In Situ Gel Polymers: A Review

Konatham, Mounika; Gorle, Mounika Tejaswi; Naveen, P; Bakshi, Vasudha; Mamidisetti, Yaso Deepika; Chinthakindi, Priyanka; Jadi, Rajendra Kumar

doi:10.22159/ijap.2021v13i1.39504

Cited by 8 publications

(5 citation statements)

References 73 publications

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“…Gellan gum membentuk gel dengan adanya kation logam (mono atau divalen). Kation monovalen seperti Na + atau K + dan kation divalen seperti Ca 2+ atau Mg 2+ akan menginduksi gelasi (Konatham et al, 2021).…”

Section: Tabel 3 Gelling Agent Dan Uji Performa Sediaan Gel In Situunclassified

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Rancangan Pengembangan Sediaan Nanospraygel in situ Mengandung Minyak Kulit Batang Kayu Manis (Cinnamomum burmannii (Nees & T. Nees) Blume) untuk Pengobatan Kandidiasis Oral

Apriliyani

Priani²,

Hidayat

2021

JRF

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Abstract. Cinnamon bark oil is known to have antifungal activity so it can be used for oral candidiasis treatment. Thick and impenetrable oral mucosa needs to be treated with modification. Development of in situ nanospraygel can increase the effectiveness and reduce the risk of contamination of the preparation. This study tries to investigate the antifungal activity of cinnamon bark oil, determine suitable formula for the cinnamon bark oil nanoemulsion, and determine the type of gelling agent that can be used to develop in situ nanospraygel. The design of in situ nanospraygel formula containing cinnamon bark oil was carried out by Systematic Literature Review. The study was conducted on articles from reputable databases that matched the inclusion and exclusion criteria. The results of study showed that cinnamon bark oil of Cinnamomum burmannii has antifungal activity against Candida albicans with a minimum inhibitory concentration of 0.039%. Cinnamon bark oil 1% can be formulated into a good nanoemulsion preparation, using Tween 80 as a surfactant with a ratio of oil and surfactant 1:3.The combination of carbopol 934P & gellan gum with a concentration of 0.2% each can be used as an in situ gelling agent to produce cinnamon bark oil Nanospraygel in situ. Abstrak. Minyak kulit batang kayu manis memiliki aktivitas anti jamur sehingga dapat digunakan untuk pengobatan kandidiasis oral. Mukosa mulut yang tebal dan sulit ditembus perlu diatasi dengan modifikasi sediaan. Maka dari itu dilakukan pengembangan sediaan nanospraygel in situ untuk meningkatkan efektivitas dan mengurangi resiko kontaminasi sediaan. Penelitian ini bertujuan untuk mengkaji aktivitas antijamur minyak kulit batang kayu manis, mengetahui formulasi yang sesuai untuk nanoemulsi minyak kulit batang kayu manis, serta mengetahui jenis gelling agent yang dapat digunakan untuk mengembangkan nanospraygel in situ. Perancangan formula nanospraygel in situ minyak kulit batang kayu manis dilakukan dengan kajian berbasis Systematic Literature Review. Kajian dilakukan terhadap artikel dari databased bereputasi yang memenuhi kriteria inklusi dan eksklusi. Hasil kajian menunjukkan minyak kulit batang kayu manis spesies Cinnamomum burmannii memiliki aktivitas anti jamur terhadap Candida albicans dengan konsentrasi hambat minimum yaitu 0,039%. Minyak kulit batang kayu manis 1% dapat diformulasi menjadi sediaan nanoemulsi yang baik, menggunakan Tween 80 sebagai surfaktan dengan perbandingan minyak dan surfaktan 1:3. Untuk menghasilkan sediaan nanospraygel in situ minyak kulit batang kayu manis dapat digunakan kombinasi carbopol 934P & gellan gum dengan konsentrasi masing-masing yaitu 0,2% sebagai gelling agent in situ

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Section: Tabel 3 Gelling Agent Dan Uji Performa Sediaan Gel In Situunclassified

“…Sodium alginat adalah polisakarida kopolimer blok linier terdiri dari asam β-Dmannuronat dan residu asam α-L-glukuronat yang digabungkan dengan ikatan 1,4-glikosidik (Konatham et al, 2021). Sodium alginat merupakan jenis polimer in situ gel yang sensitif terhadap ion.…”

Section: Tabel 3 Gelling Agent Dan Uji Performa Sediaan Gel In Situunclassified

Rancangan Pengembangan Sediaan Nanospraygel in situ Mengandung Minyak Kulit Batang Kayu Manis (Cinnamomum burmannii (Nees & T. Nees) Blume) untuk Pengobatan Kandidiasis Oral

Apriliyani

Priani²,

Hidayat

2021

JRF

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“…Second-generation antihistamines treat allergic rhinitis, urticaria, discomfort, small cuts, insect bites, burns, rashes, and atopic dermatitis [16][17][18]. Gels are dosage form that trap large volumes of aqueous or hydroalcoholic liquid in a network of inorganic or organic polymer colloidal solid particles [19]. Compared to ointments and cream bases, they have a higher aqueous component that allows drugs to dissolve and migrate through a liquid carrier [20].…”

