In Situ Fabrication of Silver Peroxide Hybrid Ultrathin Co-Based Metal–Organic Frameworks for Enhanced Chemodynamic Antibacterial Therapy

Abstract

Bacterial-induced infectious diseases have always caused an unavoidable problem and lead to an increasing threat to human health. Hence, there is an urgent need for effective antibacterial strategies to treat infectious diseases. Current methods are often ineffective and require large amounts of hydrogen peroxide (H2O2), with harmful effects on normal healthy tissue. Chemodynamic therapy (CDT) provides an ideal infection microenvironment (IME)-activated paradigm to tackle bacterial-related diseases. To take full advantage of the specificity of IME and enhanced CDT for wounds with bacterial infection, we have designed an intelligent antibacterial system that exploits nanocatalytic ZIF-67@Ag2O2 nanosheets. In this system, silver peroxide nanoparticles (Ag2O2 NPs) were grown on ultrathin zeolitic imidazolate framework-67 (ZIF-67) nanosheets by in situ oxidation, and then, ZIF-67@Ag2O2 nanosheets with the ability to self-generate H2O2 were triggered by the mildly acidic environment of IME. Lamellar ZIF-67 nanosheets were shown to rapidly degrade and release Co2+, allowing the conversion of less reactive H2O2 into the highly toxic reactive oxygen species hydroxyl radicals (•OH) for enhanced CDT antibacterial properties. In vivo results revealed that the ZIF-67@Ag2O2 nanosheet system exhibits excellent antibacterial performance against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The proposed hybrid strategy demonstrates a promising therapeutic strategy to enable antibacterial agents with IME-responsive nanocatalytic activity to circumvent antibiotic resistance against bacterial infections.

Intracellular infection-responsive macrophage-targeted nanoparticles for synergistic antibiotic immunotherapy of bacterial infection

“…S. aureus is an opportunistic pathogen and causes approximately 80–90% of all skin and soft tissue infections. 52 Van is the preferable choice for eradication of S. aureus . However, Van may have serious adverse effects, including kidney damage, thrombophlebitis, Red Man syndrome, and epidermal necrolysis, possibly leading to toxic symptoms that are worse than the infection.…”

CuS/Co-Ferrocene-MOF Nanocomposites for Photothermally Enhanced Chemodynamic Antibacterial Therapy

“…Bacterial infection has become a serious threat to public health. − Antibiotics have long been the most effective drugs against bacterial infections, but the overuse of antibiotics has led to an increased rate of illness and increased microbial resistance to antibiotics. − Therefore, the development of emerging functional nanomaterials or antibacterial technologies with antidrug-resistant and anti-infective properties will help protect wounds and treat drug-resistant bacterial infections. − Chemodynamic therapy (CDT) is a promising antibacterial therapy that harnesses Fenton or Fenton-like reactions catalyzed by nanomaterials to generate hydroxyl radical (·OH) from H 2 O 2 in the infected microenvironment to induce bacterial death. − The advancement of potent Fenton or Fenton-like reagents is crucial for achieving effective CDT, making it a central focus in the field of nanomedicine. In the past decade, there have been several promising Fenton or Fenton-like reagents introduced and developed for CDT, such as noble metal-based nanomaterials, , metal oxide-based nanomaterials, − carbon-based nanomaterials, − and metal–organic frameworks (MOF)-based nanomaterials. − Among them, the porous nano-MOF have been extensively studied in biomedical fields recently due to their low toxicity and good biocompatibility. − However, they usually display limited or insignificant Fenton-like catalytic activity, which hinders their effectiveness for CDT.…”

Engineering H2O2 Self-Supplying Platform for Xdynamic Therapies via Ru–Cu Peroxide Nanocarrier: Tumor Microenvironment-Mediated Synergistic Therapy

“…In this context, the capacity of MO 2 to generate H 2 O 2 introduces the potential for developing cascade Fenton nanoagents for catalytic nanotherapeutics. MO 2 generally comprises metal ions and peroxo groups, which can undergo a reaction with H 2 O resulting in the formation of H 2 O 2 . − The H 2 O 2 produced in this process has various valuable applications in the field of biomedicine. , This self-generated H 2 O 2 can serve as a reactant in Fenton (like) catalytic reactions, leading to the production of a large number of •OH for cancer nanomedicine. ,, Additionally, H 2 O 2 can self-decay to generate O 2 , enhancing the therapeutic effectiveness of different O 2 -dependent modalities such as PDT and RT. , …”

“…MO 2 generally comprises metal ions and peroxo groups, which can undergo a reaction with H 2 O resulting in the formation of H 2 O 2 . 30 − 32 The H 2 O 2 produced in this process has various valuable applications in the field of biomedicine. 33 , 34 This self-generated H 2 O 2 can serve as a reactant in Fenton (like) catalytic reactions, leading to the production of a large number of •OH for cancer nanomedicine.…”