In situ formation of poly (thiolated chitosan-co-alkylated β-cyclodextrin) hydrogels using click cross-linking for sustained drug release

Yang, Ning; Wang, Yue; Zhang, Qingsong; Chen, Li; Zhao, Yiping

doi:10.1007/s10853-018-2910-3

Cited by 24 publications

(9 citation statements)

References 46 publications

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“…The observed G′ values remained constant for most part of the measurements, in agreement with the expected behaviour in covalently crosslinked hydrogel networks. 59,60 Moreover, the obtained G′ values remained similar to other hydrogel systems formed by PEG-derivatives with the same type of crosslinking with G′ values around 1349 ± 345 Pa for 10% PEG-TZ and 2978 ± 217 Pa for 20% PEG-TZ. 61,62 Time sweep measurements (Fig.…”

Section: Rheological Studiessupporting

confidence: 76%

Fabrication of hydrogel microspheres via microfluidics using inverse electron demand Diels–Alder click chemistry-based tetrazine-norbornene for drug delivery and cell encapsulation applications

et al. 2023

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Section: Rheological Studiessupporting

confidence: 76%

Fabrication of hydrogel microspheres via microfluidics using inverse electron demand Diels–Alder click chemistry-based tetrazine-norbornene for drug delivery and cell encapsulation applications

et al. 2023

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“… 135 The gelling characteristics of such systems can be altered by the concentration of available thiol groups on chitosan and by the type of reaction partner. 72 , 136 , 137 …”

Section: Properties Of Thiolated Chitosansmentioning

confidence: 99%

“…In addition to the mentioned gelling process via oxidation, thiol–ene reactions between thiolated chitosans and alkenes can be utilized to generate in situ gelling systems . The gelling characteristics of such systems can be altered by the concentration of available thiol groups on chitosan and by the type of reaction partner. ,, …”

Section: Properties Of Thiolated Chitosansmentioning

confidence: 99%

Thiolated Chitosans: A Multi-talented Class of Polymers for Various Applications

2020

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Various properties of chitosan can be customized by thiolation for very specific needs in a wide range of application areas. Since the discovery of thiolated chitosans, many studies have proven their advantageous characteristics, such as adhesion to biological surfaces, adjustable cross-linking and swelling behavior, controllable drug release, permeation as well as cellular uptake enhancement, inhibition of efflux pumps and enzymes, complexation of metal ions, antioxidative properties, and radical scavenging activity. Simultaneously, these polymers remain biodegradable without increased toxicity. Within this Review, an overview about the different possibilities to covalently attach sulfhydryl ligands to the polymeric backbone of chitosan is given, and the resulting versatile physiochemical properties are discussed in detail. Furthermore, the broad spectrum of applications for thiolated chitosans in science and industry, ranging from their most advanced use in pharmaceutical and medical science over wastewater treatment to the impregnation of textiles, is addressed.

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“…Chitosan (CS) is the N-deacetylated product of chitin, and the –OH and –NH 2 containing in the molecule can form a chelate with metal ions (Figure 1a) [3], which is widely used in metal ions adsorption [4,5,6], organic adsorption [7,8] and other water treatment fields. In addition, CS possess good membrane formation, excellent biocompatibility and hydrophilicity making it widely used in the membrane separation process [9,10,11]. Rodrigo et al [12] prepared CS membranes by glutaraldehyde crosslinked to adsorb Hg 2+ , and the maximum amount of adsorption was 75.7 mg/g at pH 6.…”

Section: Introductionmentioning

confidence: 99%

Study on Preparation and Separation and Adsorption Performance of Knitted Tube Composite β-Cyclodextrin/Chitosan Porous Membrane

Tang

et al. 2019

Polymers

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In order to obtain membranes with both organic separation and adsorption functions, knitted tube composite β-cyclodextrin/chitosan (β-CD/CS) porous membranes were prepared by the non-solvent induced phase separation (NIPS) method using CS and β-CD as a membrane-forming matrix, glutaraldehyde as crosslinking agent to improve water stability, and knitted tube as reinforcement to enhance the mechanical properties. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), contact angle, water flux, bovine serum albumin (BSA) rejection and tensile test were carried out. The FTIR demonstrated that the β-CD and CS had been successfully crosslinked. With the crosslinking time increased, the membrane structure became denser, the contact angle and the rejection rate increased, while the water flux decreased. The strength and elongation at a break were 236 and 1.7 times higher than these of bare β-CD/CS porous membranes, respectively. The strength of crosslinking membranes increased further. The adsorption performance of composite membranes was investigated for the removal of phenolphthalein (PP) from aqueous solution. The adsorption process followed the Langmuir isotherm model, and the kinetic behavior was accorded with the Double constant equation and the Elovich equation. The adsorption mechanism could be explained by the synergistic effect of host-guest interaction from β-cyclodextrin, non-uniform diffusion and porous network capture.

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In situ formation of poly (thiolated chitosan-co-alkylated β-cyclodextrin) hydrogels using click cross-linking for sustained drug release

Cited by 24 publications

References 46 publications

Fabrication of hydrogel microspheres via microfluidics using inverse electron demand Diels–Alder click chemistry-based tetrazine-norbornene for drug delivery and cell encapsulation applications

Fabrication of hydrogel microspheres via microfluidics using inverse electron demand Diels–Alder click chemistry-based tetrazine-norbornene for drug delivery and cell encapsulation applications

Thiolated Chitosans: A Multi-talented Class of Polymers for Various Applications

Study on Preparation and Separation and Adsorption Performance of Knitted Tube Composite β-Cyclodextrin/Chitosan Porous Membrane

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