In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof

Jeong, Byeongmoon; Bae, You Han; Kim, Sung Wan

doi:10.1002/(sici)1097-4636(200005)50:2<171::aid-jbm11>3.0.co;2-f

Cited by 259 publications

(70 citation statements)

References 21 publications

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“…The combination of hydrophobic/hydrophilic units created a surfactant behavior of the polymers in water, facilitating thus also the solubilization of hydrophobic drugs. In vivo studies showed sufficient mechanical properties and integrity for longer than a month [71]. More recently, Chen et al [72] developed a triblock PLGA-PEG-PLGA-based system for the controlled release of testosterone.…”

Section: Peg/biodegradable Polyester Copolymersmentioning

confidence: 99%

Thermoresponsive hydrogels in biomedical applications

Klouda

Mikos

2008

European Journal of Pharmaceutics and Biopharmaceutics

1,135

696

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Environmentally responsive hydrogels have the ability to turn from solution to gel when a specific stimulus is applied. Thermoresponsive hydrogels utilize temperature change as the trigger that determines their gelling behavior without any additional external factor. These hydrogels have been interesting for biomedical uses as they can swell in situ under physiological conditions and provide the advantage of convenient administration. The scope of this paper is to review the aqueous polymer solutions that exhibit transition to gel upon temperature change. Typically, aqueous solutions of hydrogels used in biomedical applications are liquid at ambient temperature and gel at physiological temperature. The review focuses mainly on hydrogels based on natural polymers, N-isopropylacrylamide polymers, poly(ethylene oxide)-b-poly(propylene oxide)-bpoly(ethylene oxide) polymers as well as poly(ethylene glycol)-biodegradable polyester copolymers.

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Section: Peg/biodegradable Polyester Copolymersmentioning

confidence: 99%

Thermoresponsive hydrogels in biomedical applications

Klouda

Mikos

2008

European Journal of Pharmaceutics and Biopharmaceutics

1,135

696

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“…A transparent gel was formed in situ after injection of a 33 wt.-% PEG-PLGA-PEG (550-2810-550) aqueous solution into rats, and gel integrity persisted for one month. [21] Interestingly, thermosensitive hydrogels based on PLGA-PEG-PLGA (BAB-type) (Scheme 3) showed a sol-to-gel transition similar to that of PEG-PLGA-PEG (ABA-type) copolymer hydrogels. [22][23][24] However, the synthetic procedure for BAB-type hydrogels was simpler than that for the ABA-type, using HMDI as a coupling agent.…”

Section: Poly(ethylene Glycol) (Peg)/polyestermentioning

confidence: 99%

Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

424

343

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Injectable biodegradable copolymer hydrogels, which exhibit a sol–gel phase transition in response to external stimuli, such as temperature changes or both pH and temperature (pH/temperature) alterations, have found a number of uses in biomedical and pharmaceutical applications, such as drug delivery, cell growth, and tissue engineering. These hydrogels can be used in simple pharmaceutical formulations that can be prepared by mixing the hydrogel with drugs, proteins, or cells. Such formulations are administered in a straightforward manner, through site‐specific control of release behavior, and the hydrogels are compatible with biological systems. This review will provide a summary of recent progress in biodegradable temperature‐sensitive polymers including polyesters, polyphosphazenes, polypeptides, and chitosan, and pH/temperature‐sensitive polymers such as sulfamethazine‐, poly(β‐amino ester)‐, poly(amino urethane)‐, and poly(amidoamine)‐based polymers. The advantages of pH/temperature‐sensitive polymers over simple temperature‐sensitive polymers are also discussed. A perspective on the future of injectable biodegradable hydrogels is offered.magnified image

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“…Recently, novel biodegradable triblock copolymers of polyethylene glycol and poly(lactic/glycolic acid or PEG-PLGA-PEG) were developed by Jeong et al (1997Jeong et al ( , 1999Jeong et al ( , 2000a. Aqueous solutions of these copolymers exhibit sol-to-gel transition at body temperature.…”

Section: Thermoreversible Gelsmentioning

confidence: 99%

Injectable gels for tissue engineering

2001

Self Cite

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Recently, tissue engineering approaches using injectable, in situ gel forming systems have been reported. In this review, the gelation processes and several injectable systems that exhibit in situ gel formation at physiological conditions are discussed. Applications of selected injectable systems (alginate, chitosan, hyaluronan, polyethylene oxide/polypropylene oxide) in tissue engineering are also described. Injectable polymer formulation can gel in vivo in response to temperature change (thermal gelation), pH change, ionic cross-linking, or solvent exchange. Kinetics of gelation is directly affected by its mechanism. Injectable formulations offer specific advantages over preformed scaffolds such as: possibility of a minimally invasive implantation, an ability to fill a desired shape, and easy incorporation of various therapeutic agents. Several factors need to be considered before an injectable gel can be selected as a candidate for tissue engineering applications. Apart from tissue-specific cell-matrix interactions, the following gel properties need to be considered: gelation kinetics, matrix resorption rate, possible toxicity of degradation products and their elimination routes, and finally possible interference of the gel matrix with histogenesis. Anat

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In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof

Cited by 259 publications

References 21 publications

Thermoresponsive hydrogels in biomedical applications

Thermoresponsive hydrogels in biomedical applications

Injectable Biodegradable Hydrogels

Injectable gels for tissue engineering

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