In-situ drug generation and controllable loading: rational design of copper-based nanosystems for chemo-photothermal cancer therapy

Pan, Qingqing; Peng, Xinyu; Cun, Ju-E; Li, Junhua; Pu, Yuji; He, Bin

doi:10.1016/j.cej.2020.128222

Cited by 57 publications

(34 citation statements)

References 66 publications

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“…Simultaneously, FLIRE 60 infrared thermal imager was employed to monitor the temperature changes and capture thermal images. Photothermal stability was carried out according to our previous study [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing

Guo

Zhang

Gao

et al. 2022

Bioactive Materials

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116

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Section: Methodsmentioning

confidence: 99%

A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing

Guo

Zhang

Gao

et al. 2022

Bioactive Materials

Self Cite

116

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“…The strategy of in situ drug generation and controllable loading looks more attractive. For example, CuS and copper diethyldithiocarbamate (Cu(DTC) 2 ) were coloaded with bovine serum albumin (BSA) via a one-pot biomineralization-mimicking synthesis, forming BSD NPs, which were prepared for chemo-photothermal therapy of melanoma (Figure 8a; Pan et al, 2021). By providing Cu 2+ , S 2À , and DTC in water, the PTA of CuS and chemodrug Cu(DTC) 2 could be concurrently synthesized in situ with BSA as the biomacromolecular template.…”

Section: Combination Of Ptt With Chemotherapymentioning

confidence: 99%

Copper‐based nanomaterials for cancer theranostics

Zhong

Wang

Qian

et al. 2022

WIREs Nanomed Nanobiotechnol

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Copper‐based nanomaterials (Cu‐based NMs) with favorable biocompatibility and unique properties have attracted the attention of many biomedical researchers. Cu‐based NMs are one of the most widely studied materials in cancer treatment. In recent years, great progress has been made in the field of biomedicine, especially in the treatment and diagnosis of tumors. This review begins with the classification of Cu‐based NMs and the recent synthetic strategies of Cu‐based NMs. Then, according to the abundant and special properties of Cu‐based NMs, their application in biomedicine is summarized in detail. For biomedical imaging, such as photoacoustic imaging, positron emission tomography imaging, and multimodal imaging based on Cu‐based NMs are summarized, as well as strategies to improve the diagnostic effectiveness. Moreover, a series of unique structures and functions as well as the underlying property activity relationship of Cu‐based NMs were shown to highlight their promising therapeutic performance. Cu‐based NMs have been widely used in monotherapies, such as photothermal therapy (PTT) and chemodynamic therapy (CDT). Moreover, the sophisticated design in composition, structure, and surface fabrication of Cu‐based NMs can endow these NMs with more modalities in cancer diagnosis and therapy. To further improve the efficiency of cancer treatment, combined therapy based on Cu‐based NMs was introduced in detail. Finally, the challenges, critical factors, and future prospects for the clinical translation of Cu‐based NMs as multifunctional theranostic agents were also considered and discussed. The aim of this review is to provide a better understanding and key consideration for the rational design of this increasingly important new paradigm of Cu‐based NMs as theranostic agents. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > In Vivo Nanodiagnostics and Imaging

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“…For instance, drug tolerance and serious side effects reduce the efficiency of chemotherapy . To address these issues, chemotherapy is combined with other methods, including photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy (CDT). − Different from PTT and PDT, which are limited by insufficient light penetration depth, CDT is triggered by the endogenous H 2 O 2 of the cancer cell . CDT is a tumor-specific treatment by converting internal hydrogen peroxide to lethal ·OH through Fenton or Fenton-like reactions to devastate cancer cells .…”

Section: Introductionmentioning

confidence: 99%

Tumor Microenvironment-Activated Theranostics Nanozymes for Fluorescence Imaging and Enhanced Chemo-Chemodynamic Therapy of Tumors

Zhao

Hou

et al. 2021

ACS Appl. Mater. Interfaces

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Chemodynamic therapy (CDT) is widely explored for tumor-specific therapy by converting endogenous H 2 O 2 to lethal •OH to destroy cancer cells. However, •OH scavenging by glutathione (GSH) and insufficient intratumoral H 2 O 2 levels seriously hinder the application of CDT. Herein, we reported the fabrication of copper ion-doped ZIF-8 loaded with gold nanozymes and doxorubicin hydrochloride (DOX) for the chemotherapy and CDT synergistic treatment of tumors with the assistance of tumor microenvironment (TME)-activated fluorescence imaging. The Cu 2+ -doped ZIF-8 shell was gradually degraded to release DOX and gold nanoclusters responding to the acidic TME. The fluorescence signal of the tumor region was acquired after the quenched fluorescence of the gold nanoclusters by Cu 2+ and DOX by aggregation-induced quenching was turned on because of the interaction of GSH with Cu 2+ and the release of free DOX. The Cu 2+ ions could deplete the GSH via redox reactions and the generated Cu + could convert internal H 2 O 2 to •OH for tumor CDT. The chemotherapeutic effect of DOX was strengthened through drug efflux inhibition and drug sensitivity increase due to the consumption of GSH and •OH burst. Moreover, DOX could raise the level of H 2 O 2 and augment the effect of CDT. In addition, the fluorescent gold nanoclusters not only served as a peroxidase to convert H 2 O 2 to •OH but also employed as an oxidase to consume GSH, resulting in the amplification of chemotherapy and CDT. This work presents an approach to construct tumor microenvironment-activated theranostic probes without external stimuli and to achieve the tumor elimination through cascade reactions and synergistic treatment.

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In-situ drug generation and controllable loading: rational design of copper-based nanosystems for chemo-photothermal cancer therapy

Cited by 57 publications

References 66 publications

A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing

A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing

Copper‐based nanomaterials for cancer theranostics

Tumor Microenvironment-Activated Theranostics Nanozymes for Fluorescence Imaging and Enhanced Chemo-Chemodynamic Therapy of Tumors

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