In situ gelling drug delivery systems for topical drug delivery

Kolawole, Oluwadamilola M.; Cook, Michael T.

doi:10.1016/j.ejpb.2023.01.007

Cited by 59 publications

(29 citation statements)

References 64 publications

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“…As the external pH increases, the polymers become deprotonated, which leads to excess polymer-polymer repulsion, hence the physical transformation. [8] In contrast, polymers with weak basic moieties become viscous gel as the external pH decreases. This can be attributed to the increase in favorable polymer-polymer interactions, namely hydrogen bonding among carboxyl groups, that lead to the formation of a gel.…”

Section: Preparation Of Hydrogelsmentioning

confidence: 99%

“…This can be attributed to the increase in favorable polymer-polymer interactions, namely hydrogen bonding among carboxyl groups, that lead to the formation of a gel. [8] Currently, pH-sensitive polymers that are prevalently used in ocular formulations include carbomer and chitosan. [3] Temperature-sensitive hydrogels Thermosensitive hydrogels retain a liquid state at ambient temperatures of around 25°C, otherwise known as the hydrogel's lower critical solution temperature (LCST).…”

Section: Preparation Of Hydrogelsmentioning

confidence: 99%

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Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Kulbay,

Wu,

Truong

et al. 2024

Smart Molecules

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This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning with the foundational definition, properties, and classification of hydrogels, the review explores their synthesis and responsive capabilities. Specific applications examined encompass topical drug delivery, contact lenses, intravitreal drug delivery, ocular adhesives, vitreous substitutes, and cell‐based therapy. A methodical analysis, including an overview of relevant ocular structures and a comparative evaluation of hydrogel‐based solutions against traditional treatments, is conducted. Additionally, potential constraints, translation challenges, knowledge gaps, and research areas are identified. Our methodical approach, guided by an extensive literature review from 2017 to 2023, illuminates the unprecedented opportunities offered by hydrogels, along with pinpointing areas for further inquiry to facilitate their transition into clinical practice.

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Section: Preparation Of Hydrogelsmentioning

confidence: 99%

Section: Preparation Of Hydrogelsmentioning

confidence: 99%

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Kulbay,

Wu,

Truong

et al. 2024

Smart Molecules

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“…[ [354][355][356] in the early stages of therapy (Figure 23Biii). Furthermore, TGNPs improve tear production and reduce eye inflammation, indicating their safety and efficacy for treating dry eye disease (DED).…”

Section: Ggmentioning

confidence: 99%

The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

Prasathkumar

Chenthamara

Lin

et al. 2023

Adv Materials Technologies

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Corneal blindness is explained by a large reduction in vision loss caused by acute and chronic corneal diseases and/or disorders. Due to the severe unavailability of donor corneas, immune rejection, and the side effects of keratoprosthesis (KPro), vision‐impaired patients are often unable to restore their vision. Corneal tissue engineering appears to be a promising method using natural polymers made from different layers of corneal cells such as epithelium, stroma, and endothelium or full tissue equivalents. Proteins and polysaccharides are able to mimic the chemical composition of the native extracellular matrix (ECM), which has been extensively studied for corneal tissue engineering. Additionally, protein‐based materials are highly favored in corneal regenerative therapy as they have the proper cell‐binding sites for cell adhesion, corneal innervation regeneration, and oxidative stress suppression, while polysaccharide‐based materials can also promote cell proliferation and adhesion as well as ocular permeability. Herein, a comprehensive review of various biomaterials based on natural proteins (fibrin, fibrinogen, silk fibroin, collagen, gelatin, and serum albumin) and polysaccharides (chitin, chitosan, hyaluronic acid, alginate, cellulose, and gellan gum) for corneal tissue engineering are provided. The protein‐polysaccharide biomaterials are mainly used in the form of hydrogels, films, scaffolds, sutures, eye drops, nanocarriers, and nanocapsules to treat ocular diseases that cause blindness, such as corneal wounds, corneal ulcers, Goldenhar syndrome, corneal endothelium and stroma defects, corneal neovascularization, etc. In this review, insight is provided into recent developments in the areas of biomaterial design, cross‐linking strategy, corneal cell selection, and frontiers that are expected to offer researchers support and creativity in the development of corneal regenerative medicine.

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“…Currently, local drug delivery systems demonstrate benefits in terms of tumor drug accumulation and regulated drug release. , Among them, localized drug delivery platforms have the capability to establish drug reservoirs at the tumor area, enabling sustained and controlled release of loaded drugs over an extended duration. As a result, these systems effectively impede tumor growth. , In situ hydrogels, especially temperature-sensitive hydrogels, have good fluidity and can be directly injected into or around tumors. − The transformation from liquid to gel under the action of body temperature can well cover the tumor tissue on the one hand and prolong the local residence time of the drug on the other hand, forming a high-concentration drug reservoir. , Therefore, local drug delivery systems combining injectable hydrogels with nanomedicines are expected to produce synergistic effects, which are of great significance for tumor therapy. ,, …”

Section: Introductionmentioning

confidence: 99%

“…25−27 The transformation from liquid to gel under the action of body temperature can well cover the tumor tissue on the one hand and prolong the local residence time of the drug on the other hand, forming a high-concentration drug reservoir. 28,29 Therefore, local drug delivery systems combining injectable hydrogels with nanomedicines are expected to produce synergistic effects, which are of great significance for tumor therapy. 24,30,31 The selection of suitable materials as the host of hydrogels is crucial for regulating the physicochemical properties and biological effects of hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Thermo-Sensitive Nanoparticle-Hydrogel Composite Based on Pluronic F127 and Phycocyanin for an Enhanced Chemo-Photodynamic Antitumor Effect

Song

Zhang

et al. 2023

ACS Appl. Polym. Mater.

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The concurrent utilization of chemotherapy and photodynamic therapy (PDT) can successfully slow the growth of tumors while minimizing systemic toxicity. An injectable temperature-sensitive hydrogel was constructed based on Pluronic F127 and phycocyanin (PC). Nanoparticles formed by self-assembly of doxorubicin and ursolic acid (DOX–UA NPS) were further loaded into the hydrogel to give a local drug delivery platform (DOX–UA NPs@Gel). DOX–UA NPs@Gel can be enriched in situ in tumors and continuously release DOX–UA NPs and free PC. UA can promote the responsiveness of tumor cells to DOX. As a natural photosensitizer, PC can produce reactive oxygen species (ROS) when exposed to laser radiation and has significant PDT activity. The MTT assay demonstrated that DOX–UA NPs@Gel under irradiation caused the highest cytotoxicity at 91.6%. The anti-tumor efficiency of various nanoparticles and nanoparticle-loaded hydrogels (the injection dose of DOX is 6 mg/kg) was verified in the H22 tumor-bearing mice (male ICR). In vivo antitumor results demonstrated that DOX–UA NPs@Gel with the combination of chemotherapy and PDT exhibited unique anticancer efficacy with low toxicity. When exposed to radiation after the experiment, the DOX–UA NPs@Gel showed a tumor volume of merely 319 mm3, displaying an exceptional tumor growth inhibition rate of 91.05%. Therefore, the local drug delivery system based on the thermosensitive hydrogel can effectively achieve synergistic antitumor effects.

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In situ gelling drug delivery systems for topical drug delivery

Cited by 59 publications

References 64 publications

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

Thermo-Sensitive Nanoparticle-Hydrogel Composite Based on Pluronic F127 and Phycocyanin for an Enhanced Chemo-Photodynamic Antitumor Effect

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