Section: Introductionmentioning

confidence: 99%

Formulation, development, and characterization of loratadine emulgel

Sharaff,

Renukuntla,

Peddapalli

et al. 2024

JAPR

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Background: This study was to develop loratadine (LTD) emulgels to treat localized skin allergy. Method: Initially oil-in-water emulsion was prepared by 3 different types of surfactants & finally gelling agent carbopol 940 was incorporated into emulsion to produce emulgel (i.e., standard conventional method). Results: The developed formulations were characterized using various parameters including particle size (PS), zeta potential (ZP), polydispersity index (PDI), entrapment efficacy (EE), pH, extrusion efficacy, physical stability, in-vitro drug release studies, and scanning electron microscopy (SEM). PS, EE, PDI, ZP and In-vitro studies ranges between 186.25 ± 6.42 mm (LE-F4) to 395.24 ± 8.64 mm (LE-F1), 62.38 ± 0.36 % (LE-F2) to 76.48 ± 0.69 % (LE-F4), 0.276 ± 0.02 (LE-F4) to 0.652 ± 0.02 (LE-F1), 16.45 ± 2.13 mV (LE-F1) to 29.46 ± 2.78 mV (LE-F3) and 21.90 ± 0.3 % (LE-F1) to 68.30±0.9 % (LE-F4) respectively. Conclusion: Based on all physicochemical properties, LE-F4 formulation was considered to be optimized with minimum PS (186.25±6.42 nm), PDI (0.276±0.02), satisfactory positive surface charge (23.15 ± 1.89 mV) and maximum EE (76.48±0.69 %). FTIR studies were confirmed that there is no physical interaction between drug and excipients and SEM studies revealed that vesicle size was spherical with smooth texture. A significantly greater rate of drug release (i.e., 68.30 ± 0.90%) was seen in the LTD emulgels that were made with cationic surfactant (i.e., LE-F4) and found to be good spreadability and extrudability.

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“…Examples of natural polymers includes chitosan, guargum, tragacanth, pectin, carageenan, xanthan gum while examples of synthetic or semi-synthetic polymers includes methyl cellulose, poloxamer, PLGA, HPMC, carbopol, Pluronics. 8 The in situ gels were subjected to evaluation parameters like physical appearance, gelling capacity, determination of pH, rheological measurement, drug content and sterility testing.…”

Section: Introductionmentioning

confidence: 99%

Fabrication, Characterization, and in vitro Evaluation of Atenolol Loaded Microsponges for Ocular Delivery

Dhyani,

Kumar

2024

Ind. J. Pharm. Edu. Res

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Aim:The purpose of the study was development and evaluation of Atenolol loaded microsponge in situ gel for the management of ocular hypertension, glaucoma. Materials and Methods: The microsponges were prepared by modified oil in oil emulsion solvent diffusion method. The polymers used for fabrication of microsponges include Ethyl Cellulose and Eudtagit RL-100. Results: The results of particle reveals that the particle size varies from 7.33 to 9.76μm, percentage yield ranges from 59.98 to 81.22, entrapment efficiency (%) 58.23 to 80.56 and drug content (%) varies from 54.12 to 82.89. Further, the microsponges were loaded in in situ gel. The in situ gel was fabricated by using Poloxamer 407 and HPMC K4M polymers. The microsponges loaded in situ gel was evaluated for different parameters like pH, viscosity, gelling capacity, gelation temperature and drug release study. The pH varies from 6.83 to 7.43, viscosity ranges from 7421 to 15623 cp, gelation temperature ranges from 37.14 to38.22°C while the drug release ranges from 62.52 to 83.32%. At last, the stability study report indicated that the developed drug loaded microsponge in situ gel were physically and chemically stable over a period of three months. Sterility testing was conducted in the optimized formulations as per Indian Pharmacopoeia. The studies reveal that there was no sign of growth of microorganism. Conclusion: Atenolol loaded microsponge loaded in situ gel can effectively treat Glaucoma and improve the patient compliance.

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In Situ Gel Polymers: A Review

Cited by 8 publications

References 73 publications

Rancangan Pengembangan Sediaan Nanospraygel in situ Mengandung Minyak Kulit Batang Kayu Manis (Cinnamomum burmannii (Nees & T. Nees) Blume) untuk Pengobatan Kandidiasis Oral

Rancangan Pengembangan Sediaan Nanospraygel in situ Mengandung Minyak Kulit Batang Kayu Manis (Cinnamomum burmannii (Nees & T. Nees) Blume) untuk Pengobatan Kandidiasis Oral

Formulation, development, and characterization of loratadine emulgel

Fabrication, Characterization, and in vitro Evaluation of Atenolol Loaded Microsponges for Ocular Delivery

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