INTRODUCTION. Currently, new biomaterials are being intensively developed to improve the efficiency of repair of damage to hard and soft tissues. New approaches and methods for functionalizing biomaterials have been proposed. One such method is the use of magnetic nanoparticles. This approach is new and still little studied, however, the annual increase in the number of publications on this topic indicates the promise of studying the osteogenic effect of magnetic nanoparticles.
AIM. To summarize the results of current research devoted to studying the effect of magnetically sensitive biomaterials on the functional activity of cells involved in the reparation of bone tissue damage.
MATERIALS AND METHODS. A literature review was conducted using the databases PubMed and Scopus. Keywords used to conduct the search: electromagnetic field, magnetic nanoparticles, biomaterials, osteoinduction, bone regeneration. Request dates: February-March 2024, publication period 2000–2024 years.
MAIN CONTENT. New approaches and methods for functionalizing biomaterials have been proposed. One such approach is the use of magnetic nanoparticles (MNPs). Traditionally, in medicine, MNPs are used as a contrast agent to improve the visualization of cancer tumors; in addition, MNPs can act as a matrix in targeted drug delivery systems and in hyperthermic therapy of cancer tumors. New experimental data show that the use of MNPs as a magnetically sensitive component in biomaterials is a promising way to stimulate the repair of bone defects and fractures. It has been shown that biomaterials modified by nanoparticles stimulate osteogenic differentiation of stem cells, increase proliferative activity and secretion of extracellular matrix proteins by bone cells.
CONCLUSION. Integration of MNPs with organic and synthetic polymers, and other biomimetic constructs is a promising direction for creating osteogenic biomaterials for medical use, including those aimed at increasing the efficiency of regeneration of bone defects. The use of magnetically sensitive biomaterials makes it possible to create “smart” tissue-engineered structures controlled by external electromagnetic stimulus.
