In situ-forming injectable hydrogels for regenerative medicine

Yang, Jeong-A; Yeom, Junseok; Hwang, Byung Woo; Hoffman, Allan S.; Hahn, Sei Kwang

doi:10.1016/j.progpolymsci.2014.07.006

Cited by 468 publications

(307 citation statements)

References 128 publications

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“…Another class of biocompatible materials are hydrogel-based materials, such as with PEG and poly(vinyl-alcohol) (PVA) [40,41]. Hydrogels are threedimensional polymeric networks that retain water, mimicking the body's extracellular matrix (ECM) [40] and are commonly used for tissue engineering applications [41].…”

Section: Biocompatible and Biodegradable Materialsmentioning

confidence: 99%

“…Hydrogels are threedimensional polymeric networks that retain water, mimicking the body's extracellular matrix (ECM) [40] and are commonly used for tissue engineering applications [41]. They offer unique advantages such as tunable material properties, the possibility of incorporating chemical functional groups, and the ability to encapsulate drugs or cells [21,40,41].…”

Section: Biocompatible and Biodegradable Materialsmentioning

confidence: 99%

“…This could occur if high optical powers are used, for example, to compensate for optical loss in the system, light is focused accidentally to a small area, or if phototoxic ultraviolet (UV) light is needed to form the device, such as UV-cross-linking of in situ forming hydrogels [40]. The primary mechanisms of light damage to cells are photothermal and photochemical [77,78].…”

Section: Other Safety Considerationsmentioning

confidence: 99%

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Toward biomaterial-based implantable photonic devices

et al. 2017

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Optical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for use in vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a pathway to improve health monitoring, diagnostics, and light-activated therapies.

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Section: Biocompatible and Biodegradable Materialsmentioning

confidence: 99%

Section: Biocompatible and Biodegradable Materialsmentioning

confidence: 99%

Section: Other Safety Considerationsmentioning

confidence: 99%

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Toward biomaterial-based implantable photonic devices

et al. 2017

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“…They are usually classified according to the nature of the crosslinks established between the polymer chains into chemical or physical hydrogels. Chemical hydrogels involve the formation of covalent bonds, while physical hydrogels are obtained when physical interactions are established between the polymeric chains (molecular entanglement, ionic interaction and hydrogen bonding) [168,210]. Hydrogels display many of the desired characteristics of an ideal skin substitute, as they promote wound debridement, while providing a suitable moist environment to stimulate the healing process.…”

Section: Hydrogel Bioinksmentioning

confidence: 99%

“…The interest in these materials mainly relies on the fact that their composition and structure resembles the ECM properties of native tissues [26]. These polymers can also be easily converted into either physical or chemical hydrogels under cell-compatible conditions through a myriad of crosslinking pathways [210]. In addition, certain natural polymers (e.g., collagen) also present cell-proteolytic domains and/or adhesion motifs, providing recognition sites for embedded cells and allowing the cellmediated degradation of the hydrogel network in a similar way to the remodelling of native ECM.…”

Section: Hydrogel Bioinksmentioning

confidence: 99%

Advances in bioprinted cell-laden hydrogels for skin tissue engineering

et al. 2017

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Bioprinting technologies are powerful additive biofabrication techniques to produce cellular constructs for skin tissue engineering owing to their unique ability to precisely pattern living and non-living materials in predefined spatial locations. This unique feature, combined with the computer controlled printing and medical imaging techniques, enable researchers and clinicians to generate patient specific constructs partly replicating the intricate compositional and architectural organization of the skin. Bioprinting has been used to automatically dispense hydrogels with skin cells located in prescribed sites that promote skin formation in vitro and in vivo. Current skin bioprinting approaches mostly rely on the sequential printing of fibroblasts and keratinocytes embedded within a homogeneous hydrogel. Although such approaches have already been translated to pre-clinical scenarios, they still present limitations in terms of fully replicating the cellular and extracellular matrix (ECM) heterogeneity in native skin. The success of bioprinting for skin repair strongly depends on the design of printable bioinks capable of supporting the function of printed cells and stimulating the production of new ECM components. To better mimic the human skin, novel developments in dedicated bioprinting technologies, in the design of bioinks, as well as in the printing of vascularised constructs are necessary. This paper presents an overview regarding the use of bioprinting for skin tissue engineering applications. The operating principles of bioprinting technologies are outlined along with requirements of printed skin constructs. Finally, preclinical results are summarized and future perspectives for the field are highlighted.

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Injectable Hydrogels: Properties and Applications

Park

Парк

2017

Encyclopedia of Polymer Science and Technology

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In situ forming hydrogels have been widely used as therapeutic implants and vehicles for a broad range of biomedical applications, including tissue regenerative medicine and drug delivery because of their biocompatibility and multitunable properties. These hydrogel materials have received considerable attention as injectable matrices because of easy encapsulation of the therapeutic agents during the hydrogel network formation as well as their minimally invasive injection into the target sites. In addition, the injectable hydrogel has also the advantage of an easy application to irregular defect sites. Furthermore, it is widely used as an artificial extracellular matrix because of its structural similarity with the native extracellular matrix of the human body and its multitunable properties. Various synthetic, natural, and bioinspired materials have been developed as injectable hydrogels by using different cross‐linking strategies. In this article, we discuss how the functional hydrogels are created with tunable physical, chemical, and biological properties. In particular, we focus on emerging techniques used to apply advanced hydrogel materials for tissue regenerative medicine.

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In situ-forming injectable hydrogels for regenerative medicine

Cited by 468 publications

References 128 publications

Toward biomaterial-based implantable photonic devices

Toward biomaterial-based implantable photonic devices

Advances in bioprinted cell-laden hydrogels for skin tissue engineering

Injectable Hydrogels: Properties and Applications

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