In situ forming and reactive oxygen species-scavenging gelatin hydrogels for enhancing wound healing efficacy

Thi, Phuong Le; Lee, Yunki; Tran, Dieu Linh; Thi, Thai Thanh Hoang; Kang, Jeon Il; Park, Kyung Min; Парк, Ки Донг

doi:10.1016/j.actbio.2019.12.009

Cited by 200 publications

(137 citation statements)

References 44 publications

Supporting

Mentioning

136

Contrasting

Order By: Relevance

“…Further, GH / GGA hydrogels in particular enhanced wound healing by effectively promoting tissue regeneration, which was characterized by thinner epidermal thickness, increased blood vessel and hair follicles density, and higher collagen deposition and fiber alignment. Given these characteristics, the GH / GGA hydrogels produced in this study demonstrates potential in various biomedical applications, including wound treatment and tissue regeneration, where ROS oxidative damage is involved 7 . Hydrogels can be useful tools to promote wound healing, since they adhere to irregular wound shapes and act as a temporary matrix during healing.…”

Section: Gelatinmentioning

confidence: 99%

“…Therefore, skin tissue engineering has enticed considerable heedfulness from researchers as an optimistic approach for repairing partial/ full thickness burn tissue. [5][6][7][8][9][10][11][12] Moreover in the current review, various hydrogels with optimum biocompatibility and biodegradability have been widely investigated for use in skin tissue engineering. However, the biomaterials meant for the formulating the hydrogels, Collagen, Gelatin, Silk fibroin, Alginate, and Chitosan were found to be promising for skin tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Current Review on Polymeric Hydrogel Based

Kiruba¹,

Arjun²,

Rajan³

2021

Int J Life Sci Pharm Res

View full text Add to dashboard Cite

Skin tissue defects have become one of the major sources of mortality and morbidity among all age group people worldwide. Skin tissue engineering has enticed considerable heedfulness from researchers as an optimistic approach for repairing partial/ full thickness burn tissue. Skin is a highly vascularized, bio mineralized composite material composed of fibroblasts and collagen surrounded by specialized extracellular matrix with high mechanical strength and structural complexity. Although the auto grafts and allografts were regarded as the high attainment for wound repair, the approach was limited due to their inability revascularize and mimicking the damaged tissue. Further, the Polymeric hydrogels are very attractive skin tissue engineering scaffolds. The structural similarity of the polymeric hydrogels to the skin extracellular matrix provides additional benefits for non-invasive tissue repair. Owing to their poor healing ability, tissue regeneration was found to be challenging in skin tissue defects. However due to its excellent moisture retaining capabilities, biocompatibility and biodegradability several researchers shown considerable interest in potential applications of the hydrogels for skin tissue repair.Furthermore, recent progress involves the development of hydrogels with ideal mechanical and fast stimulus responsive characteristics. Moreover, hydrogels with structural similarity to the skin extracellular matrix up regulate the cell material interactions for quicker skin tissue repair and more regulated stimulus response changes in the microenvironment. This current review focused on the applications of both the synthetic and natural polymers involved in the formulation of the hydrogels for the skin tissue regeneration. Furthermore, understanding the polymers simultaneously reducing the complexity of building hydrogels should be the aim of the future research in the skin tissue regenerative medicine field.

show abstract

Section: Gelatinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Current Review on Polymeric Hydrogel Based

Kiruba¹,

Arjun²,

Rajan³

2021

Int J Life Sci Pharm Res

View full text Add to dashboard Cite

show abstract

“…In traditional hydrogels, the polymer network cross-linked by covalent bonds is irreversible, and is often too brittle that could easily fatigue. Reversible dynamical covalent interactions, such as imine bonds (Ying et al, 2014;Haldar et al, 2015;, disulfide bonds (Canadell et al, 2011;Deng et al, 2012;, phenylboronate complexations (Appel et al, 2015;Yesilyurt et al, 2016), acrylhydrazone bonds (Yu et al, 2015;Guo et al, 2017), Diels-Alder reactions (Liu and Chuo, 2013;Baker et al, 2017), and reversible radical reactions (Amamoto et al, 2012;Thi et al, 2020), are attractive strategies to develop elastic and high-strength hydrogels.…”

Section: Dynamic Covalent Bonds Interactionsmentioning

confidence: 99%

Recent Progress in 3D Printing of Elastic and High-Strength Hydrogels for the Treatment of Osteochondral and Cartilage Diseases

Dai

Sun

Leng

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Despite considerable progress for the regenerative medicine, repair of full-thickness articular cartilage defects and osteochondral interface remains challenging. This low efficiency is largely due to the difficulties in recapitulating the stratified zonal architecture of articular cartilage and engineering complex gradients for bone-soft tissue interface. This has led to increased interest in three-dimensional (3D) printing technologies in the field of musculoskeletal tissue engineering. Printable and biocompatible hydrogels are attractive materials for 3D printing applications because they not only own high tunability and complexity, but also offer favorable biomimetic environments for live cells, such as porous structure, high water content, and bioactive molecule incorporation. However, conventional hydrogels are usually mechanically weak and brittle, which cannot reach the mechanical requirements for repair of articular cartilage defects and osteochondral interface. Therefore, the development of elastic and high-strength hydrogels for 3D printing in the repairment of cartilage defects and osteochondral interface is crucial. In this review, we summarized the recent progress in elastic and high-strength hydrogels for 3D printing and categorized them into six groups, namely ion bonds interactions, nanocomposites integrated in hydrogels, supramolecular guest–host interactions, hydrogen bonds interactions, dynamic covalent bonds interactions, and hydrophobic interactions. These 3D printed elastic and high-strength hydrogels may provide new insights for the treatment of osteochondral and cartilage diseases.

show abstract

“…Some recent studies have highlighted an important role of ROS signaling in coordinating wound healing. 64 Though the oxygen has a key role in mediating wound repair is well known, the significance of cellular oxygen understanding in healing mechanisms is still a new area. 65 We can also establish either animal models or epithelial cells in vitro culture to study their migratory behavior and their roles to play in wound healing, such as intestinal anastomotic healing and so on.…”

Section: Epithelial Cellsmentioning

confidence: 99%

“…There are a quantity of epithelial signaling events come into play roles to mediate wound closure. Some recent studies have highlighted an important role of ROS signaling in coordinating wound healing 64 . Though the oxygen has a key role in mediating wound repair is well known, the significance of cellular oxygen understanding in healing mechanisms is still a new area 65 …”

Section: Proliferative Phasementioning

confidence: 99%