2019
DOI: 10.1016/j.ijpharm.2019.118564
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In-situ forming implants loaded with chlorhexidine and ibuprofen for periodontal treatment: Proof of concept study in vivo

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Cited by 30 publications
(24 citation statements)
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“…The combination of drugs to increase the effectiveness and decrease the necessary amount of the applied medicines is a long-standing endeavor. Aspirin and erythropoietin-filled locally used hydrogels were demonstrated for the treatment of periodontal disease, and another recent example studied the combined application of CHX and ibuprofen in intra-pockets administration and proved their clinical relevance [ 47 , 48 ]. Our newly created CHX/Metr-containing NCHG system is novel, and clinically promising, evidenced by the half-day presence of the antibiotics, and the at least one-week-long-lasting antimicrobial environment.…”
Section: Resultsmentioning
confidence: 99%
“…The combination of drugs to increase the effectiveness and decrease the necessary amount of the applied medicines is a long-standing endeavor. Aspirin and erythropoietin-filled locally used hydrogels were demonstrated for the treatment of periodontal disease, and another recent example studied the combined application of CHX and ibuprofen in intra-pockets administration and proved their clinical relevance [ 47 , 48 ]. Our newly created CHX/Metr-containing NCHG system is novel, and clinically promising, evidenced by the half-day presence of the antibiotics, and the at least one-week-long-lasting antimicrobial environment.…”
Section: Resultsmentioning
confidence: 99%
“…Farahmand et al 58 reported that the Ibuprofen gel, as an adjunct to SRP, might open up new horizons in the management of periodontal therapy and could be used to supplement the treatment to determine the inflammatory process and clinical signs of the disease more rapidly. Batool et al 59 injected 1.5% chlorhexidine and ibuprofen into the periodontal pockets in an experimental periodontitis mouse model and reported a reduction in inflammation and an improvement in periodontal wound healing through inflammatory cell scoring after treatment. Furthermore, another study showed that electrospun polycaprolactone scaffold functionalized with ibuprofen significantly improved the clinical attachment, reduced inflammation-induced bone loss, efficiently and differentially controlled inflammatory and migratory gingival cell reaction, and probably promoted periodontal regeneration.…”
Section: Discussionmentioning
confidence: 99%
“…Palatal root areas of the first molars were analyzed to examine the extension of epithelial downgrowth, connective tissue attachment and alveolar bone loss. For histomorphometric analysis: epithelial attachment (EA) was measured from the cemento‐enamel junction (CEJ) to the apical limit of the epithelium, fibrous connective tissue attachment (FA) was measured from the base of the apical limit of EA up till the beginning of the dense fibrous connective tissue fibers, attachment level (AL) corresponds to EA+FA and the alveolar bone level (BL) was measured from CEJ to alveolar bone crest (ABC) using imaging software 23,24 . Measurements were performed by a researcher blinded to the samples’ allocation.…”
Section: Methodsmentioning
confidence: 99%
“…up till the beginning of the dense fibrous connective tissue fibers, attachment level (AL) corresponds to EA+FA and the alveolar bone level (BL) was measured from CEJ to alveolar bone crest (ABC) using imaging software ‡ ‡ ‡ . 23,24 Measurements were performed by a researcher blinded to the samples' allocation.…”
Section: Histological Analysismentioning
confidence: 99%