In-situ food spoilage monitoring using a wireless chemical receptor-conjugated graphene electronic nose

Kim, Kyung Ho; Park, Chul Soon; Park, Seon Joo; Kim, Jin-Yeong; Seo, Sung Eun; An, Jai Eun; Ha, Siyoung; Bae, Joonwon; Phyo, Sooyeol; Lee, Jiwon; Kim, Kayoung; Moon, Dongseok; Park, Tai Hyun; Song, Hyun Seok; Kwon, Oh Seok

doi:10.1016/j.bios.2021.113908

Cited by 42 publications

(27 citation statements)

References 60 publications

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“…Responses were collected from the Keithley 2612A source meter connected to the probe station (MS-TECH, model 4000A). Constant voltages for the drain/source and gate were applied during real-time monitoring ( V ds = 10 mV and V g = 0.1 V). − To construct a liquid phase transistor, a chamber containing 40 μL of pH 7.4 PBS solution was set up on the transistor. Each vanilloid solution was serially diluted from freshly prepared 1 mM stock solution and applied to the chamber.…”

Section: Experimental Methodsmentioning

confidence: 99%

Highly Efficient Real-Time TRPV1 Screening Methodology for Effective Drug Candidates

Lim

Seo

et al. 2022

ACS Omega

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Transient receptor potential vanilloid 1 (TRPV1) agonists that bind to the vanilloid pocket are being actively studied in the pharmaceutical industry to develop novel treatments for chronic pain and cancer. To discover synthetic vanilloids without the side effect of capsaicin, a time-consuming process of drug candidate selection is essential to a myriad of chemical compounds. Herein, we propose a novel approach to field-effect transistors for the fast and facile screening of lead vanilloid compounds for the development of TRPV1-targeting medications. The graphene field-effect transistor was fabricated with human TRPV1 receptor protein as the bioprobe, and various analyses (SEM, Raman, and FT-IR) were utilized to verify successful manufacture. Simulations of TRPV1 with capsaicin, olvanil, and arvanil were conducted using AutoDock Vina/PyMOL to confirm the binding affinity. The interaction of the ligands with TRPV1 was detected via the fabricated platform, and the collected responses corresponded to the simulation analysis.

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Section: Experimental Methodsmentioning

confidence: 99%

Highly Efficient Real-Time TRPV1 Screening Methodology for Effective Drug Candidates

Lim

Seo

et al. 2022

ACS Omega

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“…An ultrahigh-performance supercritical fluid chromatography (UHPSFC) method was utilized for polyamine detection in gentamicin sulfate [ 101 ]. The in-situ high-performance chemical receptor-conjugated graphene electronic nose shows potential applications for polyamine detection [ 102 ]. Overall, more robust constitution techniques need to be developed to meet the requirements of polyamine determination.…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Recent Advances in Fluorescent Methods for Polyamine Detection and the Polyamine Suppressing Strategy in Tumor Treatment

Wang

Ran

et al. 2022

Biosensors

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The biogenic aliphatic polyamines (spermine, spermidine, and putrescine) are responsible for numerous cell functions, including cell proliferation, the stabilization of nucleic acid conformations, cell division, homeostasis, gene expression, and protein synthesis in living organisms. The change of polyamine concentrations in the urine or blood is usually related to the presence of malignant tumors and is regarded as a biomarker for the early diagnosis of cancer. Therefore, the detection of polyamine levels in physiological fluids can provide valuable information in terms of cancer diagnosis and in monitoring therapeutic effects. In this review, we summarize the recent advances in fluorescent methods for polyamine detection (supramolecular fluorescent sensing systems, fluorescent probes based on the chromophore reaction, fluorescent small molecules, and fluorescent nanoparticles). In addition, tumor polyamine-suppressing strategies (such as polyamine conjugate, polyamine analogs, combinations that target multiple components, spermine-responsive supramolecular chemotherapy, a combination of polyamine consumption and photodynamic therapy, etc.) are highlighted. We hope that this review promotes the development of more efficient polyamine detection methods and provides a comprehensive understanding of polyamine-based tumor suppressor strategies.

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“…Monolayer graphene (MLG) was synthesized using a chemical vapor deposition (CVD) method based on our previous reports [12][13][14][15]. Graphene film was formed on the copper foil substrate and was synthesized from the gas sources CH 4 , H 2 , and Ar at 1,000 ∘ C. Then, the MLG surface was coated with PMMA for protection.…”

Section: Fabrication Of Monolayer Graphenementioning

confidence: 99%

“…MLG has various properties, such as a zero bandgap, high carrier mobility, high conductivity, ambipolar properties, and rapid electron transport [14,[18][19][20]. MLG has been utilized in various applications and has been applied in preparing bio/chemosensors owing to its excellent electrical properties [21,22].…”

Section: Characterization Of Sab-conjugated Mlgmentioning

confidence: 99%

A Portable Graphene Micropatterned Field-Effect Transistor Device for Rapid Real-Time Monitoring of Serotonin

Kim

Seo

Kwon

2022

Appl. Sci. Converg. Technol.

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Serotonin is a stress biomarker and is one of the major neurotransmitters, and its concentration in the body is related to psychological functions such as mental illness. In particular, this biomarker is used to indicate depression caused by the increased stress of modern society. Therefore, detection and monitoring technologies are important for tracing concentration changes. In this study, we developed a serotonin antibodyconjugated graphene micropatterned field-effect transistor (SAb-GMFET)-based portable device for on-site or self-diagnosis of serotonin. The SAb-GMFET consisted of a graphene micropatterned channel, SAb for selective detection, and electrodes to supply the voltage. The SAb was immobilized by forming an amide bond with a diamine linker. SAb-GFMET showed high performance of limit of detection of 10 pM within 10 s and exhibited excellent selective detection among the interfering materials. For on-site and self-diagnosis applications, a portable device was developed with a sim chip, and the SAb-GMFET was connected to a printed circuit board using wire bonding. The portable SAb-GMFET showed a similar performance to that of the SAb-GMFET. Therefore, this portable platform can be utilized for point-of-care tests.

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In-situ food spoilage monitoring using a wireless chemical receptor-conjugated graphene electronic nose

Cited by 42 publications

References 60 publications

Highly Efficient Real-Time TRPV1 Screening Methodology for Effective Drug Candidates

Highly Efficient Real-Time TRPV1 Screening Methodology for Effective Drug Candidates

Recent Advances in Fluorescent Methods for Polyamine Detection and the Polyamine Suppressing Strategy in Tumor Treatment

A Portable Graphene Micropatterned Field-Effect Transistor Device for Rapid Real-Time Monitoring of Serotonin

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