In situ gelling aqueous solutions of pH- and temperature-sensitive poly(ester amino urethane)s

Kasala, Dayananda; He, Chaoliang; Lee, Sang Soo

doi:10.1016/j.polymer.2008.08.010

Cited by 48 publications

(42 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequently, a series of pH/temperature-sensitive multiblock copolymers based on poly(amino urethane) (PAU) were reported. [86] The multiblock copolymers were synthesized by polyaddition of HO-PCL-PEG-PCL-OH, bis-1,4-(hydroxyethyl)piperazine (HEP), and 1,6-diisocynato hexamethylene (HDI) (PCL-PEG-PCL-PAU) n (Scheme 11).…”

Section: Scheme 10 Structure Of Pae-pcl-peg-pcl-paementioning

confidence: 99%

“…PLGA Chondrocyte MPEG-PCL rBMSC, dexamethasone [104] FITC-BSA, BSA [105,106] Cholesterol end-capped star PEG-PLLA L929 cells [46] PEG/PPG/PHB BSA [48] Polyphosphazenes FITC-dextran, HSA [107] Doxorubicin, paclitaxel [108,112] FITC-albumin [109] Pancreatic islets, hepatocytes [110,111] C/GP Camptothecin, insulin [113,114] Bovine chondrocytes [115] pH/temperature-sensitive OSM-PCLA-PEG-PCLA-OSM Paclitaxel [116] hMSCs [117] PAE-PCL-PEG-PCL-PAE Insulin [82,118] (PCL-PEG-PCL-PAU) n Paclitaxel [86] (PEG-PAU) m Chlorambucil [87] PAA-PEG-PAA Flurbiprofen [90] PAE-PEG-PAE Lidocaine [89] matrices or cell growth depots. Table 1 summarizes the biomedical applications of the biodegradable injectable hydrogels.…”

Section: Hydrogel Types Polymer Delivery/applications Referencesmentioning

confidence: 99%

“…For these polymers, drug encapsulation was easily performed at pH 5.0-6.0 and 2 8C because of their solubility character. [86,87] PAE-PEG-PAE and PAA-PEG-PAA hydrogels may have potential for drug delivery at mucosal surfaces. [89,90] Lidocaine and flurbiprofen were released from PAE-PEG-PAE and PAA-PEG-PAA hydrogels over the course of one day, indicating that these hydrogels could be used as drug carriers.…”

Section: Ph/temperature-sensitive Block Copolymer Hydrogelsmentioning

confidence: 99%

See 2 more Smart Citations

Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

Self Cite

422

343

View full text Add to dashboard Cite

Injectable biodegradable copolymer hydrogels, which exhibit a sol–gel phase transition in response to external stimuli, such as temperature changes or both pH and temperature (pH/temperature) alterations, have found a number of uses in biomedical and pharmaceutical applications, such as drug delivery, cell growth, and tissue engineering. These hydrogels can be used in simple pharmaceutical formulations that can be prepared by mixing the hydrogel with drugs, proteins, or cells. Such formulations are administered in a straightforward manner, through site‐specific control of release behavior, and the hydrogels are compatible with biological systems. This review will provide a summary of recent progress in biodegradable temperature‐sensitive polymers including polyesters, polyphosphazenes, polypeptides, and chitosan, and pH/temperature‐sensitive polymers such as sulfamethazine‐, poly(β‐amino ester)‐, poly(amino urethane)‐, and poly(amidoamine)‐based polymers. The advantages of pH/temperature‐sensitive polymers over simple temperature‐sensitive polymers are also discussed. A perspective on the future of injectable biodegradable hydrogels is offered.magnified image

