In silico toxicity studies of traditional Chinese herbal medicine: A mini review

Zulkifli, Muhammad Harith; Abdullah, Zafirah Liyana; Yusof, Nur Intan Saidaah Mohamed; Fauzi, Fazlin Mohd

doi:10.1016/j.sbi.2023.102588

Cited by 7 publications

(2 citation statements)

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“…Machine learning and network pharmacology were emerging technologies in the field of pharmacology. In the study of CHM, machine learning exists the potential in predicting toxicity ( Zulkifli et al, 2023 ), while network pharmacology could be utilized to compensate for the limitations of traditional research methods in understanding the multi-component synergism of CHM ( Yuan et al, 2017 ). Although landmark achievements in these 2 methods within CHM toxicity research are currently limited, they hold potential for future directions.…”

Section: Discussionmentioning

confidence: 99%

Growing attention on the toxicity of Chinese herbal medicine: a bibliometric analysis from 2013 to 2022

Zhu,

Wu,

Bian

et al. 2024

Front. Pharmacol.

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Introduction: Despite the clinical value of Chinese herbal medicine (CHM), restricted comprehension of its toxicity limits the secure and efficacious application. Previous studies primarily focused on exploring specific toxicities within CHM, without providing an overview of CHM’s toxicity. The absence of a quantitative assessment of focal points renders the future research trajectory ambiguous. Therefore, this study aimed to reveal research trends and areas of concern for the past decade.Methods: A cross-sectional study was conducted on publications related to CHM and toxicity over the past decade from Web of Science Core Collection database. The characteristics of the publication included publication year, journal, institution, funding, keywords, and citation counts were recorded. Co-occurrence analysis and trend topic analysis based on bibliometric analysis were conducted on keywords and citations.Results: A total of 3,225 publications were analyzed. Number of annal publications increased over the years, with the highest number observed in 2022 (n = 475). The Journal of Ethnopharmacology published the most publications (n = 425). The most frequently used toxicity classifications in keywords were hepatotoxicity (n = 119) or drug-induced liver injury (n = 48), and nephrotoxicity (n = 40). Co-occurrence analysis revealed relatively loose connections between CHM and toxicity, and their derivatives. Keywords emerging from trend topic analysis for the past 3 years (2019–2022) included ferroptosis, NLRP3 inflammasome, machine learning, network pharmacology, traditional uses, and pharmacology.Conclusion: Concerns about the toxicity of CHM have increased in the past decade. However, there remains insufficient studies that directly explore the intersection of CHM and toxicity. Hepatotoxicity and nephrotoxicity, as the most concerned toxicity classifications associated with CHM, warrant more in-depth investigations. Apoptosis was the most concerned toxicological mechanism. As a recent increase in attention, exploring the mechanisms of ferroptosis in nephrotoxicity and NLRP3 inflammasome in hepatotoxicity could provide valuable insights. Machine learning and network pharmacology are potential methods for future studies.

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Section: Discussionmentioning

confidence: 99%

Growing attention on the toxicity of Chinese herbal medicine: a bibliometric analysis from 2013 to 2022

Zhu,

Wu,

Bian

et al. 2024

Front. Pharmacol.

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“…In recent years, more and more scholars have pointed out that Chinese herbs have a feature of “multi-component, multi-target, multi-pathway”, which not only conforms to the holistic thinking in traditional Chinese medicine but also fits the complex and changeable process of diabetes and its complications. In addition, according to the research of modern pharmacology, Chinese herbs and their active compounds not only have broad biological activities (such as antioxidant, anti-inflammatory, and anti-tumor) ( Wang et al, 2013 ; Luo et al, 2019 ; Zhang Q. et al, 2021 ), but these substances have also been proven to be relatively safe, especially with less toxicity to liver and kidney ( Yang et al, 2018 ; Liu et al, 2020 ; Zulkifli et al, 2023 ). Therefore, Chinese herbs (including single-flavor drugs and compound formulations) and their active substances are increasingly considered alternative sources for regulating patients with diabetes and its complications ( Table 2 – 4 ).…”

Section: Active Compounds From Chinese Herbs Relieve Diabetic Vasculo...mentioning

confidence: 99%

Traditional Chinese medicine and its active substances reduce vascular injury in diabetes via regulating autophagic activity

Gao,

Zhang,

Zhang

et al. 2024

Front. Pharmacol.

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Due to its high prevalence, poor prognosis, and heavy burden on healthcare costs, diabetic vascular complications have become a significant public health issue. Currently, the molecular and pathophysiological mechanisms underlying diabetes-induced vascular complications remain incompletely understood. Autophagy, a highly conserved process of lysosomal degradation, maintains intracellular homeostasis and energy balance via removing protein aggregates, damaged organelles, and exogenous pathogens. Increasing evidence suggests that dysregulated autophagy may contribute to vascular abnormalities in various types of blood vessels, including both microvessels and large vessels, under diabetic conditions. Traditional Chinese medicine (TCM) possesses the characteristics of “multiple components, multiple targets and multiple pathways,” and its safety has been demonstrated, particularly with minimal toxicity in liver and kidney. Thus, TCM has gained increasing attention from researchers. Moreover, recent studies have indicated that Chinese herbal medicine and its active compounds can improve vascular damage in diabetes by regulating autophagy. Based on this background, this review summarizes the classification, occurrence process, and related molecular mechanisms of autophagy, with a focus on discussing the role of autophagy in diabetic vascular damage and the protective effects of TCM and its active compounds through the regulation of autophagy in diabetes. Moreover, we systematically elucidate the autophagic mechanisms by which TCM formulations, individual herbal extracts, and active compounds regulate diabetic vascular damage, thereby providing new candidate drugs for clinical treatment of vascular complications in diabetes. Therefore, further exploration of TCM and its active compounds with autophagy-regulating effects holds significant research value for achieving targeted therapeutic approaches for diabetic vascular complications.

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Chemical composition and toxicity of commercial Mentha spicata and Eucalyptus citriodora essential oils on Culex quinquefasciatus and non-target insects

Unni,

Kirupaanntha-Rajan,

Vasantha-Srinivasan

et al. 2024

Environ Sci Pollut Res

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In silico toxicity studies of traditional Chinese herbal medicine: A mini review

Cited by 7 publications

References 50 publications

Growing attention on the toxicity of Chinese herbal medicine: a bibliometric analysis from 2013 to 2022

Growing attention on the toxicity of Chinese herbal medicine: a bibliometric analysis from 2013 to 2022

Traditional Chinese medicine and its active substances reduce vascular injury in diabetes via regulating autophagic activity

Chemical composition and toxicity of commercial Mentha spicata and Eucalyptus citriodora essential oils on Culex quinquefasciatus and non-target insects

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