In-situ forming PEG-engineering hydrogels with anti-fouling characteristics as an artificial vitreous body

Wang, Ting; Deng, Jing Lan; Ran, Ruijin; Shi, Wei; Gao, Yunxia; Ren, Xiang; Cao, Jun; Zhang, Ming

doi:10.1016/j.cej.2022.137486

Cited by 17 publications

(12 citation statements)

References 39 publications

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“…This great performance of PSBMA can be understood from the anti-adhesion mechanism of zwitterionic hydrogel. It has been reported that the zwitterionic material with strong hydration capacity could form a stable hydration layer on the surface via electrostatic interaction with water molecules. , Meanwhile, PEG polymers also demonstrated to have an excellent hydration effect through multiple hydrogen bonding interactions with water . Beneficial from the above advantages of zwitterionic and PEG groups, our PZOPZ hydrogel could generate a stable hydration layer to effectively prevent bacterial adhesion, thus providing a clean microenvironment for wound healing (Figure S9).…”

Section: Resultsmentioning

confidence: 93%

“…48,49 Meanwhile, PEG polymers also demonstrated to have an excellent hydration effect through multiple hydrogen bonding interactions with water. 30 Beneficial from the above advantages of zwitterionic and PEG groups, our PZOPZ hydrogel could generate a stable hydration layer to effectively prevent bacterial adhesion, thus providing a clean microenvironment for wound healing (Figure S9). 50−54 Hypotoxicity is the most essential requirement for applications of hydrogel dressings in wound management.…”

Section: Anti-bacterial Adhesion and Biocompatibilitymentioning

confidence: 99%

“…However, compared to the preformed zwitterionic hydrogels, in situ -forming zwitterionic hydrogels are more appealing as they can cover complex shapes and deep wounds well. To date, an increasing number of in situ -forming zwitterionic hydrogels have been developed for wound healing by adopting facile cross-linking chemistry. − For example, some recent studies have demonstrated in situ gelation of PSBMA hydrogels via thiol-ene click reaction and realized favorable adaptable coverage for rapid wound healing. − Nonetheless, preparation of these hydrogels requires delicate adjustment of the ratio of thiols to enes for proper gelation time and involves usage of thiol or ene cross-linkers, thereby greatly increasing their application complexity and having high risk of leakage of small molecules. In contrast, in situ gel formation triggered by physiologic temperature without additional cross-linking chemicals is more relevant and valuable for clinical wound management.…”

Section: Introductionmentioning

confidence: 99%

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Thermoresponsive Self-Healing Zwitterionic Hydrogel as an In Situ Gelling Wound Dressing for Rapid Wound Healing

Wang

Chen

et al. 2022

ACS Appl. Mater. Interfaces

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It is highly desired yet challenging to fabricate biocompatible injectable self-healing hydrogels with anti-bacterial adhesion properties for complex wounds that can autonomously adapt to different shapes and depths and can promote angiogenesis and dermal collagen synthesis for rapid wound healing. Herein, an injectable zwitterionic hydrogel with excellent self-healing property, good cytocompatibility, and antibacterial adhesion was developed from a thermoresponsive ABA triblock copolymer poly[(N-isopropyl acrylamide)-co-(butyl acrylate)-co-(sulfobetaine methacrylate)]-b-poly(ethylene glycol)-b-poly[(N-isopropyl acrylamide)-co-(butyl acrylate)-co-(sulfobetaine methacrylate)] (PZOPZ). The prepared PZOPZ hydrogel exhibits a distinct thermal-induced sol−gel transition around physiological temperature and could be easily applied in a sol state and in situ gelled to adapt complex wounds of different shapes and depths for complete coverage. Meanwhile, the hydrogel possesses a rapid selfhealing ability and can recover autonomously from damage to maintain structural and functional integrity. In addition, the CCK-8 and 2D/3D cell culture experiments revealed that the PZOPZ hydrogel dressing shows low cytotoxicity to L929 cells and can effectively prevent the adhesion of Staphylococcus aureus and Escherichia coli. In vivo investigations verified that the PZOPZ hydrogel could increase angiogenesis and dermal collagen synthesis and shorten the transition from the inflammatory to the proliferative stage, thereby providing more favorable conditions for faster wound healing. Overall, this work provides a promising strategy to develop injectable zwitterionic hydrogel dressings with multiple functions for clinic wound management.

