In situ forming parenteral drug delivery systems: an overview

Packhaeuser, Claudia B.; Schnieders, Julia; Oster, Christine G.; Kissel, Thomas

doi:10.1016/j.ejpb.2004.03.003

Cited by 371 publications

(239 citation statements)

References 45 publications

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“…25,26 However, several issues associated with these polymers have been raised such as the presence of residual organic solvents, toxicity of photoinitiators, and complex material preparation. 25,27 …”

Section: Discussionmentioning

confidence: 99%

“…Secondly, localized or systemic drug delivery can be achieved for prolonged periods of time, typically ranging from one to several months. 27 For instance, polyethylene glycol-oligo-glycolyl-acrylate can be crosslinked to encapsulate drugs using a photoinitiator such as eosin. However, such methods are restricted to the correct wavelength and the accessibility to a light source.…”

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confidence: 99%

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Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments

Song

Chen²,

Yan³

et al. 2011

IJN

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Rosette nanotubes (RNTs) are novel, biomimetic, injectable, self-assembled nanomaterials. In previous studies, materials coated with RNTs have significantly increased cell growth (eg, osteoblasts, chondrocytes, and endothelial cells) due to the favorable cellular environment created by RNTs. It has also been suggested that the tubular RNT structures formed by base stacking and hydrophobic interactions can be used for drug delivery, and this possibility has not been studied to date. Here we investigated methods to load and deliver tamoxifen (TAM, a hydrophobic anticancer drug) using two different types of RNTs: single- base RNTs and twin-base RNTs. Drug-loaded RNTs were characterized by nuclear magnetic resonance spectroscopy, diffusion-ordered nuclear magnetic resonance spectroscopy (DOSY NMR), and ultraviolet-visible (UV-Vis) spectroscopy at different ratios of twin-base RNTs to TAM. The results demonstrated successful incorporation of hydrophobic TAM into RNTs. Importantly, because of the hydrophilicity of the outer surface of the RNTs, TAM-loaded RNTs were dissolved in water, and thus have great potential to deliver hydrophobic drugs in various physiological environments. The results also showed that twin-base RNTs further improved TAM loading. Therefore, this study demonstrated that hydrophobic pharmaceutical agents (such as TAM), once considered hard to deliver, can be easily incorporated into RNTs for anticancer treatment purposes.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments

Song

Chen²,

Yan³

et al. 2011

IJN

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“…Biodegradable injectable in situ forming drug delivery systems may offer an attractive method of protein delivery and could possibly extend the patent life of therapeutic drugs that are proteins in nature [4]. Joshi reported successful entrapment, protection and control of in vitro release of the model protein macromolecule alpha-amylase for up to 6 days and it can therefore be considered for in vivo investigation [62].…”

Section: Applications In Protein and Peptide Deliverymentioning

confidence: 99%

“…In situ gel (ISG) systems have been introduced in recent decades for the purpose of drug delivery and injectable tissue engineering [2,3]. In tissue engineering, a biocompatible system is employed to repair or replace portions of tissue or whole tissues such as bone, cartilage, blood vessels, skin, muscle, etc., while their use in drug delivery is mainly directed at controlling and sustaining the release of the administered drug [4,5].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Parenteral in situ Gel Formulation Based on smart PLGA polymer: Concepts to Decrease Initial Drug Burst and extend drug release

Ahmed¹,

Hussain²

2017

Biodegradable Polymers: Recent Developments and New Perspectives

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“…For example, injectable in situ forming implant based on N-steroyl-L-alanine methyl ester and N-steroyl-Lalanine ethyl ester have been successfully prepared as a matrix where the therapeutic agents could be entrapped and then released from the organogels via diffusion or degradation (Plourde et al, 2005). Subcutaneous administration is frequently used as a route since it is convenient to administrate, and can avoid the first-pass metabolism, prolong the retention time, reduce the frequency of administration and improve the bioavailability of drugs (Packhaeuser et al, 2004;Madan et al, 2009;Giri et al, 2012;Ghasemi et al, 2016). The organogel, however, could be injected through syringe needle with the aid of ''gelation inhibitor'', which belongs to some of the amphiphilic solvents.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled drug delivery system based on low-molecular-weight bis-amide organogelator: synthesis, properties and in vivo evaluation

Cao

et al. 2016

Drug Delivery

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(2016) Self-assembled drug delivery system based on low-molecular-weight bisamide organogelator: synthesis, properties and invivo evaluation, Drug Delivery, 23:8, 3168-3178, DOI: 10.3109/10717544.2016 RESEARCH ARTICLESelf-assembled drug delivery system based on low-molecular-weight bis-amide organogelator: synthesis, properties and in vivo evaluation Zhen Li, Jinxu Cao, Heran Li, Hongzhuo Liu, Fei Han, Zhenyun Liu, Chao Tong, and Sanming Li School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, P.R. China Abstract Context: Orgnaogels based on amino acid derivatives have been widely used in the area of drug delivery. Objective: An organogel system based on L-lysine derivatives was designed and prepared to induce a thermal sensitive implant with higher transition temperature, better mechanical strength, and shorter gelation time. Materials and methods: The organogel was prepared by injectable soybean oil and methyl (S)-2,5-ditetradecanamidopentanoate (MDP), which was synthesized for the first time. Candesartan cilexetil (CC) was chosen as model drug. Different formulations were designed and optimized by response surface method. Thermal, rheology properties, and gelation kinetics of the optimized formulation had been characterized. The release behaviors in vitro, as well as in vivo were evaluated in comparison with the oily solution of drugs. Finally, the local inflammation response of in situ organogel was assessed by histological analysis. Results and discussion: Results showed that the synthesized gelator, MDP, had a good gelation ability and the organogels obtained via the self-assembly of gelators in vegetable oils exhibited great thermal and rheology properties, which guaranteed their state in body. In vivo pharmacokinetic demonstrated that the organogel formulation could extend the drug release and maintain a therapeutically effective plasma concentration at least 10 d. In addition, this implant showed acceptable moderate inflammation. Conclusion: The in situ forming L-lysine-derivative-based organogel could be a promising matrix for sustained drug delivery of the drugs with low solubility. KeywordsBiocompatibility, gelator, in situ implant system, in vivo release, organogel History

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In situ forming parenteral drug delivery systems: an overview

Cited by 371 publications

References 45 publications

Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments

Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments

Preparation of Parenteral in situ Gel Formulation Based on smart PLGA polymer: Concepts to Decrease Initial Drug Burst and extend drug release

Self-assembled drug delivery system based on low-molecular-weight bis-amide organogelator: synthesis, properties and in vivo evaluation

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