In-situ gel of nifedipine for preeclampsia: Optimization, in-vitro and in-vivo evaluation

Karemore, Megha N.; Avari, Jasmine G.

doi:10.1016/j.jddst.2019.01.025

Cited by 16 publications

(12 citation statements)

References 47 publications

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“…Indeed, many trials were performed to prepare oily suspensions of sodium alginate with calcium carbonate alone but were not successful as they disseminated quickly after gelation, and this result was also observed by Karemore and Avari (Karemore and Avari, 2019).…”

Section: Preparation Of Oily In Situ Gelmentioning

confidence: 91%

Oily in situ gels as an alternative floating platform for ketoconazole release

Mohamed

Jaafar

Sabar

et al. 2020

ijrps

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Sodium alginate, calcium carbonate, and guar gum were mixed with oils such as olive oil (OO), sesame oil (SO), and medium chain triglyceride (MCT). The oily formulations were found to simplify the preparation of in situ floating gel. This was the aim of this study using ketoconazole (keto) as a model drug. The investigations for the floating property were established by In vitro gelling capacity study and In vitro floating study. Additionally, in vitro release study was applied to find the best formulations to delay the release of keto. Then, selected formulations were studied by FTIR and SEM. Lastly, in vivo gelation was performed to examine the gelation in the rat’s stomach. The results showed all formulations were floating after successful gelation as the least amount of sodium alginate to gel oils was 20% w/w. The gels in SO and OO were better than MCT in delaying keto release, and 30% w/w sodium alginate in SO was the best to delay the release of keto within 8 hours of the release study. Selected gels showed interactions between the keto molecules and the molecules of the gel contents by FTIR study, and SEM showed a difference in the internal structure of selected formulations. Lastly, the 30% w/w sodium alginate in SO proved to gel and remain in the rat's stomach in the following periods: 30 min, 1 hour, 2 hours, and after 8 hours. Oily suspension formulations showed floating properties in the stomach and slowed the release of keto and specifically 30% w/w of sodium alginate in SO.

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Section: Preparation Of Oily In Situ Gelmentioning

confidence: 91%

Oily in situ gels as an alternative floating platform for ketoconazole release

Mohamed

Jaafar

Sabar

et al. 2020

ijrps

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“…All of the formulas were physically examined using a visual method against a dark and white background. The pH was measured at room temperature with a digital pH meter that had previously been calibrated [14].…”

Section: Physical Appearance and Phmentioning

confidence: 99%

“…The time taken for the formed gel to dissolve were observed visually. The experiment was repeated in triplicate [11,14].…”

Section: In Vitro Gelling Studymentioning

confidence: 99%

“…The amount of time it takes the gelled mass to move upward (floating lag time) and the amount of time it stays afloat (total floating time) were recorded. The experiment was carried out three times [11,14].…”

Section: In Vitro Buoyancy Studymentioning

confidence: 99%

“…The average of two readings was used to calculate the viscosity. The rheological data were analyzed by using Farrow's equation [11,14].…”

Section: Measurement Of Viscositymentioning

confidence: 99%

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Development and Evaluation of Raft Forming Gastro Retentive Floating Drug Delivery System of Nizatidine by Design of Experiment

SAGAR

2022

Int J App Pharm

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Objective: The current research involves the formulation of a sustained-release gastro-retentive drug delivery system of nizatidine. Methods: Using 33 Box-Behnken designs, about 17 experiments were performed and evaluated for various parameters like physical appearance, pH, in vitro gelling study, in vitro buoyancy study, measurement of viscosity, density measurement, gel strength, raft resilience, drug content, acid neutralization capacity, in vitro dissolution, release kinetics and stability studies. Results: All the formulations exhibited good viscosity, density less than gastric fluid, gelling capacity retained, and buoyant for 12 h. Drug content ranges from 97.98 to 99.34 %, with a long neutralization period. The buoyancy lag time was found to be in the range of 15.34 to 26.12 sec and the % drug release at 12 h was between range from 85.67 to 99.45, with the highest release exhibited by F3. All formulations displayed zero order in vitro drug release>10 h with exceptional buoyancy properties. F3 was the optimized formulation and further subjected to FTIR and DSC study, concluding that compatibility of nizatidine with excipients in the formulation blend. Stability studies show no significant changes. Conclusion: Results indicate that gastric-floating formulations of nizatidine have the prospective for superior gastric residence time and sustained drug release.

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