In situ forming hydrogels based on chitosan for drug delivery and tissue regeneration

Liu, Li; Gao, Qi; Lü, Xuemin; Zhou, Huifang

doi:10.1016/j.ajps.2016.07.001

Cited by 192 publications

(106 citation statements)

References 82 publications

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“…Unlike other minimally invasive delivery approaches that require polymer injection and in situ gelation, gels made using cryopolymerization are able to retain predefined geometries, architecture, and porosity posti-njection [62,63,65,75,76,77,78]. Similarly, physical properties of cryogels were dependent on the fabrication temperature.…”

Section: Discussionmentioning

confidence: 99%

Injectable Hyaluronic Acid-co-Gelatin Cryogels for Tissue-Engineering Applications

et al. 2018

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Polymeric scaffolds such as hydrogels can be engineered to restore, maintain, or improve impaired tissues and organs. However, most hydrogels require surgical implantation that can cause several complications such as infection and damage to adjacent tissues. Therefore, developing minimally invasive strategies is of critical importance for these purposes. Herein, we developed several injectable cryogels made out of hyaluronic acid and gelatin for tissue-engineering applications. The physicochemical properties of hyaluronic acid combined with the intrinsic cell-adhesion properties of gelatin can provide suitable physical support for the attachment, survival, and spreading of cells. The physical characteristics of pure gelatin cryogels, such as mechanics and injectability, were enhanced once copolymerized with hyaluronic acid. Reciprocally, the adhesion of 3T3 cells cultured in hyaluronic acid cryogels was enhanced when formulated with gelatin. Furthermore, cryogels had a minimal effect on bone marrow dendritic cell activation, suggesting their cytocompatibility. Finally, in vitro studies revealed that copolymerizing gelatin with hyaluronic acid did not significantly alter their respective intrinsic biological properties. These findings suggest that hyaluronic acid-co-gelatin cryogels combined the favorable inherent properties of each biopolymer, providing a mechanically robust, cell-responsive, macroporous, and injectable platform for tissue-engineering applications.

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Section: Discussionmentioning

confidence: 99%

Injectable Hyaluronic Acid-co-Gelatin Cryogels for Tissue-Engineering Applications

et al. 2018

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“…PEC are formed by polycations and polyanions and their pH-responsibility is the effect of electrostatic interactions. 85 Example of PEC hydrogel is chitosan/carboxymethyl cellulose complex, which similarly to chitosan/GP system, provided pHdependent thermo-sensitive gelation. 86 Storage modulus of this hydrogel was around 100 kPa at 378C.…”

Section: Physical Methodsmentioning

confidence: 99%

“…Obtaining of pH‐sensitive hydrogels is also possible with use of polyelectrolyte complexes (PEC). PEC are formed by polycations and polyanions and their pH‐responsibility is the effect of electrostatic interactions . Example of PEC hydrogel is chitosan/carboxymethyl cellulose complex, which similarly to chitosan/GP system, provided pH‐dependent thermo‐sensitive gelation .…”

Section: Injectable Hydrogels In Cartilage Engineeringmentioning

confidence: 99%

Injectable hydrogels and nanocomposite hydrogels for cartilage regeneration

Jeznach

Kołbuk

Sajkiewicz³

2018

J Biomedical Materials Res

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Cartilage loss due to age-related degeneration and mechanical trauma is a significant and challenging problem in the field of surgical medicine. Unfortunately, cartilage tissue can be characterized by the lack of regenerative ability. Limitations of conventional treatment strategies, such as auto-, allo-, and xenografts or implants stimulate an increasing interest in the tissue engineering approach to cartilage repair. This review discusses the application of polymer-based scaffolds, with an emphasis on hydrogels in cartilage tissue engineering. We highlight injectable hydrogels with various micro- and nanoparticles, as they constitute a novel and attractive type of scaffolds. We discuss advantages, limitations, and future perspectives of injectable nanocomposite hydrogels for cartilage tissue regeneration. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2762-2776, 2018.

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“…Different biodegradable polymers have been used for the development of in situ gel formulations such as alginic acid, gellan gum, xyloglucan, chitosan, pectin, poly(D-lactic acid), etc. In situ gel formulations have unique advantages such as sustained drug action when compared to the conventional therapeutics [88]. Chitosan-based in situ gels have been developed for the intranasal administration of drugs (Table 2).…”

Section: In Situ Gelmentioning

confidence: 99%

Chitosan-Based Nanocarriers for Nose to Brain Delivery

Aderibigbe

Naki

2019

Applied Sciences

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In the treatment of brain diseases, most potent drugs that have been developed exhibit poor therapeutic outcomes resulting from the inability of a therapeutic amount of the drug to reach the brain. These drugs do not exhibit targeted drug delivery mechanisms, resulting in a high concentration of the drugs in vital organs leading to drug toxicity. Chitosan (CS) is a natural-based polymer. It has unique properties such as good biodegradability, biocompatibility, mucoadhesive properties, and it has been approved for biomedical applications. It has been used to develop nanocarriers for brain targeting via intranasal administration. Nanocarriers such as nanoparticles, in situ gels, nanoemulsions, and liposomes have been developed. In vitro and in vivo studies revealed that these nanocarriers exhibited enhanced drug uptake to the brain with reduced side effects resulting from the prolonged contact time of the nanocarriers with the nasal mucosa, the surface charge of the nanocarriers, the nano size of the nanocarriers, and their capability to stretch the tight junctions within the nasal mucosa. The aforementioned unique properties make chitosan a potential material for the development of nanocarriers for targeted drug delivery to the brain. This review will focus on chitosan-based carriers for brain targeting.

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In situ forming hydrogels based on chitosan for drug delivery and tissue regeneration

Cited by 192 publications

References 82 publications

Injectable Hyaluronic Acid-co-Gelatin Cryogels for Tissue-Engineering Applications

Injectable Hyaluronic Acid-co-Gelatin Cryogels for Tissue-Engineering Applications

Injectable hydrogels and nanocomposite hydrogels for cartilage regeneration

Chitosan-Based Nanocarriers for Nose to Brain Delivery

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