In Situ Formation of Covalent Second Network in a DNA Supramolecular Hydrogel and Its Application for 3D Cell Imaging

Cao, Tianyang; Jia, Haoyang; Dong, Yuanchen; Gui, Songbai

doi:10.1021/acsami.9b11534

Cited by 52 publications

(38 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[229] In recent years, DNA hydrogels have developed very rapidly, and many research reports have emerged. [228,[230][231][232][233][234][235][236][237] The use of the DNA hybridization reaction to prepare crosslinked hydrogel structures also needs to overcome a critical challenge to substantially increase the degree of swelling. The swelling rate of the DNA hydrogel hybridization reaction is generally reported to be only 10%-15%, which is not enough to achieve macroscopic material deformation.…”

Section: Molecular Specific Bindingmentioning

confidence: 99%

Hydrogel: Diversity of Structures and Applications in Food Science

Jia

Luo

2021

Food Reviews International

117

View full text Add to dashboard Cite

Hydrogels are a series of soft and wet materials with three dimensions of crosslinked networks. Hydrogels have attracted great attention due to their diverse functional properties, and their wide range of applications, such as in soft robots and actuators, stretched electronic devices, tissue engineering materials, controlled-release drug delivery vehicles, biomedicine materials, food science, and (bio)sensors. In general, there are four core concerns in hydrogel science, including the polymer source, structure fabrication, gel function, and gel applications. According to the logic that the "structure determines function", it is believed that rational design of structures can effectively regulate the functions and applications of hydrogels. Hence, in the current review, "structure" as the core topic will be highly regarded, and the crosslinking mechanisms and structural diversity of hydrogels are comprehensively summarized. Additionally, hydrogels also show their great application potential in food science. Hence, the current review also pays more attention to the application of hydrogels in food nutrition and health, food engineering and processing, and food safety. It is whished that this review not only serves as a reference for improving the comprehensive understanding of the structural design of hydrogels but also provides a forward-looking idea for hydrogel applications in food science.

show abstract

Section: Molecular Specific Bindingmentioning

confidence: 99%

Hydrogel: Diversity of Structures and Applications in Food Science

Jia

Luo

2021

Food Reviews International

117

View full text Add to dashboard Cite

show abstract

“…Reproduced with permission. [206] Copyright 2020, American Chemical Society. immobilization of the cells inside the hydrogel, this strategy is suitable for immunostaining and cell imaging (Figure 9D).…”

Section: Bioimagingmentioning

confidence: 99%

mentioning

confidence: 99%

Smart and Functionalized Development of Nucleic Acid‐Based Hydrogels: Assembly Strategies, Recent Advances, and Challenges

et al. 2021

View full text Add to dashboard Cite

Nucleic acid-based hydrogels that integrate intrinsic biological properties of nucleic acids and mechanical behavior of their advanced assemblies are appealing bioanalysis and biomedical studies for the development of new-generation smart biomaterials. It is inseparable from development and incorporation of novel structural and functional units. This review highlights different functional units of nucleic acids, polymers, and novel nanomaterials in the order of structures, properties, and functions, and their assembly strategies for the fabrication of nucleic acid-based hydrogels. Also, recent advances in the design of multifunctional and stimuli-responsive nucleic acid-based hydrogels in bioanalysis and biomedical science are discussed, focusing on the applications of customized hydrogels for emerging directions, including 3D cell cultivation and 3D bioprinting. Finally, the key challenge and future perspectives are outlined.

show abstract

“…[41] This might be ascribed to the rigidity of DX that makes the hydrogel network more rigid, thus improving the mechanical strength of the hydrogel. [45][46][47] Then we characterized the shear thinning property of the DX hydrogel under strain-scan mode. As shown in Figure 3b, with the increase of shear strain, G′ of the hydrogel decreased rapidly and G″ increased slowly.…”

Section: Rheological Studies On Dna Supramolecular Hydrogelsmentioning

confidence: 99%

Kinetically Interlocking Multiple‐Units Polymerization of DNA Double Crossover and Its Application in Hydrogel Formation

Shi

Zhu

et al. 2021

Macromol. Rapid Commun.

Self Cite

View full text Add to dashboard Cite

A novel kinetically interlocking multiple-units (KIMU) supramolecular polymerization system with DNA double crossover backbone is designed. The rigidity of DX endows the polymer with high molecular weight and stability. The observed concentration of the formed polymers is insensitive and stable under ultralow monomer concentration owing to the KIMU interactions, in which multiple noncovalent interactions are connected by the phosphodiester bonds. Furthermore, a pH-responsive DNA supramolecular hydrogel is constructed by introducing a half i-motif domain into the DNA monomer. The rigidity of DNA polymer endows the hydrogel with high mechanical strength and low gelation concentration. This study enriches the KIMU strategy and offers a simple but effective way to fabricate long and stable supramolecular polymers by balancing the reversibility and stability. It also shows great potentials to construct next generation of smart materials, such as DNA nanostructures, DNA motors, and DNA hydrogels.

show abstract

In Situ Formation of Covalent Second Network in a DNA Supramolecular Hydrogel and Its Application for 3D Cell Imaging

Cited by 52 publications

References 47 publications

Hydrogel: Diversity of Structures and Applications in Food Science

Hydrogel: Diversity of Structures and Applications in Food Science

Smart and Functionalized Development of Nucleic Acid‐Based Hydrogels: Assembly Strategies, Recent Advances, and Challenges

Kinetically Interlocking Multiple‐Units Polymerization of DNA Double Crossover and Its Application in Hydrogel Formation

Contact Info

Product

Resources

About