In situ-gelling starch nanoparticle (SNP)/O-carboxymethyl chitosan (CMCh) nanoparticle network hydrogels for the intranasal delivery of an antipsychotic peptide

Majcher, Michael J.; Ali, Babar; Lofts, Andrew; Leung, Ashlyn; Li, Xiaoyun; Abu-Hijleh, Fahed; Smeets, Niels M. B.; Mishra, Ram K.; Hoare, Todd

doi:10.1016/j.jconrel.2020.12.050

Cited by 52 publications

(31 citation statements)

References 58 publications

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“…Among all the systems reviewed above, the SNP‐CMCh is more convenient and effective in releasing PAOPA in the brain because of the low antipsychotic therapeutic dosage (0.5 mg kg −1 ) and its relatively rapid (within 72 h) pharmacokinetic effect on alleviation of the symptoms when administrated via IN. [ 116 ]…”

Section: Types Of Nps Developed For the In Delivery To The Brainmentioning

confidence: 99%

Intranasal Delivery of Functionalized Polymeric Nanomaterials to the Brain

Zha

Wong

All

2022

Adv Healthcare Materials

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Intravenous delivery of nanomaterials containing therapeutic agents and various cargos for treating neurological disorders is often constrained by low delivery efficacy due to difficulties in passing the blood-brain barrier (BBB). Nanoparticles (NPs) administered intranasally can move along olfactory and trigeminal nerves so that they do not need to pass through the BBB, allowing non-invasive, direct access to selective neural pathways within the brain. Hence, intranasal (IN) administration of NPs can effectively deliver drugs and genes into targeted regions of the brain, holding potential for efficacious disease treatment in the central nervous system (CNS). In this review, current methods for delivering conjugated NPs to the brain are primarily discussed. Distinctive potential mechanisms of therapeutic nanocomposites delivered via IN pathways to the brain are then discussed. Recent progress in developing functional NPs for applications in multimodal bioimaging, drug delivery, diagnostics, and therapeutics is also reviewed. This review is then concluded by discussing existing challenges, new directions, and future perspectives in IN delivery of nanomaterials.

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Section: Types Of Nps Developed For the In Delivery To The Brainmentioning

confidence: 99%

Intranasal Delivery of Functionalized Polymeric Nanomaterials to the Brain

Zha

Wong

All

2022

Adv Healthcare Materials

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“…This strategy presents the potential to significantly reduce the dose frequency and side effects of antipsychotics through a minimally invasive route of administration. This strategy offers alleviation of schizophrenic negative symptoms up to 72 h in the schizophrenia rat model at lower doses than intraperitoneal administration of the drug (twice) to achieve therapeutic response for only a few hours ( Majcher et al, 2021 ). Another similar study emphasized the development of clozapine-loaded nanoemulsion based on an in situ gel for bioavailability enhancement via intranasal administration.…”

Section: Recent Advancement Of Delivering Antipsychotics Using Intran...mentioning

confidence: 99%

Advances and Challenges in Intranasal Delivery of Antipsychotic Agents Targeting the Central Nervous System

et al. 2022

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Treatment of central nervous system (CNS) disorders is challenging using conventional delivery strategies and routes of administration because of the presence of the blood–brain barrier (BBB). This BBB restricts the permeation of most of the therapeutics targeting the brain because of its impervious characteristics. Thus, the challenges of delivering the therapeutic agents across the BBB to the brain overcoming the issue of insufficient entry of neurotherapeutics require immediate attention for recovering from the issues by the use of modern platforms of drug delivery and novel routes of administration. Therefore, the advancement of drug delivery tools and delivering these tools using the intranasal route of drug administration have shown the potential of circumventing the BBB, thereby delivering the therapeutics to the brain at a significant concentration with minimal exposure to systemic circulation. These novel strategies could lead to improved efficacy of antipsychotic agents using several advanced drug delivery tools while delivered via the intranasal route. This review emphasized the present challenges of delivering the neurotherapeutics to the brain using conventional routes of administration and overcoming the issues by exploring the intranasal route of drug administration to deliver the therapeutics circumventing the biological barrier of the brain. An overview of different problems with corresponding solutions in administering therapeutics via the intranasal route with special emphasis on advanced drug delivery systems targeting to deliver CNS therapeutics has been focused. Furthermore, preclinical and clinical advancements on the delivery of antipsychotics using this intranasal route have also been emphasized.

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“…The in situ gelling bulk CMCh/SNP enables good retention and mucoadhesion upon spraying into the nose; however, as the material degrades via hydrolysis, the ultra-small SNPs (20-50 nm in diameter) are released and can transport through the nasal epithelium and ultimately to the brain via the trigeminal and olfactory nerves, facilitating local delivery of antipsychotic drugs over longer time periods following a single intranasal spray (3-5 days) with fewer systemic side effects (Figure 12). [94] Figure 12. An internasal plum pudding NNH spray based on carboxymethyl chitosan and oxidized starch nanoparticles (SNPs) (<20 nm) crosslinked via Schiff bases.…”

Section: Promoting Long-term Biological Penetration and Size Switchingmentioning

confidence: 99%

“…For example, intra-NP crosslinks may be stable in the presence of pH changes that can break NPpolymer crosslinks, [17,60] resulting in the triggered release of nanoparticles over time from the NNH. [94]…”

Section: Stimuli Responsivitymentioning

confidence: 99%

A Review of Design and Fabrication Methods for Nanoparticle Network Hydrogels for Biomedical, Environmental, and Industrial Applications

Campea

Majcher

Lofts

et al. 2021

Adv Funct Materials

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Nanoparticle network hydrogels (NNHs) in which nanoparticles are used as a key building block to build the gel network have attracted significant interest given their potential to leverage the favorable properties of both hydrogels (e.g., hydrophilicity, tunable pore sizes, mechanics, etc.) and a variety of different nanoparticles (e.g., high surface area, chemical activity, independently tunable porosity, mechanics) to create new functional materials. Herein, recent progress in the design and use of NNHs is comprehensively reviewed, with an emphasis on defining the typical gel morphologies/architectures that can be achieved with NNHs, the typical crosslinking approaches used to fabricate NNHs, the fundamental properties and functional benefits of NNHs, and the reported applications of NNHs in electronics (flexible electronics, sensors), environmental (sorbents, separations), agriculture, self‐cleaning‐materials, and biomedical (drug delivery, tissue engineering) applications. In particular, the way in which the NNH structure is applied to improve the performance of the hydrogel in each application is emphasized, with the aim to develop a set of principles that can be used to rationally design NNHs for future uses.

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In situ-gelling starch nanoparticle (SNP)/O-carboxymethyl chitosan (CMCh) nanoparticle network hydrogels for the intranasal delivery of an antipsychotic peptide

Cited by 52 publications

References 58 publications

Intranasal Delivery of Functionalized Polymeric Nanomaterials to the Brain

Intranasal Delivery of Functionalized Polymeric Nanomaterials to the Brain

Advances and Challenges in Intranasal Delivery of Antipsychotic Agents Targeting the Central Nervous System

A Review of Design and Fabrication Methods for Nanoparticle Network Hydrogels for Biomedical, Environmental, and Industrial Applications

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