In situ administration of temperature-sensitive hydrogel composite loading paclitaxel microspheres and cisplatin for the treatment of melanoma

Liu, Yanlin; Ma, Wenqiong; Zhou, Ping; Wen, Qian; Wen, Qinglian; Lü, Yun; Zhao, Ling; Huan, Shi; Dai, Jie; Li, Jianmei; Shao, Fu

doi:10.1016/j.biopha.2023.114380

Cited by 11 publications

(6 citation statements)

References 42 publications

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“…This injectable, thermosensitive technology has the potential to be used as a therapy option for localized melanoma. [120] NSCs, which are versatile cells that play important roles in the development of neural lineage cells, have the potential to generate neurons for the treatment of SCI. [121] It is possible to treat SCI with NSC transplanting, but it is prone to leakage and needs external support.…”

Section: Scimentioning

confidence: 99%

Hydrogel nanoparticles as new drug delivery system for CNS disorders

Omar Khudhur,

Karimian,

Asadi

et al. 2024

ChemistrySelect

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Previous studies have shown that more than one million individuals suffer from central nervous system (CNS) diseases worldwide. Nanogels are a good way to deliver drugs because they are ultra‐stable, can hold a lot of drugs, have a core‐shell structure, are very permeable, and can get into brain tissue both in the lab and in living organisms. The blood‐brain barrier (BBB) and the blood‐cerebrospinal fluid barrier (BCSFB) make it harder to deliver therapies to specific areas of the CNS because drugs can′t get into the brain well enough. However, these barriers help treat neurological disorders like epilepsy, neurodegenerative diseases, brain tumors, and ischemic stroke. A number of biological studies suggest that nano‐additives may improve the shape, mechanical properties, electrical conductivity, and biological activities of hydrogels. The creation of nanogels for CNS drug delivery, their early preclinical success, and their potential for neurotoxicity are all examined in this research. This study looks at techniques that are almost ready for clinical use, a preclinical delivery system for the CNS, and the use of nanogels as a successful BBB‐penetration method. It also examines the main difficulties that nanogels must overcome in order to provide the most effective therapeutic care for CNS illnesses.

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Section: Scimentioning

confidence: 99%

Hydrogel nanoparticles as new drug delivery system for CNS disorders

Omar Khudhur,

Karimian,

Asadi

et al. 2024

ChemistrySelect

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“…3D). 87 Injectable hydrogels have been shown to be more suitable for intra-tumor drug therapy than traditional single carriers,…”

Section: Delivery Of Chemotherapeutic Agentsmentioning

confidence: 99%

Injectable hydrogels as emerging drug-delivery platforms for tumor therapy

Cheng,

Zhang,

Wei

et al. 2024

Biomater. Sci.

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“…To enhance effectiveness, platinum drugs are often combined with other anti-tumor medications. For instance, researchers developed paclitaxel-loaded PLA microspheres co-encapsulated with cisplatin in a heat-sensitive hydrogel for localized chemotherapy [ 74 ]. This temperature-sensitive system allows sustained drug release, and in vitro studies validated its ability to induce apoptosis and inhibit cell migration.…”

Section: Polymer Microspheres In Cancer Applicationsmentioning

confidence: 99%

Polymer Microspheres and Their Application in Cancer Diagnosis and Treatment

Zhai,

Wu,

Liao

et al. 2024

IJMS

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Cancer is a significant global public health issue with increasing morbidity and mortality rates. To address this challenge, novel drug carriers such as nano-materials, liposomes, hydrogels, fibers, and microspheres have been extensively researched and utilized in oncology. Among them, polymer microspheres are gaining popularity due to their ease of preparation, excellent performance, biocompatibility, and drug-release capabilities. This paper categorizes commonly used materials for polymer microsphere preparation, summarizes various preparation methods (emulsification, phase separation, spray drying, electrospray, microfluidics, and membrane emulsification), and reviews the applications of polymer microspheres in cancer diagnosis, therapy, and postoperative care. The current status and future development directions of polymer microspheres in cancer treatment are analyzed, highlighting their importance and potential for improving patient outcomes.

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In situ administration of temperature-sensitive hydrogel composite loading paclitaxel microspheres and cisplatin for the treatment of melanoma

Cited by 11 publications

References 42 publications

Hydrogel nanoparticles as new drug delivery system for CNS disorders

Hydrogel nanoparticles as new drug delivery system for CNS disorders

Injectable hydrogels as emerging drug-delivery platforms for tumor therapy

Polymer Microspheres and Their Application in Cancer Diagnosis and Treatment

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