In situ-formed micro silk fibroin composite sutures for pain management and anti-infection

Li, Xiaoxiao; Luo, Ying; Yang, Fengbo; Chu, Guoping; Li, Lingqiao; Diao, Liyang; Jia, Xiaoli; Yu, Chunjing; Wu, Xiaozhuo; Zhong, Wen; Xing, Malcolm; Lyu, Guozhong

doi:10.1016/j.compositesb.2023.110729

Cited by 8 publications

(2 citation statements)

References 53 publications

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“…The pain-relieving drug ibuprofen was loaded in this suture, and its pain-modulating effect has been verified. 102 The presence of ibuprofen in the suture helped to get through the post-surgical inflammatory period and allowed the patient to move more smoothly into a comfortable recovery.…”

Section: Applicationsmentioning

confidence: 99%

Silk-based intelligent fibers and textiles: structures, properties, and applications

Yang,

Wang,

Wang

et al. 2024

Chem. Commun.

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Section: Applicationsmentioning

confidence: 99%

Silk-based intelligent fibers and textiles: structures, properties, and applications

Yang,

Wang,

Wang

et al. 2024

Chem. Commun.

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“…Natural polymers usually show weak mechanical properties, poorly controlled chemical and physical properties, and fast degradation rates [ 21 , 29 ]. Natural hydrogels can be chemically modified to cross-linkable methacrylate(MA), such as alginate (MAA) [ 30 ] and methacryloyl gelatine (GelMA) [ 31 , 32 ]. Synthetic polymers have high reproducibility in synthesis and biological experiments [ 20 , 33 ], such as cell cultures, with stable results [ 21 ].…”

Section: Manufacture Of Ocsmentioning

confidence: 99%

Development of Organs-on-Chips and Their Impact on Precision Medicine and Advanced System Simulation

Luo

Zhao

et al. 2023

Pharmaceutics

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Drugs may undergo costly preclinical studies but still fail to demonstrate their efficacy in clinical trials, which makes it challenging to discover new drugs. Both in vitro and in vivo models are essential for disease research and therapeutic development. However, these models cannot simulate the physiological and pathological environment in the human body, resulting in limited drug detection and inaccurate disease modelling, failing to provide valid guidance for clinical application. Organs-on-chips (OCs) are devices that serve as a micro-physiological system or a tissue-on-a-chip; they provide accurate insights into certain functions and the pathophysiology of organs to precisely predict the safety and efficiency of drugs in the body. OCs are faster, more economical, and more precise. Thus, they are projected to become a crucial addition to, and a long-term replacement for, traditional preclinical cell cultures, animal studies, and even human clinical trials. This paper first outlines the nature of OCs and their significance, and then details their manufacturing-related materials and methodology. It also discusses applications of OCs in drug screening and disease modelling and treatment, and presents the future perspective of OCs.

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Multifunctional Analgesic Sutures from Microfluidic Spinning Technology

Peng,

Shang,

Che

et al. 2024

Adv Healthcare Materials

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Sutures are the most commonly used wound repair method after surgery. However, addressing delayed recovery and pain management remains a significant challenge. Here, microfibers are developed from microfluidic spinning with long‐lasting analgesia capabilities for sutures. By using a solvent extraction manner, the polycaprolactone (PCL) microfibers encapsulated with ropivacaine (ROP), a well‐known analgesic, can be continuously obtained from microfluidics. The intrinsic property of PCL and the advantage of microfluidic spinning technique impart the microfiber with highly controlled morphologies, mechanical strengths, as well as drug release. After exploring their biocompatibility both at in vitro and in vivo levels, the microfibers are directly applied to wound suture. The results demonstrate the lasting analgesic effect of the microfiber on mice with incision pain, highlighting its potential as promising suture for post‐surgery treatments. It is anticipated that the multifunctional analgesic sutures produced through microfluidic spinning will pave the way for utilizing fibers as effective sutures in clinical incision wound treatment.

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In situ-formed micro silk fibroin composite sutures for pain management and anti-infection

Cited by 8 publications

References 53 publications

Silk-based intelligent fibers and textiles: structures, properties, and applications

Silk-based intelligent fibers and textiles: structures, properties, and applications

Development of Organs-on-Chips and Their Impact on Precision Medicine and Advanced System Simulation

Multifunctional Analgesic Sutures from Microfluidic Spinning Technology

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