show abstract

Section: Scheme 10 Structure Of Pae-pcl-peg-pcl-paementioning

confidence: 99%

Section: Hydrogel Types Polymer Delivery/applications Referencesmentioning

confidence: 99%

Section: Ph/temperature-sensitive Block Copolymer Hydrogelsmentioning

confidence: 99%

See 1 more Smart Citation

Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

Self Cite

422

343

View full text Add to dashboard Cite

show abstract

“…After that, the aqueous layer was retrieved, acidified with 10%HCl to a pH 1-2 and then extracted with ethyl acetate, while the combined organic layers was stirred in the presence of MgSO 4 as a drying agent. As soon as MgSO 4 were filtered out of these layers by paper filters (0.2 mm), the organic solution was evaporated under vacuum to give Benzenesulfonyl-D,L-Serine (mSerine) as a bright yellow compound.…”

Section: Modification Of Dl-serine With Benzenesulfonyl Chloridementioning

confidence: 99%

pH/TEMPERATURE SENSITIVE PENTABLOCK BASED ON D,L-SERINE

Huynh

2018

JST

View full text Add to dashboard Cite

For recent decades, researchers have been increasing their attention to pH/temperaturesensitive polymers as drug/protein delivery systems. In this research, we aim to synthesize a new pH/temperature sensitive pentablock based on D,L-Serine. Amino groups of D,L-Serine were modified with benzenesulfonyl chloride in order to create sulfonamide groups as desired pHsensitive groups. Pentablocks were then synthesized by conjugation reaction between carboxylic, hydroxyl groups of D,L-Serine and hydroxyl-terminal groups of temperature sensitive triblock PCL-PEG-PCL. The synthesized products were analyzed by 1H-NMR and their molecular weights were measured by gel permeation chromatography (GPC). The sol-gel transition of pentablock was also investigated by the inverting test method. The pH dependent property of the pH sensitive moiety could be very useful for preparing drug carriers.

show abstract

“…[1][2][3][4][5][6] pH and temperature sensitive hydrogels containing cationic groups that can bind macromolecules through ionic interactions have received a great deal of interest for use as drug delivery systems. 4,7,9 Recently, poly(β-amino ester) (PAE) and poly(amino urethane) (PAU) were conjugated to poly(caprolactone)-poly(ethylene glycol)-poly(caprolactone) (PCL-PEG-PCL) to create a pentablock copolymer 4 and a multiblock copolymer, 7 respectively. These copolymers undergo sol-gel transitions in water (20 wt%) as a function of the pH and temperature under near physiological conditions (pH 7.4, 37 o C).…”

Section: Introductionmentioning

confidence: 99%

Bioadhesive PAA-PEG-PAA triblock copolymer hydrogels for drug delivery in oral cavity

Nguyen

Lee

2010

Macromol. Res.

Self Cite

View full text Add to dashboard Cite

A series of poly(amidoamine)-poly(ethylene glycol)-poly(amidoamine) (PAA-PEG-PAA) triblock copolymers were designed and prepared to examine the factors affecting their sol-gel transition behavior. The physiochemical properties of the triblock copolymers were characterized by 1 H NMR spectroscopy and gel permeation chromatography. The PAA-PEG-PAA copolymers underwent sol-gel transitions in solution (10-15 wt%) in response to changes in both the pH and temperature. The sol-gel transition phase behavior was controlled by adjusting the molecular weights of the PEG and PAA blocks and changing the PAA-PEG-PAA concentration. These copolymers demonstrated stronger bioadhesive properties than chitosan and poly(acrylic acid) in an aqueous solution. The in vitro release of flubiprofen was controllable using these copolymer hydrogels.

show abstract

In situ gelling aqueous solutions of pH- and temperature-sensitive poly(ester amino urethane)s

Cited by 48 publications

References 45 publications

Injectable Biodegradable Hydrogels

Injectable Biodegradable Hydrogels

pH/TEMPERATURE SENSITIVE PENTABLOCK BASED ON D,L-SERINE

Bioadhesive PAA-PEG-PAA triblock copolymer hydrogels for drug delivery in oral cavity

Contact Info

Product

Resources

About