In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug-controlled release matrices

Zhang, Jihong; Wang, Q.; Wang, A.

doi:10.1016/j.actbio.2009.07.001

Cited by 205 publications

(109 citation statements)

References 33 publications

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“…All of the hydrogels presented a storage modulus (G′) independent of frequency, indicative of the covalent nature; meanwhile G′ values were much higher than the loss modulus (G″) values, suggesting that elasticity dominated these hydrogels [26,27]. This typical elasticity of soft hydrogels mimicking the elastic extracellular matrix is advantageous to cell attachment and proliferation [24]. Among all of these hydrogels, HA bulk gel possessed the highest G′ value of about 800 Pa, as opposed to the slightly decreasing G′ value by raising the HPGMA content.…”

Section: Water Swelling Ratiomentioning

confidence: 99%

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Photo-crosslinking hyaluronan-heparin hybrid hydrogels for BMP-2 sustained delivery

Wang

et al. 2016

Journal of Polymer Engineering

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Abstract A series of hyaluronan-heparin (HA-HP) hybrid hydrogels with an HP mass content from 1% to 10% were constructed by photo-crosslinking for the sustained delivery of growth factors (GFs) in soft tissue engineering. Glycidyl methacrylated HA (HAGMA) and glycidyl methacrylated HP (HPGMA) at a substitution degree of 33% and 17%, respectively, by 1H nucleic magnetic resonance (1H NMR) were synthesized and then used for gelation under ultraviolet radiation, followed by various characterizations, including elemental analysis, scanning electron microscopy (SEM), water swelling test, rheological analysis, and bone morphogenetic protein-2 (BMP-2) loading and delivery. The actual contents of HPGMA in HA-HP hydrogels were almost the same as their feeding ratios, indicative of a complete reaction by photo-crosslinking. The incorporation of HP into HA network gently influenced the morphology, water swelling property and rheological properties of hydrogels, but at 10% HP, it doubly increased the BMP-2 loading capacity to 65 ng/mg, alleviated the BMP-2 burst release to 40% within the initial 4 days and prolonged the BMP-2 sustained delivery to over 28 days. These results revealed that the long-term sustained delivery of BMP-2 from HA hydrogel could be achieved by conjugating HP into the crosslinked network with a controllable content.

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Section: Water Swelling Ratiomentioning

confidence: 99%

“…Water swelling ratio, an important parameter of hydrogels in biomedical application governed by the hydrophilicity/ hydrophobicity and crosslinked network, dominates the solute diffusion and mechanical property of hydrogels [23,24]. The water swelling ratios of various HA-HP hydrogels are shown in Figure 4.…”

Section: Water Swelling Ratiomentioning

confidence: 99%

Photo-crosslinking hyaluronan-heparin hybrid hydrogels for BMP-2 sustained delivery

Wang

et al. 2016

Journal of Polymer Engineering

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“…Hydroxypatite Beads [95] Beads of alginate and hydroxypatite are formed via crosslinking of alginate by calcium component of hydroxypatite.…”

Section: +mentioning

confidence: 99%

Alginate graft copolymers and alginate–co-excipient physical mixture in oral drug delivery

Wong

2011

Journal of Pharmacy and Pharmacology

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Objectives Use of alginate graft copolymers in oral drug delivery reduces dosage form manufacture complexity with reference to mixing or coating processes. It is deemed to give constant or approximately steady weight ratio of alginate to covalently attached co-excipient in copolymers, thereby leading to controllable matrix processing and drug release. This review describes various grafting approaches and their outcome on oral drug release behaviour of alginate graft copolymeric matrices. It examines drug release modulation mechanism of alginate graft copolymers against that of co-excipients in non-grafted formulations. Key findings Drug release from alginate matrices can be modulated through using either co-excipients or graft copolymers via changing their swelling, erosion, hydrophobicity/ hydrophilicity, porosity and/or drug adsorption capacity. However, it is not known if the drug delivery performance of formulations prepared using alginate graft copolymers is superior to those incorporating graft-equivalent co-excipient physically in a dosage form without grafting but at the corresponding graft weight, owing to limited studies being available. Conclusions The value of alginate graft copolymers as the potential alternative to alginate-co-excipient physical mixture in oral drug delivery cannot be entirely defined by past and present research. Such an issue is complicated by the lack of green chemistry graft copolymer synthesis approach, high grafting process cost, complications and hazards, and the formed graft copolymers having unknown toxicity. Future research will need to address these matters to achieve a widespread commercialization and industrial application of alginate graft copolymers in oral drug delivery

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“…Some polymers, such as alginate, are used as polymeric matrix in DDS. However, a weak interaction between the polymers and the drugs, burst release of the drugs and the fast degradation of the polymer contribute to the development of alginate-containing composites 10 . Alginate is a linear copolymer of 1,4-1inked β-Dmannuronic acid (M) and α-L-guluronic acid (G).…”

Section: Introductionmentioning

confidence: 99%

Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices

et al. 2014

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Strontium (Sr) is known to positively affect the mechanism of bone remodelling. Consequently, calcium phosphate bioceramics associated with alginate matrices containing strontium could improve bone regeneration due to gradual strontium release. This work aims to incorporate Sr on microspheres of alginate (ALG)/β-tricalcium phosphate (β-TCP) and evaluates the in vitro release of strontium ions into a buffer solution at pH 4.0 and 7.4. In this study, strontium chloride was employed as a cross-linking agent and Sr source. Energy dispersive spectroscopy (EDS) showed that strontium was incorporated mainly at the surface of the microspheres produced. The in vitro experiments revealed that there is a rapid strontium release up to 24 h at pH 7.4 due to Sr location on microspheres' surface. At pH 4.0 both calcium and strontium were released due to the β-TCP dissolution.

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In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug-controlled release matrices

Cited by 205 publications

References 33 publications

Photo-crosslinking hyaluronan-heparin hybrid hydrogels for BMP-2 sustained delivery

Photo-crosslinking hyaluronan-heparin hybrid hydrogels for BMP-2 sustained delivery

Alginate graft copolymers and alginate–co-excipient physical mixture in oral drug delivery

Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices

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