In-situ gel: A smart carrier for drug delivery

Garg, Akash; Agrawal, Rutvi; Singh Chauhan, Chetan; Deshmukh, Rohitas

doi:10.1016/j.ijpharm.2024.123819

Cited by 20 publications

(5 citation statements)

References 112 publications

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“…Variations in the physiological environment's pH may allow for modifications to the polymer's ionization state, conformation, and solubility, which could lead to the drug carrier gelling [8]. The gelation behavior of pH-responsive formulations is influenced by the pKa of the constituent polymer [9]. pH-sensitive polymeric solutions that are weakly acidic or basic usually gel at pH values that are higher than their pKa values, respectively [8].…”

Section: Systems Used In In Situ Gelling Formulation a Ph Sensitive S...mentioning

confidence: 99%

From Liquid to Solid: Unravelling the Magic of In-Situ Gels

Brahmavale

2024

IJRASET

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In situ gelling formulations are liquid at room temperature and transform into gels upon application to the body in response to various stimuli (e.g., pH, temperature, ionic composition). Incorporating drug nanoparticles into these systems enhances their biomedical utility by prolonging drug release, reducing dosing frequency, and improving patient outcomes. These formulations, particularly those with mucoadhesive polymers, offer promising potential for targeted drug delivery and prolonged drug retention at specific sites. A review of clinical properties of in situ gelling systems investigated over the past decade underscores their effectiveness and challenges in achieving optimal dosage forms.

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Section: Systems Used In In Situ Gelling Formulation a Ph Sensitive S...mentioning

confidence: 99%

From Liquid to Solid: Unravelling the Magic of In-Situ Gels

Brahmavale

2024

IJRASET

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“…Therefore, novel hydrogel biomaterials with smart properties to promote clinical practices in biomedicine and tissue regeneration engineering are needed. Smart responsive in situ hydrogels are extensively applied in bone tissue engineering ( Ali et al, 2024 ; Asadi et al, 2024 ; Zhou H. et al, 2024 ; Garg et al, 2024 ). This strategy can guide hydrogels to adapt to diverse shapes and depths of bone defects, which will promote integration with bone tissue.…”

Section: Application Of Exogenous Stimulus-responsive In Si...mentioning

confidence: 99%

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Wu,

Gai,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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The repair of irregular bone tissue suffers severe clinical problems due to the scarcity of an appropriate therapeutic carrier that can match dynamic and complex bone damage. Fortunately, stimuli-responsive in situ hydrogel systems that are triggered by a special microenvironment could be an ideal method of regenerating bone tissue because of the injectability, in situ gelatin, and spatiotemporally tunable drug release. Herein, we introduce the two main stimulus-response approaches, exogenous and endogenous, to forming in situ hydrogels in bone tissue engineering. First, we summarize specific and distinct responses to an extensive range of external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) to form in situ hydrogels created from biocompatible materials modified by various functional groups or hybrid functional nanoparticles. Furthermore, “smart” hydrogels, which respond to endogenous physiological or environmental stimuli (e.g., temperature, pH, enzyme, etc.), can achieve in situ gelation by one injection in vivo without additional intervention. Moreover, the mild chemistry response-mediated in situ hydrogel systems also offer fascinating prospects in bone tissue engineering, such as a Diels–Alder, Michael addition, thiol-Michael addition, and Schiff reactions, etc. The recent developments and challenges of various smart in situ hydrogels and their application to drug administration and bone tissue engineering are discussed in this review. It is anticipated that advanced strategies and innovative ideas of in situ hydrogels will be exploited in the clinical field and increase the quality of life for patients with bone damage.

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“…In other words, a hydrogel matrix should ensure physical and mechanical integrity to prove effective in its use as biomaterials during the lifetime of an application [ 1 , 2 ]. Because of the advances in hydrogel technologies and their versatile fabrication methods and tunable physical properties, hydrogel materials have been applied in a wide range of biomedical and engineering applications, ranging from cell culturing [ 3 ] to tissue engineering [ 4 , 5 , 6 ], sensors and actuators [ 7 , 8 ], drug delivery [ 9 , 10 ], and so on. In particular, this work focuses on the characterization of hydrogels used for dosimetric applications and, specifically, Fricke gel (FG) dosimetry.…”

Section: Introductionmentioning

confidence: 99%

Microscopic and Macroscopic Characterization of Hydrogels Based on Poly(vinyl-alcohol)–Glutaraldehyde Mixtures for Fricke Gel Dosimetry

Locarno,

Arosio,

Curtoni

et al. 2024

Gels

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In recent decades, hydrogels have emerged as innovative soft materials with widespread applications in the medical and biomedical fields, including drug delivery, tissue engineering, and gel dosimetry. In this work, a comprehensive study of the macroscopic and microscopic properties of hydrogel matrices based on Poly(vinyl-alcohol) (PVA) chemically crosslinked with Glutaraldehyde (GTA) was reported. Five different kinds of PVAs differing in molecular weight and degree of hydrolysis were considered. The local microscopic organization of the hydrogels was studied through the use of the 1H nuclear magnetic resonance relaxometry technique. Various macroscopic properties (gel fraction, water loss, contact angle, swelling degree, viscosity, and Young’s Modulus) were investigated with the aim of finding a correlation between them and the features of the hydrogel matrix. Additionally, an optical characterization was performed on all the hydrogels loaded with Fricke solution to assess their dosimetric behavior. The results obtained indicate that the degree of PVA hydrolysis is a crucial parameter influencing the structure of the hydrogel matrix. This factor should be considered for ensuring stability over time, a vital property in the context of potential biomedical applications where hydrogels act as radiological tissue-equivalent materials.

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In-situ gel: A smart carrier for drug delivery

Cited by 20 publications

References 112 publications

From Liquid to Solid: Unravelling the Magic of In-Situ Gels

From Liquid to Solid: Unravelling the Magic of In-Situ Gels

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Microscopic and Macroscopic Characterization of Hydrogels Based on Poly(vinyl-alcohol)–Glutaraldehyde Mixtures for Fricke Gel Dosimetry

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