In situ green synthesis of biocompatible ginseng capped gold nanoparticles with remarkable stability

Leonard, Kwati; Ahmmad, Bashir; Okamura, Hiroaki; Kurawaki, Junichi

doi:10.1016/j.colsurfb.2010.09.020

Cited by 95 publications

(64 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…HAuCl 4 alone caused a drop in survival of 20%. At the same concentration (200 μM), AuNPs caused a dramatic drop in cell viability of more than 84% (Figure 5(a)) [40] [42].…”

Section: Effect Of Aunps On Cell Proliferation Of Sudhl-4 Cellsmentioning

confidence: 99%

Green Synthesis and Characterization of Gold Nanoparticles: Study of Its Biological Mechanism in Human SUDHL-4 Cell Line

Parida¹,

Biswal²,

Bindhani³

2014

ABC

View full text Add to dashboard Cite

In this investigation, the anticancer potentiality and biological mechanism of gold nanoparticles (AuNPs) was studied in SUDHL-4 cell line. Metallic AuNPs were prepared and stabilized with ethanol clove (Syzygium aromaticum) extract. The green synthesis of AuNPs was characterized and evaluated by UV-Visible Spectroscopic, X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Transmission electron microscopy (TEM), Dynamic Light Scattering (DLS) and biological activities using various biochemical assays. Green synthesis of AuNPs was confirmed by instrument method. The TEM images show polydisperse, mostly spherical AuNPs particles of 12 -20 nm. AuNPs were decreased the growth and viability of SU-DHL-4 cell line and increased the apoptosis. The treatments of SU-DHL-4 cells with AuNPs resulted in a moderate considerably increase in Reactive oxygen species (ROS) production. We measured apoptosis by Annexin-V/propidium iodide (PI) in the existence and nonexistence of the antioxidant N-acetyl-Lcysteine (NAC), the glutathione-depleting agent buthionine sulfoximine (BSO), or caspase inhibitors to determine the mechanism of cell death. AuNPs are unique potential anticancer agents that cause ROS-dependent apoptosis in SUDHL-4 cell line which was improved by depletion of glutathione (GHS) and inhibited by N-acetyl-L-cysteine on Z-VAD-FMK.

show abstract

“…HAuCl 4 alone caused a drop in survival of 20%. At the same concentration (200 μM), AuNPs caused a dramatic drop in cell viability of more than 84% (Figure 5(a)) [40] [42].…”

Section: Effect Of Aunps On Cell Proliferation Of Sudhl-4 Cellsmentioning

confidence: 99%

Green Synthesis and Characterization of Gold Nanoparticles: Study of Its Biological Mechanism in Human SUDHL-4 Cell Line

Parida¹,

Biswal²,

Bindhani³

2014

ABC

View full text Add to dashboard Cite

show abstract

“…[9][10][11][12] Recently, synthesis of gold nanoparticles (ANPs) has been the focus of intense scientific research owing to their fascinating chemical, electronic, and optical properties and potential applications in biomedicine, sensing, and catalysis. 13,14 The ANPs are a promising candidate for biomedical engineering and drug delivery applications owing to their unique dimensions, nontoxicity, surface functionalities, and capacity for controlled drug release. 15 Moreover, these nanoparticles can effectively overcome all the physiological barriers and transport the drug to specific target areas such as intracellular compartments or specific cells via passive or ligand-mediated targeting approaches.…”

Section: Introductionmentioning

confidence: 99%

Novel green synthesis of gold nanoparticles using Citrullus lanatus rind and investigation of proteasome inhibitory activity, antibacterial, and antioxidant potential