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Section: Resultsmentioning

confidence: 93%

Section: Anti-bacterial Adhesion and Biocompatibilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thermoresponsive Self-Healing Zwitterionic Hydrogel as an In Situ Gelling Wound Dressing for Rapid Wound Healing

Wang

Chen

et al. 2022

ACS Appl. Mater. Interfaces

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“…Once the driving force behind the attractive polybetaine behaviors is fully understood, potential applications associated with a combination of the responsive properties of polyzwitterionic polymers with the supramolecular assembly characteristics of block copolymers may continue to develop from preliminary studies. 8,10 As noted earlier, polybetaines are also of particular interest for their antifouling applications of technological interest in the biomedical 1,2 and membrane filtration 3−5 fields. In particular, sulfobetaine methacrylate (SBMA) polyzwitterionic polymers have been shown to form ultralow biofouling surfaces when grafted to a surface with a sufficient high density.…”

Section: Introductionmentioning

confidence: 95%

“…In particular, sulfobetaine methacrylate (SBMA) polyzwitterionic polymers have been shown to form ultralow biofouling surfaces when grafted to a surface with a sufficient high density. 3,6 Several studies have indicated that sulfobetaine hydrogel materials 1,2 and polymer brush films 5,7 can be highly resistant to nonspecific protein binding, making these materials attractive as suitable materials for medical implants. 1,11 The presence of a strong hydration layer in polybetaine brush films has been offered as an explanation of the characteristically low friction in polymer layers of this kind.…”

Section: Introductionmentioning

confidence: 99%

Molecular Dynamics Simulation of the Influence of Temperature and Salt on the Dynamic Hydration Layer in a Model Polyzwitterionic Polymer PAEDAPS

Clark,

Prabhu,

Douglas

2023

J. Phys. Chem. B

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We investigate the hydration of poly(3-[2-(acrylamido) ethyldimethylammonio] propanesulfonate) over a range of temperatures in pure water and with the inclusion of 0.1 mol/L NaCl using atomistic molecular dynamics simulation. Drawing on concepts drawn from the field of glass-forming liquids, we use the Debye−Waller parameter () for describing the water mobility gradient around the polybetaine backbone extending to an overall distance ≈18 Å. The water mobility in this layer is defined through the mean-square water molecule displacement at a time on the order of water's β-relaxation time. The brushlike topology of polybetaines leads to two regions in the dynamic hydration layer. The inner region of ≈10.5 Å is explored by pendant group conformational motions, and the outer region of ≈7.5 Å represents an extended layer of reduced water mobility relative to bulk water. The dynamic hydration layer extends far beyond the static hydration layer, adjacent to the polymer.

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An Injectable Self‐Crosslinked Wholly Supramolecular Polyzwitterionic Hydrogel for Regulating Microenvironment to Boost Infected Diabetic Wound Healing

Pang

Wang

Yao

et al. 2023

Adv Funct Materials

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It is highly desirable yet significantly challenging to fabricate injectable, self‐crosslinked, self‐fused, and antifouling polyzwitterionic hydrogels, whose successful preparation will expand their application scope in biomedical fields. Herein, for the first time, a novel zwitterionic monomer, carboxybetaine urethane acrylate (CBUTA) is designed and synthesized with a urethane group and zwitterion on the same side chain. The strong inter‐urethane H‐bonds and zwitterionic dipole–dipole interactions of side chains contribute to self‐crosslinked wholly supramolecular polyzwitterionic hydrogel that is directly formed from photoinitiated polymerization of CBUTA aqueous solution without adding any chemical crosslinkers. After being swollen in water, the polyCBUTA (PCBUTA) hydrogel is squeezed into small particles and freeze‐dried to obtain hydrogel powder. The injectable and wholly zwitterionic supramolecular PCBUTA hydrogel can be easily reconstructed by mixing hydrogel powder with water due to the recombination of H‐bonds of urethane groups and zwitterionic dipole–dipole interactions. The re‐formed PCBUTA hydrogel exhibits an excellent self‐fused and antifouling ability, and this injectable PCBUTA hydrogel, endowed with a microenvironment‐regulated function, demonstrates excellent glucose consumption, antioxidation, antibacterial, and angiogenesis ability, thus accelerating the infected diabetic wound healing. Overall, this work provides a promising strategy to develop injectable and wholly zwitterionic hydrogels that will find broad biomedical applications.

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In-situ forming PEG-engineering hydrogels with anti-fouling characteristics as an artificial vitreous body

Cited by 17 publications

References 39 publications

Thermoresponsive Self-Healing Zwitterionic Hydrogel as an In Situ Gelling Wound Dressing for Rapid Wound Healing

Thermoresponsive Self-Healing Zwitterionic Hydrogel as an In Situ Gelling Wound Dressing for Rapid Wound Healing

Molecular Dynamics Simulation of the Influence of Temperature and Salt on the Dynamic Hydration Layer in a Model Polyzwitterionic Polymer PAEDAPS

An Injectable Self‐Crosslinked Wholly Supramolecular Polyzwitterionic Hydrogel for Regulating Microenvironment to Boost Infected Diabetic Wound Healing

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