In Situ Fiber-Optic Dissolution Assisted by a Mathematical Separation Model of Dynamic Three-Wavelength K-Ratio Spectrophotometry

Abstract

The aim of this study was to monitor the drug release of ibuprofen sustained-release capsules in real time in situ. A mathematical separation model of dynamic three-wavelength K-ratio spectrophotometry was established to eliminate the interference of gelatin capsule shells when drug release was monitored by a fiber-optic drug dissolution in situ test system. A control experiment with high performance liquid chromatography was performed simultaneously. Within 7 h, real-time drug release profiles were obtained. The average drug release rates were 19.79%, 37.34%, 63.13%, and 88.41% by the fiber-optic drug dissolution in situ test system at the respective time points of 1 h, 2 h, 4 h, and 7 h. There were no significant differences between the in situ and control methods. Drug release of ibuprofen sustained-release capsules can be monitored by the fiber-optic drug dissolution in situ test system assisted by the mathematical separation model of dynamic three-wavelength K-ratio spectrophotometry. Information about the entire dissolution process can be produced by the real-time release profile.

Influence of Particle Size on the Ultraviolet Spectrum of Particulate-Containing Solutions: Implications for In-Situ Concentration Monitoring Using UV/Vis Fiber-Optic Probes

“…For example, when using a combination of filtration and HPLC separation for quantification, interference from absorption of dissolved excipients typically can be prevented. This is not always the case when using fiber-optic probes (27); however, successful examples exist where solution drug concentrations were accurately measured in the presence of interfering dissolved species through the use of multivariate chemometric methods (28) or three-wavelength K-ratio spectrophotometry (29). Two other important sources of interference that can impact the analysis when filtration is not performed prior to measurement are insoluble excipient particles as well as particles arising from the drug itself.…”

In Situ Liquid-Phase-Adsorption Measurement System Based on Fiber-Optic Sensing with the Aid of Membranes

“…Fiber-optic sensing (FOS) technology has become more mature and popular because of acceptable costs, compact instrumentation, high accuracy, and the capability of performing measurements in situ and real time, after over 30 years of innovation . As is well known, fiber-optics enable direct measurement of optical spectroscopy, from the infrared to the ultraviolet, in absorption, emission, and plasmonic resonance, to be performed at inaccessible sites, over large distances, in strong magnetic fields, and in harsh environments. , Among the spectroscopy, the FOS based on UV–vis absorption has gained the most wide application owing to its low cost, simplicity, and high precision, typically in drug dissolution testing. ,− For the first time, Josefson reported a dissolution testing method, using felodipine tablet as an example, by means of optical fiber absorption spectrophotometer in turbid solution . Using this method, it is enabled to achieve in situ, real-time, and complete process measurement of tablet dissolution.…”

Rapid analysis of piperazine ferulate tablets by optic-fiber sensing technology and the similarity of ultraviolet spectra

“…Nevertheless, these methods need development and improvement [1] . Over the past years, we have been studying the application of optic-fiber sensing technology to drug detection [2] , [3] . Optical-fiber is suitable for spot analysis and rapid drug test because of its special characteristics of being small, flexible and portable as well as low transmission loss [4] , [5] , [6] .…”