Ab initio many-body perturbation theory (MP2/ 6-311??G(,dp)), density functional theory (B3LYP/6-31??G(d,p)) and self-consistent reaction field (IEF-PCM UA HF/6-31G(d)) calculations have been used to study the CO 2 capture reagents NH 3 , 2-hydroxyethylamine (MEA), diaminoethane (EN), 2-amino-1-propanol (2A1P), diethanolamine (DEA), N-methyl-2-hydroxyethylamine (N-methylMEA), 2-amino-2-methyl-1-propanol (AMP), trishydroxymethylaminomethane (tris), piperazine (PZ) and piperidine (PD). This study involved full conformational searches of the capture amines in their native and protonated forms, and their carbamic acid and carbamate derivatives. Using this data, we were able to compute Boltzmann-averaged thermodynamic values for the amines, carbamates and carbamic acid derivatives, as well as equilibrium constants for a series of 'universal' aqueous capture reactions. Important findings include (i) relative pK a values for the carbamic acid derivatives are a useful measure of carbamate stability, due to a particular chemical resonance which is also manifest in short computed N-CO 2 H bonds at both levels of theory, (ii) the computational results for sterically hindered amines such as AMP and tris are consistent with these species forming carbamates which readily hydrolyse and (iii) the amine-catalysed reaction between OH -and CO 2 to generate bicarbonate correlates with amine pK a . Thermodynamic data from the ab initio computations predicts that the heterocycles PD and PZ and the acyclic sorbent EN are good choices for a capture solvent. AMP and tris perform poorly in comparison.