabetes mellitus, especially insulin-independent diabetes mellitus, is to lower the amount of glucose that is absorbed by inhibiting carbohydrate hydrolyzing enzymes in the digestive system, such as α-glucosidase and α-amylase. α-Glucosidase is a crucial enzyme that catalyzes the final stage of carbohydrate digestion. As a result, α-glucosidase inhibitors can slow D-glucose release from complex carbohydrates and delay glucose absorption, resulting in lower postprandial plasma glucose levels and control of PPHG. Many attempts have been made in recent years to uncover efficient α-glucosidase inhibitors from natural sources to build a physiologic functional diet or lead compound for diabetes treatment. Many phytoconstituent α-glucosidase inhibitors have been identified from plants, including alkaloids, flavonoids, anthocyanins, terpenoids, phenolic compounds, glycosides and others. The current review focuses on the most recent updates on different traditional/medicinal plant extracts and isolated compounds’ biological activity that can help in the development of potent therapeutic medications with greater efficacy and safety for the treatment of type 2 diabetes or to avoid PPHG. For this purpose, we provide a summary of the latest scientific literature findings on plant extracts as well as plant-derived bioactive compounds as potential α-glucosidase inhibitors with hypoglycemic effects. Moreover, the review elucidates structural insights of the key drug target, α-glucosidase enzymes, and its interaction with different inhibitors.

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“…The acetic acid-induced writhing model was followed to carry out the analgesic effect of the two fractions of J. aurea extract 10 . By comparing the experimental group to the control group, the percentage of writhing inhibition was calculated using the formula:…”

Section: Analgesic Activity Evaluationmentioning

confidence: 99%

Evaluation of Pharmacological Potentialities of Polar and Nonpolar Fractions of Justicia aurea Extract

Uddin¹,

Bokshi²,

Ahmed³

et al. 2022

IJPSRR

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This study aims to explore analgesic, antidiarrheal, neuropharmacological, and antibacterial activities of petroleum ether and water fractions of Justicia aurea (J. aurea). The results of analgesic activity showed that both nonpolar (petroleum ether) and polar (water) fractions of J. aurea extract at 250 and 500 mg/kg significantly suppressed the writhing reflex dose-dependently. Here, the potentiality of petroleum ether fraction was higher than that of water fraction. In the castor oil-induced diarrheal mice, both fractions of J. aurea extract, at 250 and 500 mg/kg, significantly delayed the onset of diarrhea and lessened the total number of feces in a dose-dependent manner. Of the two fractions, the nonpolar fraction was found to exhibit a better effect. Both fractions appreciably reduced the number of squares crossed by the mice at both 250 and 500 mg/kg. At 500 mg/kg, petroleum ether fraction reflected a slightly better effect than that of water fraction. In disc diffusion antibacterial assay, both fractions showed minor effects against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), however, only the water fraction exhibited low activity against Salmonella enterica (S. enterica). In conclusion, the nonpolar fraction of J. aurea. showed better analgesic, antidiarrheal, and CNS depression effects.

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In silico profiling of analgesic and antihyperglycemic effects of ethanolic leaves extract of Amischotolype mollissima: Evidence from in vivo studies

Cited by 6 publications

References 48 publications

Exploring antioxidative, cytotoxic and neuropharmacological insights into Bixa orellana leaves: Experimental and in silico approaches

Exploring antioxidative, cytotoxic and neuropharmacological insights into Bixa orellana leaves: Experimental and in silico approaches

Recent Updates on Phytoconstituent Alpha-Glucosidase Inhibitors: An Approach towards the Treatment of Type Two Diabetes

Evaluation of Pharmacological Potentialities of Polar and Nonpolar Fractions of Justicia aurea Extract

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