In situ encapsulation of rivastigmine in TAT-functionalized P(MMA-co-AA) nanoparticles through miniemulsion polymerization

Mangia, Lys H. R.; Ferraz, Helen Conceição; Souza, Raquel Santos; Pereira, Mirian Cláudia de Souza; Pinto, José Carlos

doi:10.1016/j.colsurfa.2021.126776

Cited by 6 publications

(5 citation statements)

References 62 publications

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“…It was also observed that the increase of the comonomer concentration reduced the reaction rates and the final monomer conversions for both P(MMA- co -BA) and P(MMA- co -VAc) reactions. These results are in accordance with previous literature reports that show that both VAc and BA cause the reduction of polymerization rates in MMA copolymerizations. ,, …”

Section: Resultsmentioning

confidence: 99%

“…These results are in accordance with previous literature reports that show that both VAc and BA cause the reduction of polymerization rates in MMA copolymerizations. 24,26,27 After 24 h of rest, particle aggregation could be observed, especially for higher proportions of VAc, characterizing loss of stability. When analyzing the aqueous solubilities of the monomers (20 g L −1 for vinyl acetate, 41 1.4 g L −1 for butyl acrylate, 42 and 16 g L −1 for methyl methacrylate 43 ), it might be anticipated that an increase in the concentration of the most hydrophilic monomers could impact latex stability due to monomer polymerization on the aqueous phase.…”

Section: Characterization Methods 231 Monomer Conversionmentioning

confidence: 99%

“…Polymer nanoparticles were prepared through miniemulsion polymerizations carried out as described in previous works. − The organic phase contained the MMA monomer, n -hexadecane (0.4 wt %), and, when used, PZQ (10 wt %, fully dissolved in the organic phase). For preparation of the aqueous phase, the surfactant SDS (5 wt %), the sodium bicarbonate buffer (0.4 wt %), and the KPS initiator (0.5 wt %) were dissolved in distilled water.…”

Section: Methodsmentioning

confidence: 99%

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The Influence of Glass Transition Temperature of PMMA-Based Nanoparticles on the Release Profile of Praziquantel as a Strategy for Controlling Drug Release

Hamond Regua Mangia,

Yamashita,

Guindani

et al. 2024

ACS Appl. Nano Mater.

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In the present work, nanoparticles of poly(methyl methacrylate-co-butyl acrylate) (P(MMA-co-BA)) and poly(methyl methacrylate-co-vinyl acetate) (P(MMA-co-VAc)) were synthesized by miniemulsion polymerization with the in situ encapsulation of praziquantel (PZQ) as a hydrophobic drug model. The reactions produced nanoparticles with diameters ranging from 67 ± 0.5 to 130 ± 1.1 nm, with an encapsulation efficiency of at least 99%. The glass transition temperatures (T g 's) of the produced copolymer nanoparticles were successfully reduced from 121.5 to −9.3 °C in the absence of PZQ and from 100.7 to −13.7 °C in the presence of encapsulated PZQ. In vitro release assays carried out at 37 and 50 °C showed that the rate of drug release increased with temperature, reaching maxima of 56 ± 3.7 and 38 ± 2.9% of release in 6 h for copolymers containing 40 wt % BA and 60 wt % VAc. Modeling of the available release data indicated the occurrence of an anomalous release mechanism as the driver for the drug release from the produced nanoparticles. Empirical mathematical modeling confirmed the influence of both the T g and the test temperature on the rate of drug release. Finally, experimental results strongly suggested that PZQ exerts a plasticizer effect in the system, as confirmed by DSC analyses, suggesting the existence of specific interactions between the drug and the polymer matrix. Altogether, these results point out the occurrence of multifactorial effects on release of hydrophobic drugs from nondegradable polymer particles.

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Section: Resultsmentioning

confidence: 99%

Section: Characterization Methods 231 Monomer Conversionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The Influence of Glass Transition Temperature of PMMA-Based Nanoparticles on the Release Profile of Praziquantel as a Strategy for Controlling Drug Release

Hamond Regua Mangia,

Yamashita,

Guindani

et al. 2024

ACS Appl. Nano Mater.

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“…The total test time was based on the time required for complete conversion of MMA in typical miniemulsion polymerization reactions. [39,40] Only backscattering data were used to characterize the destabilization profiles and perform quantitative analyses. The final TSI was used as a measurement of emulsion stability and was given by the equipment software, based on the evolution of the backscattering signal.…”

Section: Methodsmentioning

confidence: 99%

“…[10,17] Miniemulsion Polymerization: MMA polymerization conditions were based on a previously developed methodology. [39,40] The aqueous phase contained KPS (0.13 wt.%), sodium bicarbonate (0.10 wt.%), surfactants (Tween80 or Tween80 and SDS), and distilled water. The oil phase contained n-hexadecane (0.10 wt.%), MMA, and oily surfactant (Span80).…”

Section: Methodsmentioning

confidence: 99%

Stabilization of Aqueous MMA Emulsions Using Mixtures of Surfactants and Implications on MMA Miniemulsion Polymerizations

Mangia

Ferraz

Pinto

2022

Macro Reaction Engineering

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Miniemulsion polymerization is a robust and simple method for manufacture of polymer nanoparticles. However, it is strongly dependent on the precursor monomer-in-water emulsion stability. Thus, the present study investigates the influence of concentration and combination of nonionic surfactants (resulting in different hydrophile-lipophile balances, HLB) on the stabilization of emulsions of methyl methacrylate in water. Backscattering profiles obtained with Turbiscan show that a combination of Tween80 and Span80 can grant the desired initial system stabilization, although the optimum HLB values depend on the amount of surfactant mixture. Miniemulsion polymerizations are then successfully performed with nonionic surfactant mixtures, providing high monomer conversion in less than 1 h and poly(methyl methacrylate) nanoparticles with average diameters ranging from 300 to 500 nm. Finally, it is observed that the addition of small amounts of an anionic surfactant to the surfactant mixture (10 wt.%) can be very beneficial for the process, allowing the control of reaction rates, the production of smaller nanoparticles with average diameters from 100 to 300 nm, and the enhanced stabilization of the final solid dispersion, while simultaneously keeping the concentration of ionic surfactants small.

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Acrylic polymer nanoparticles: cytotoxicity, cell permeability, and biodistribution in mice after intravenous injection

Mattos

Campos²,

Marques³

et al. 2023

J Nanopart Res

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In situ encapsulation of rivastigmine in TAT-functionalized P(MMA-co-AA) nanoparticles through miniemulsion polymerization

Cited by 6 publications

References 62 publications

The Influence of Glass Transition Temperature of PMMA-Based Nanoparticles on the Release Profile of Praziquantel as a Strategy for Controlling Drug Release

The Influence of Glass Transition Temperature of PMMA-Based Nanoparticles on the Release Profile of Praziquantel as a Strategy for Controlling Drug Release

Stabilization of Aqueous MMA Emulsions Using Mixtures of Surfactants and Implications on MMA Miniemulsion Polymerizations

Acrylic polymer nanoparticles: cytotoxicity, cell permeability, and biodistribution in mice after intravenous injection

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