In Situ Coacervated Microcapsules with Filled Polyelectrolytes and Charge‐Controlled Permeation for Dye Molecules

Wang, Zewei; Tong, Weijun; Li, Jun; Gao, Changyou

doi:10.1002/macp.200700537

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…The hydrophilic SPIO aqueous dispersion has a Zeta potential of −13.9 ± 4.87 mV. PSS, PAH, and SPIO are then used to prepare MCs by the LbL method (refer to experimental section) . After deposition of the desired layers, CaCO 3 particles are etched by EDTA (ethylenediaminetetraacetic acid) to yield the hollow center for DOX loading ( Scheme ).…”

Section: Resultsmentioning

confidence: 99%

“…Preparation and Characterization of MMCs : In brief, 200 mL of calcium nitrate solution (Ca(NO 3 ) 2 ·4H 2 O, 0.025 m ) consisting of 200 mg PSS, was rapidly poured into an equal volume of sodium carbonate (Na 2 CO 3 , 0.025 m ) under magnetic stirring. After standing for 20 min, the precipitated PSS‐doped CaCO 3 particles were collected and washed with deionized water.…”

Section: Methodsmentioning

confidence: 99%

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Low‐Magnetization Magnetic Microcapsules: A Synergistic Theranostic Platform for Remote Cancer Cells Therapy and Imaging

Zhang

Deng

Wang

et al. 2014

Part & Part Syst Charact

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985wileyonlinelibrary.com www.particle-journal.com www.MaterialsViews.com Multifunctional magnetic microcapsules (MMCs) for the combined cancer cells hyperthermia and chemotherapy in addition to MR imaging are successfully developed. A classical layer-by-layer technique of oppositely charged polyelectrolytes (poly(allylamine hydrochloride) (PAH) and poly(4-styrene sulfonate sodium) (PSS)) is used as it affords great controllability over the preparation together with enhanced loading of the chemotherapeutic drug (doxorubicin, DOX) in the microcapsules. Superparamagnetic iron oxide (SPIOs) nanoparticles are layered in the system to afford MMC1 (one SPIOs layer) and MMC2 (two SPIOs layers). Most interestingly, MMC1 and MMC2 show effi cient hyperthermia cell death and controlled DOX release although their magnetic saturation value falls below 2.5 emu g −1 , which is lower than the 7-22 emu g −1 reported to be the minimum value needed for biomedical applications. Moreover, MMCs are pH responsive where a pH 5.5 (often reported for cancer cells) combined with hyperthermia increases DOX release predictably. Both systems prove viable when used as T2 contrast agents for MR imaging in HeLa cells with high biocompatibility. Thus, MMCs hold a great promise to be used commercially as a theranostic platform as they are controllably prepared, reproducibly enhanced, and serve as drug delivery, hyperthermia, and MRI contrast agents at the same time.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Low‐Magnetization Magnetic Microcapsules: A Synergistic Theranostic Platform for Remote Cancer Cells Therapy and Imaging

Zhang

Deng

Wang

et al. 2014

Part & Part Syst Charact

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“…7). 119 This new technique has the advantages of time and materials saving, and can be easily scaled-up.…”

Section: Core-mediated In Situ Pe Coacervationmentioning

confidence: 99%

Layer-by-layer assembly of microcapsules and their biomedical applications

2012

Self Cite

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Nanoengineered multifunctional capsules with tailored structures and properties are of particular interest due to their multifunctions and potential applications as new colloidal structures in diverse fields. Among the available fabrication methods, the layer-by-layer (LbL) assembly of multilayer films onto colloidal particles followed by selective template removal has attracted extensive attention due to its advantages of precise control over the size, shape, composition, wall thickness and functions of the obtained capsules. The past decade has witnessed a rapid increase of research concerning the new fabrication strategies, functionalization and applications of this kind of capsules, particularly in the biomedical fields such as drug delivery, biosensors and bioreactors. In this critical review, the very recent progress of the multilayer capsules is summarized. First, the advances in assembly of capsules by the LbL technique are introduced with focus on tailoring the properties of hydrogen-bonded multilayer capsules by cross-linking, and fabrication of capsules based on covalent bonding and bio-specific interactions. Then the fabrication strategies which can speed up capsule fabrication are reviewed. In the following sections, the multi-compartmental capsules and the capsules that can transform their shape under stimulus are presented. Finally, the biomedical applications of multilayer capsules with particular emphasis on drug carriers, biosensors and bioreactors are described (306 references).

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Polyelectrolyte complexation between cationic and anionic polyelectrolytes with complementary polymer-bound reactive groups of amine and acetoacetate: effect of mono- and divalent salts

Mazumder

2014

Iran Polym J

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In Situ Coacervated Microcapsules with Filled Polyelectrolytes and Charge‐Controlled Permeation for Dye Molecules

Cited by 5 publications

References 37 publications

Low‐Magnetization Magnetic Microcapsules: A Synergistic Theranostic Platform for Remote Cancer Cells Therapy and Imaging

Low‐Magnetization Magnetic Microcapsules: A Synergistic Theranostic Platform for Remote Cancer Cells Therapy and Imaging

Layer-by-layer assembly of microcapsules and their biomedical applications

Polyelectrolyte complexation between cationic and anionic polyelectrolytes with complementary polymer-bound reactive groups of amine and acetoacetate: effect of mono- and divalent salts

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