Patra¹,

Baek²

2015

IJN

View full text Add to dashboard Cite

Biological synthesis of nanoparticles using nontoxic, eco-friendly approaches is gaining importance owing to their fascinating biocompatibility and environmentally benign nature. This study describes the green synthesis approach for synthesis of gold nanoparticles (ANPs) using aqueous extract of the rind of watermelon as a fruit waste and evaluate its biopotential in terms of proteasome inhibitory activity, antibacterial, and antioxidant potential. The synthesized ANPs were characterized using UV–vis spectroscopy, scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, and thermogravimetric analysis. The surface plasmon resonance spectra of ANPs were obtained at 560 nm. Scanning electron microscopy image revealed that particles had a spherical shape and have a size distribution of 20–140 nm, followed by the elemental analysis by energy-dispersive X-ray spectroscopy. X-ray diffraction analysis confirmed the crystallite nature of the ANPs and Fourier-transform infrared spectroscopy revealed the involvement of bioactive compounds from watermelon rind in the synthesis, capping, and stabilization of ANPs. ANPs exhibited potential antibacterial activity against five different foodborne pathogenic bacteria with diameter of inhibition zones ranged between 9.23 and 11.58 mm. They also displayed strong synergistic antibacterial activity together with kanamycin (11.93–21.08 mm inhibition zones) and rifampicin (10.32–24.84 mm inhibition zones). ANPs displayed strong antioxidant activity in terms of DPPH radical scavenging (24.69%), nitric oxide scavenging (25.62%), ABTS scavenging (29.42%), and reducing power. Significantly high proteasome inhibitory potential of the ANPs (28.16%) could be highly useful for cancer treatment and targeted cancer drug delivery. Overall, results highlight a potential low-cost green method of synthesizing ANPs from food waste materials. Significant biopotentials of synthesized ANPs could make it a potential candidate for its application in the biomedical, pharmaceutical, cosmetics, and food sectors.

show abstract

“…(12,39) A peak at 2988 cm −1 was assigned to the stretching vibrations of C-H in methyl and methylene groups. (38,40) 1065 cm −1 was assigned to the bending vibrations of C-C-O or C-C-OH. (38) A shift of frequencies was observed for ginsengAgNPs as compared with ginseng, clearly indicating the potential role of ginseng root powder as a reducing and capping agent for the synthesis of AgNPs.…”

mentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles Using Panax Ginseng Root Extract for the Detection of Hg2+

Tagad¹,

Hyun²,

Rucha³

et al. 2017

Sensors and Materials

View full text Add to dashboard Cite

Exploring biomaterials/molecules as a reducing/capping agent for the synthesis of metal nanoparticles has set a new trend in green nanotechnology with improved environmental safety. Herein, a facile, one-pot, and green synthesis of silver nanoparticles (AgNPs) was achieved using Panax ginseng root extract that was obtained from the root powder as a cost-effective and environmentfriendly biomaterial. Optical, functional, and morphological characteristics of the synthesized AgNPs were determined using ultraviolet-visible (UV-vis), Fourier transform infrared (FTIR) spectrophotometers, transmission electron microscopy (TEM), and atomic force microscopy (AFM). The synthesized AgNPs were used for the detection of Hg 2+ by obtaining the absorption spectrum of the compound as a function of Hg 2+ concentration, which resulted in a decrease in absorption peak intensity with a slight blue shift. The AgNP solution decolored upon dissolution due to the formation of an Ag-Hg amalgam. The sensing characteristics were found to be linear when tested from 10 µM to 1 mM Hg 2+ concentration and the detection limit was estimated as 5 µM. To check the selectivity of the sensor towards Hg 2+ , the sensor response was measured for different heavy metals such as K + , Na + , Cu 2+ , Ni 2+ , Ca 2+ , Zn 2+ , Mg 2+ , and Mn 2+ , at 10 mM concentrations.

show abstract

In situ green synthesis of biocompatible ginseng capped gold nanoparticles with remarkable stability

Cited by 95 publications

References 41 publications

Green Synthesis and Characterization of Gold Nanoparticles: Study of Its Biological Mechanism in Human SUDHL-4 Cell Line

Green Synthesis and Characterization of Gold Nanoparticles: Study of Its Biological Mechanism in Human SUDHL-4 Cell Line

Novel green synthesis of gold nanoparticles using Citrullus lanatus rind and investigation of proteasome inhibitory activity, antibacterial, and antioxidant potential

Green Synthesis of Silver Nanoparticles Using Panax Ginseng Root Extract for the Detection of Hg2+

Contact Info

Product

Resources

About