In situ formation of thymol-based hydrophobic deep eutectic solvents: Application to antibiotics analysis in surface water based on liquid-liquid microextraction followed by liquid chromatography

Li, Ke; Jin, Yan; Jung, Dasom; Park, Keun-Bae; Kim, Hireem; Lee, Jeongmi

doi:10.1016/j.chroma.2019.460730

Cited by 85 publications

(33 citation statements)

References 29 publications

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“…Typically, DESs are synthesized by mixing two pure chemicals, in which one compound acting as a donor (HBD), and the other acting as a hydrogen bond acceptor (HBA) [38,39]. In these studies, a less frequently used in-situ method was applied [40]. Only one component (HBA or HBD) was added to a solution that contains DES precursors.…”

Section: Biorefining-des Separationmentioning

confidence: 99%

Management of Dark Fermentation Broth via Bio Refining and Photo Fermentation

et al. 2021

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Lignocellulose and starch-based raw materials are often applied in the investigations regarding biohydrogen generation using dark fermentation. Management of the arising post-fermentation broth becomes a problem. The Authors proposed sequential processes, to improve the efficiency of both hydrogen generation and by-products management carried under model conditions. During the proposed procedure, the simple sugars remaining in broth are converted into organic acids, and when these products are used as substrates for the photo fermentation process. To enhance the broth management also conditions promoting Deep Eutectic Solvents (DES) precursors synthesis are simultaneously applied. Application of Box-Behnken design allows defining of the optimal conditions for conversion to DESs precursors. During the procedure hydrogen was obtained, the concentration of hydrogen in the photo fermentation reached up to 819 mL H2/L medium/7 d, depending on the broth type, i.e., when the broth was optimized for formic acid concentration. The DESs precursors were separated and engaged in DESs synthesis. To confirm the formation of the DESs, FT-IR analyses were performed. The Chemical Oxygen Demand of post-fermentation broths after dark fermentation optimized for formic acid was reduced by ca. 82%. The proposed procedure can be successfully used as a method of post-fermentation broth management.

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Section: Biorefining-des Separationmentioning

confidence: 99%

Management of Dark Fermentation Broth via Bio Refining and Photo Fermentation

et al. 2021

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“…The unique features of DESs have boosted their applications in analytical chemistry, especially as alternative extraction solvents in sample preparation. In this sense, as can be seen in Table 1 [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25], these solvents have been successfully employed for the evaluation of plastic migrants [11,16], pharmaceuticals [12,13,17,19], pesticides [14,15,18,25], dyes [15], hormones [16], ultraviolet (UV)-filters [16,21], polycyclic aromatic hydrocarbons (PAHs) [22] and explosives [24] in different environmental matrices, mainly water samples [11][12][13][14][15][16][17][18][19]21,22,24,25] and to a lesser extent in soil samples [15,24]. Among the types of DESs used with this purpose, HDESs have signif...…”

Section: Analysis Of Organic Compounds In Environmental Samplesmentioning

confidence: 70%

“…In addition, ChCl-based DESs have also been applied to capture CO 2 from natural gas [20] and biomass delignification [23]. Regarding the extraction procedures, the application of DESs has taken place in various microextraction techniques including liquid-liquid microextraction (LLME) [11,13,[15][16][17][18]21,22] and its dispersive mode (DLLME) [12,14,19], assisted by vortex (VA) [11,15,19], ultrasounds (UA) [14,18,22], air cycles of pulling in/pushing out [16,21], using a mechanical shaker (SA) [17], controlled by pH changes [13] and solidifying the floating organic droplet (SFOD) after the extraction process [16,22], as well as in solid-phase extraction in its magneticmicro-dispersive mode (m-µ-dSPE) [24,25]. A heating and stirring extraction has also been developed [23].…”

Section: Analysis Of Organic Compounds In Environmental Samplesmentioning

confidence: 99%

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Recent Applications of Deep Eutectic Solvents in Environmental Analysis

et al. 2021

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The incessant generation of toxic waste and the growing concern over the environment have led the scientific community to delve into the search for more sustainable systems. In this regard, the application of deep eutectic solvents (DESs) has become one of the main strategies in green chemistry. These solvents have emerged as a promising alternative to conventional toxic solvents and even to the well-known ionic liquids. Their unique properties, components availability, and easy preparation, among others, have led to a new trend within the scientific community and industry, based on the use of these up-and-coming solvents not only in science but also in quotidian life. Among the areas that have benefited from the advantages of DESs is analytical chemistry, in which they have been largely used for sample preparation, including the extraction and determination of organic and inorganic compounds from environmental samples. The considerable number of applications developed in the last year in this field and the increasing generation of new data necessitate the continuous updating of the literature. This review pretends to compile the most relevant applications of DESs in environmental analysis and critically discuss them to provide a global vision about the advantages and drawbacks/limitations of these neoteric solvents in the area of environmental analysis.

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“…In particular, they used a centrifuge tube, where 10 mL of aqueous sample solution were mixed with the individual DES components (67.5 mg of thymol and 31.9 µL of heptanoic acid), which formed thymol-fatty acid HDES as a water-immiscible liquid droplet after shaking and incubation at 52 • C. After the in situ formation, the tube was automated vortexed for 1 min, centrifuged for 2 min and the final DES enriched phase was diluted in the mobile phase for injection. The method provided a limit of detection of 3.0 ng/mL, and allowed the determination of FQs through a simple and fast protocol, which requires about 8 min, without additional time consumption for the synthesis of DES [125].…”

Section: Dispersive Liquid-liquid Microextraction (Dllme)mentioning

confidence: 99%

Microextraction Techniques with Deep Eutectic Solvents

2020

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In this review, the ever-increasing use of deep eutectic solvents (DES) in microextraction techniques will be discussed, focusing on the reasons needed to replace conventional extraction techniques with greener approaches that follow the principles of green analytical chemistry. The properties of DES will be discussed, pinpointing their exceptional performance and analytical parameters, justifying their current extensive scientific interest. Finally, a variety of applications for commonly used microextraction techniques will be reported.

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In situ formation of thymol-based hydrophobic deep eutectic solvents: Application to antibiotics analysis in surface water based on liquid-liquid microextraction followed by liquid chromatography

Cited by 85 publications

References 29 publications

Management of Dark Fermentation Broth via Bio Refining and Photo Fermentation

Management of Dark Fermentation Broth via Bio Refining and Photo Fermentation

Recent Applications of Deep Eutectic Solvents in Environmental Analysis

Microextraction Techniques with Deep Eutectic Solvents

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